Faculty of Pharmacy in Hradec Králové
Recent Submissions
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Cannabidiol disrupts tryptophan metabolism in the human term placenta
original article
open access
published version
2024
,Toxicology
,505
(June)
The increasing use of cannabis during pregnancy raises concerns about its impact on fetal development. While cannabidiol (CBD) shows therapeutic promise, its effects during pregnancy remain uncertain. We investigated CBD's ...
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Metformin inhibits OCT3-mediated serotonin transport in the placenta
original article
open access
published version
2024
,Biomedicine & Pharmacotherapy
,179
(October)
Proper fetal development requires tight regulation of serotonin concentrations within the fetoplacental unit. This homeostasis is partly maintained by the placental transporter OCT3/SLC22A3, which takes up serotonin from ...
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Developmental expression of catecholamine system in the human placenta and rat fetoplacental unit
original article
open access
published version
2024
,Scientific Reports
,14
(1)
Catecholamines norepinephrine and dopamine have been implicated in numerous physiological processes within the central nervous system. Emerging evidence has highlighted the importance of tightly regulated monoamine levels ...
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Geldanamycin, a Naturally Occurring Inhibitor of Hsp90 and a Lead Compound for Medicinal Chemistry
summarizing article
open access
published version
2024
,Journal of Medicinal Chemistry
,67
(20)
Geldanamycin remains a driver in the medicinal chemistry of heat shock protein 90 (Hsp90) inhibition, even half a century after its original isolation from nature. This Perspective focuses on the properties of the benzoquinone ...
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Lipid Monolayer on Cell Surface Protein Templates Functional Extracellular Lipid Assembly
original article
open access
published version
2024
,Small
,20
(26)
When the ancestors of men moved from aquatic habitats to the drylands, their evolutionary strategy to restrict water loss is to seal the skin surface with lipids. It is unknown how these rigid ceramide-dominated lipids ...
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Rapid method for screening of both calcium and magnesium chelation with comparison of 21 known metal chelators
original article
open access
published version
2024
,Journal of Biological Inorganic Chemistry
,XXX
(October)
The aim of this study was to develop an affordable, rapid but sensitive and precise method for determining the degree of chelation of calcium and magnesium ions. Spectrophotometric method using o-cresolphthalein complexone ...
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Different behavior of food-related benzoic acids toward iron and copper
original article
open access
published version
2025
,Food Chemistry
,462
(January)
Benzoic acids are commonly found in food and are also produced by human microbiota from other dietary phenolics. The aim was to investigate the interactions of 8 food-related benzoic acids with the physiological metals ...
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Enhancing the Antimycobacterial Efficacy of Pyridine-4-Carbohydrazide: Linkage to Additional Antimicrobial Agents via Oxocarboxylic Acids
original article
open access
accepted version
2024
,RSC Medicinal Chemistry
,15
(říjen)
This study evaluates the antimycobacterial potential of novel "mutual" bioactive amides, combining pyridine-4-carbohydrazide (isoniazid, INH) with various antimicrobial agents (sulphonamides, 4-aminosalicylic acid, ...
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Metabolic dysfunction-associated steatotic liver disease-induced changes in the antioxidant system: a review
summarizing article
open access
published version
2024
,Archives of Toxicology
,Neuveden
(October)
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a heterogeneous condition characterized by liver steatosis, inflammation, consequent fibrosis, and cirrhosis. Chronic impairment of lipid metabolism is ...
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Uncovering Relationships using Bayesian Networks: A Case Study on Conspiracy Theories
article in reviewed proceedings
open access
published version
2024
,Nijmegen
,Proceedings of Machine Learning Research
,Probabilistic Graphical Models
,246
Bayesian networks (BNs) represent a probabilistic model that can visualize relationships between variables. We apply various BN structure learning algorithms to a large dataset from a Czech university entrance exam. This ...
