Zobrazují se záznamy 1-20 z 100

    • Baseline and early changes in eosinophil count and neutrophil-to-eosinophil ratio predict outcomes in metastatic renal cell carcinoma treated with nivolumab 

      původní článek

      open access

      preprint

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      Fiala, Ondřej

      ;

      Rejleková, Katarína

      ;

      Büchler, Tomáš

      ;

      Študentová, Hana

      ;

      Poprach, Alexandr

      ;

      Vočka, Michal

      ;

      Hošek, Petr

      ;

      Kopecký, Jindřich

      ;

      Matějů, Martin

      ;

      Zemánková, Anežka

      ;

      Spisarová, Martina

      ;

      Tkadlecová, Michaela

      ;

      Priester, Peter

      ;

      Kouřil, Jan

      ;

      Lohynská, Radka

      ;

      Grmelová, Lucie

      ;

      Savka, Alexander

      ;

      Štefániková, Katarína

      ;

      Obertová, Jana

      ;

      Šiková, Dominika

      ;

      Stránský, Petr

      ;

      Melichar, Bohuslav

      ;

      Palacka, Patrik

      2025

      ,

      Springer Nature

      ,

      Scientific Reports

      The role of eosinophils in patients with cancer receiving systemic therapy based on immune checkpoint inhibitors (ICIs) has become a subject of increasing interest. The aim of the present study was to assess the prognostic ...

    • Genomic islands and molecular mechanisms relating to drug-resistance in Clostridioides (Clostridium) difficile PCR ribotype 176 

      původní článek

      open access

      vydavatelská verze

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      Krůtová, Marcela

      ;

      Kovarovic, Vojtech

      ;

      Brajerová, Marie

      ;

      Demay, Fanny

      ;

      Zíková, Jaroslava

      ;

      Prasad, Suhanya Veronica

      ;

      Soltesova, Anna

      ;

      Novakova, Elena

      ;

      Pituch, Hanna

      ;

      Kuijper, Ed

      ;

      Smits Wiep, Klaas

      ;

      Balikova Novotna, Gabriela

      2025

      ,

      Springer Nature

      ,

      Emerging Microbes & Infections

      ,

      14

      (1)

      OBJECTIVES: To analyse characteristics of Clostridioides difficile PCR ribotype 176 clinical isolates from Poland, the Czech Republic and Slovakia with regard to the differences in its epidemiology. METHODS: Antimicrobial ...

    • ESBL-producing and colistin-resistant Enterobacterales among Czech international travellers: genomic relatedness to community and environmental isolates 

      původní článek

      open access

      vydavatelská verze

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      Prasad, Suhanya Veronica

      ;

      Dratvová, Barbora

      ;

      Antušková, Milena

      ;

      Brajerová, Marie

      ;

      Nycova, Elka

      ;

      Adamová, Eva

      ;

      Trojánek, Milan

      ;

      Tkadlec, Jan

      ;

      Dřevínek, Pavel

      ;

      Krůtová, Marcela

      2025

      ,

      Elsevier

      ,

      Travel Medicine and Infectious Disease

      ,

      68

      (November–December)

      BACKGROUND: While antimicrobial resistance in Enterobacterales is closely monitored in healthcare settings, much less is known about the circulation of these bacteria in the community, particularly in high-risk groups such ...

    • Minimal residual disease assessment following CD19-targeted therapy in B-cell precursor acute lymphoblastic leukemia using standardized 12-color flow cytometry: A EuroFlow study 

      původní článek

      open access

      vydavatelská verze

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      Verbeek, Martijn W C

      ;

      Reiterová, Michaela

      ;

      Laqua, Anna

      ;

      Rodríguez, Beatriz Soriano

      ;

      Sedek, Lukasz

      ;

      Buracchi, Chiara

      ;

      Buysse, Malicorne

      ;

      Oliveira, Elen

      ;

      Engelmann, Robby

      ;

      Desterro, Joana

      ;

      De Jong, Anja X

      ;

      Boettcher, Sebastian

      ;

      Jugooa, Romana

      ;

      Barrena, Susana

      ;

      Kohlscheen, Saskia

      ;

      Nierkens, Stefan

      ;

      Rodriques, Joana G

      ;

      Hofmans, Mattias

      ;

      Gaipa, Giuseppe

      ;

      Sobral de Costa, Elaine

      ;

      Mejstříková, Ester

      ;

      Szczepanski, Tomasz

      ;

      Brüggemann, Monika

      ;

      van Dongen, Jacques J M

      ;

      Orfao, Alberto

      ;

      van der Velden, Vincent H J

      2025

      ,

      Wolters Kluwer Health, Inc.

