2. lékařská fakulta
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Genomic DNA-based measurable residual disease monitoring in pediatric acute myeloid leukemia: unselected consecutive cohort study
(2024)Measurable residual disease (MRD) monitoring in childhood acute myeloid leukemia (AML) is used to assess response to treatment and for early detection of imminent relapse. In childhood AML, MRD is typically evaluated using ... -
Targeted DNA sequencing of high-grade serous ovarian carcinoma reveals association of TP53 mutations with platinum resistance when combined with gene expression
(2024)High-grade serous ovarian carcinoma (HGSC) is the most common subtype of ovarian cancer and is among the most fatal gynecological malignancies worldwide, due to late diagnosis at advanced stages and frequent therapy ... -
Integrated genomic analysis reveals actionable targets in pediatric spinal cord low-grade gliomas
(2022)Gliomas are the most common central nervous tumors in children and adolescents. However, spinal cord low-grade gliomas (sLGGs) are rare, with scarce information on tumor genomics and epigenomics. To define the molecular ... -
Renal denervation improves cardiac function independently of afterload and restores myocardial norepinephrine levels in a rodent heart failure model
(2024)Renal nerves play a critical role in cardiorenal interactions. Renal denervation (RDN) improved survival in some experimental heart failure (HF) models. It is not known whether these favorable effects are indirect, explainable ... -
The differences in virome from distinct anatomical locations in psoriasis patients
(Česká zemědělská univerzita, Praha, 2024)Psoriasis, a chronic autoimmune inflammatory disorder affecting 2-3% of the global population,exhibits a multifactorial aetiology with a significant genetic component and triggers such as trauma orinfection. -
Examining the Correlation Between Neurofilament Levels and Clinical Features in a Friedreich Ataxia Cohort from the Czech Republic
(2023)Objective: Friedreich's ataxia (FA) is the most common autosomal recessive hereditary ataxia caused by a mutation in the FXNgene characterized by ataxia, dorsal root syndrome, scoliosis, cardiomyopathy, and other symptoms. ... -
Longitudinal progression of choroid plexus enlargement is associated with female sex, cognitive decline and ApoE E4 homozygote status
(2023)INTRODUCTION: Choroid plexus (CP)-related mechanisms have been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease. In this pilot study, we aimed to elucidate the association between ... -
Microdialysis as a tool for antibiotic assessment in patients with diabetic foot: a review
(2023)Diabetic foot is a serious late complication frequently caused by infection and ischaemia. Both require prompt and aggressive treatment to avoid lower limb amputation. The effectiveness of peripheral arterial disease therapy ... -
Impaired renal autoregulation and pressure-natriuresis: any role in the development of heart failure in normotensive and angiotensin II-dependent hypertensive rats?
(2023)The aim of the present study was to assess the autoregulatory capacity of renal blood flow (RBF) and of the pressure-natriuresis characteristics in the early phase of heart failure (HF) in rats, normotensive and with ... -
Posttreatment positivity of BCR::ABL1 in acute lymphoblastic leukemia: Should we keep track?
(2023)We read with a great interest the paper focused on different minimal residual disease (MRD) approaches and its significance in Ph+ acute lymphoblastic leukemia (ALL) patients, authored by Short et al. from the MD Anderson ... -
Chimeric JAK2 Kinases Trigger Non-uniform Changes of Cellular Metabolism in BCR-ABL1-like Childhood ALL
(2023)We studied the impact of JAK2 fusions on metabolic rewiring of leukemic cells; we chose two representatives, themost frequent fusion and a novel previously undescribed fusion, and we showed that JAK2 fusions indeed alter ... -
Hybrid Macromolecular Constructs as a Platform for Spectral Nanoprobes for Advanced Cellular Barcoding in Flow Cytometry
(2024)Herein, an advanced bioconjugation technique to synthesize hybrid polymer-antibody nanoprobes tailored for fluorescent cell barcoding in flow cytometry-based immunophenotyping of leukocytes is applied. A novel approach of ... -
The KMT2A recombinome of acute leukemias in 2023
(2023)Chromosomal rearrangements of the human KMT2A/MLL gene are associated with de novo as well as therapy-induced infant, pediatric, and adult acute leukemias. Here, we present the data obtained from 3401 acute leukemia patients ... -
Effects of Lactiplantibacillus plantarum and Lacticaseibacillus paracasei supplementation on the single-cell fecal parasitome in children with celiac disease autoimmunity: a randomized, double-blind placebo-controlled clinical trial
(2023)BACKGROUND: Lactiplantibacillus plantarum HEAL9 and Lacticaseibacillus paracasei 8700:2 positively affect the fecal bacteriome in children with celiac disease autoimmunity after 6 months of supplementation. The aim of the ... -
A failure of Fourier transform infrared spectroscopy to type Burkholderia isolates from chronically infected patients with cystic fibrosis
(2023)We noted high variability of isolates spectra that prevented assigning isolates to known ST. Moreover, the FT-IR failed to reliably determine whether a chronic patient harbored the same Burkholderia strain over the course ... -
Direct 16S/18S rRNA Gene PCR Followed by Sanger Sequencing as a Clinical Diagnostic Tool for Detection of Bacterial and Fungal Infections: a Systematic Review and Meta-Analysis
(2023)rRNA gene Sanger sequencing is being used for the identification of cultured pathogens. A new diagnostic approach is sequencing of uncultured samples by using the commercial DNA extraction and sequencing platform SepsiTest ... -
Faecal bacteriome and metabolome profiles associated with decreased mucosal inflammatory activity upon anti-TNF therapy in paediatric Crohn's disease
(2024)BACKGROUND AND AIMS: Treatment by anti-TNFα antibodies (anti-TNF) changes the dysbiotic faecal bacteriome in Crohn's disease (CD). However, it is not known whether these changes are due to decreasing mucosal inflammatory ... -
DIPG-like MYB-altered diffuse astrocytoma with durable response to intensive chemotherapy
(2023)Pontine gliomas represent difficult to treat entity due to the location and heterogeneous biology varying from indolent low-grade gliomas to aggressive diffuse intrinsic pontine glioma (DIPG). Making the correct tumor ... -
Th1/interferon-γ bias in 22q11.2 deletion syndrome is driven by memory T cells and exacerbated by IL-7
(2023)The aim of this study was to investigate the impact of thymic dysplasia on the phenotypic and functional characteristics of T cells in patients with 22q11.2 deletion syndrome, including T-cell phenotype, transcriptional ... -
Variability of fluorescence intensity distribution measured by flow cytometry is influenced by cell size and cell cycle progression
(2023)The distribution of fluorescence signals measured with flow cytometry can be influenced by several factors, including qualitative and quantitative properties of the used fluorochromes, optical properties of the detection ...