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Hidden potential of hydrazinecarboxamides (semicarbazides) as potential antimicrobial agents: A review
summarizing article
open access
published version
2024
,Biomedicine & Pharmacotherapy
,180
(November)
Hydrazinecarboxamides (semicarbazides) are increasingly recognized as a versatile scaffold in developing potential antimicrobial agents. In addition to a brief overview of the synthetic methods to prepare them, this review ...
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Targeted Protein Degradation (TPD) for Immunotherapy: Understanding Proteolysis Targeting Chimera-Driven Ubiquitin-Proteasome Interactions
summarizing article
open access
published version
2024
,Bioconjugate Chemistry
,35
(8)
Targeted protein degradation or TPD, is rapidly emerging as a treatment that utilizes small molecules to degrade proteins that cause diseases. TPD allows for the selective removal of disease-causing proteins, including ...
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Nanofibers prepared from synthetic polymers and biopolymers as advanced extraction materials for sample preparation prior to liquid chromatography
summarizing article
open access
published version
2024
,Trends in Analytical Chemistry
,180
(November)
Since the beginning of this millennium, there has been an increasing interest in nanofiber-based sorbents for extraction due to their accessibility, scalability, ease of handling, high surface area, variety of chemistries ...
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Advancing Fundamental Understanding of Retention Interactions in Supercritical Fluid Chromatography Using Artificial Neural Networks: Polar Stationary Phases with -OH Moieties
original article
open access
published version
2024
,Analytical Chemistry
,96
(31)
The retention behavior in supercritical fluid chromatography and its stability over time are still unsatisfactorily explained phenomena despite many important contributions in recent years, especially focusing on linear ...
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Metabolomic analysis of the human placenta reveals perturbations in amino acids, purine metabolites, and small organic acids in spontaneous preterm birth
original article
open access
published version
2024
,EXCLI Journal
,23
(February)
Spontaneous preterm delivery presents one of the most complex challenges in obstetrics and is a leading cause of perinatal morbidity and mortality. Although it is a common endpoint for multiple pathological processes, the ...
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Pathological shifts in tryptophan metabolism in human term placenta exposed to LPS or poly I:C
original article
open access
published version
2024
,Biology of Reproduction
,110
(4)
Maternal immune activation during pregnancy is a risk factor for offspring neuropsychiatric disorders. Among the mechanistic pathways by which maternal inflammation can affect fetal brain development and programming, those ...
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N-Pyrazinylhydroxybenzamides as biologically active compounds: a hit-expansion study and antimicrobial evaluation
original article
open access
published version
2023
,Future Medicinal Chemistry
,15
(19)
Background: The development of novel antimicrobial drugs is an essential part of combatting the uprising of antimicrobial resistance. Proper hit-to-lead development is crucially needed. Methods & results: We present a ...
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Novel sulfonamide derivatives as a tool to combat methicillin-resistant Staphylococcus aureus
summarizing article
open access
published version
2024
,Future Medicinal Chemistry
,16
(6)
Increasing resistance in Staphylococcus aureus has created a critical need for new drugs, especially those effective against methicillin-resistant strains (methicillin-resistant Staphylococcus aureus [MRSA]). Sulfonamides ...
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Large-Scale Development of Antibacterial Scaffolds: Gentamicin Sulfate-Loaded Biodegradable Nanofibers for Gastrointestinal Applications
original article
open access
published version
2023
,ACS Omega
,8
(43)
The ever-increasing demands of modern medicine drive the development of novel drug delivery materials. In particular, nanofibers are promising for such materials due to their favorable properties. However, most development ...
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Novel pyrimidine-1,3,4-oxadiazole hybrids and their precursors as potential antimycobacterial agents
original article
open access
published version
2023
,Future Medicinal Chemistry
,15
(12)
Background: Molecular hybridization and isostery are proven approaches in medicinal chemistry, and as such we used them to design novel compounds that we investigated as potential antimycobacterials to combat drug-resistant ...
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