      ,

      HemaSphere

      ,

      9

      (4)

      Detection of minimal/measurable residual disease (MRD) is a critical prognostic marker in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). The EuroFlow Consortium previously developed an 8-color flow cytometric MRD ...

    • Molecular Landscape of Pediatric Low-Grade Gliomas: Insights From RNA-NGS and Bioinformatic Analysis 

      původní článek

      open access

      vydavatelská verze

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      Brož, Petr

      ;

      Strnadová, Martina

      ;

      Olejníková, Denisa

      ;

      Kotiš, Johana

      ;

      Pospíšilíková, Tereza

      ;

      Mišove, Adéla

      ;

      Koblížek, Miroslav

      ;

      Zámečník, Josef

      ;

      Zápotocký, Michal

      ;

      Sumerauer, David

      ;

      Vícha, Aleš

      ;

      Kynčl, Martin

      ;

      Libý, Petr

      ;

      Beneš, Vladimír

      ;

      Krsková, Lenka

      2025

      ,

      Wiley-Liss, Inc.

      ,

      Genes, Chromosomes & Cancer

      ,

      64

      (10)

      Pediatric low-grade gliomas (pLGG) are the most common group of childhood brain tumors. Genetic alterations in the RAS-RAF-mitogen-activated protein kinase (MAPK) pathway are the molecular drivers in the vast majority of ...

    • Flow-cytometric MRD detection in pediatric T-ALL: a multicenter AIEOP-BFM consensus-based guided standardized approach 

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      open access

      vydavatelská verze

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      Reiterová, Michaela

      ;

      Kohlscheen, Saskia

      ;

      Maglia, Oscar

      ;

      Sala, Simona

      ;

      Schumich, Angela

      ;

      Maurer-Granofszky, Margarita

      ;

      Faggin, Giovanni

      ;

      Scarparo, Pamela

      ;

      Varotto, Elena

      ;

      Šestáková, Zuzana

      ;

      Švec, Peter

      ;

      Feuerstein, Tamar

      ;

      Vernitsky, Helly

      ;

      Kužílková, Daniela

      ;

      Hrušák, Ondřej

      ;

      Buldini, Barbara

      ;

      Dworzak, Michael

      ;

      Brüggemann, Monika

      ;

      Gaipa, Giuseppe

      ;

      Kalina, Tomáš

      2025

      ,

      de Gruyter

      ,

      Clinical Chemistry and Laboratory Medicine

      ,

      63

      (7)

      OBJECTIVES: Risk-based stratification approaches using measurable residual disease (MRD) successfully help to identify T-acute lymphoblastic leukemia (T-ALL) patients at risk of relapse, whose treatment outcomes are very ...

    • NGS-MRD negativity in post-HSCT ALL spares unnecessary therapeutic interventions triggered by borderline qPCR results without an increase in relapse risk 

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      open access

      vydavatelská verze

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      Šeferna, Kryštof

      ;

      Svatoň, Michael

      ;

      Rennerová, Andrea

      ;

      Skotnicová, Aneta

      ;

      Řezníčková, Leona

      ;

      Valová, Taťána

      ;

      Sedláček, Petr

      ;

      Říha, Petr

      ;

      Formánková, Renata

      ;

      Keslová, Petra

      ;

      Šrámková, Lucie

      ;

      Starý, Jan

      ;

      Zuna, Jan

      ;

      Kolenova, Alexandra

      ;

      Šálek, Cyril

      ;

      Trka, Jan

      ;

      Froňková, Eva

      2025

      ,

      HemaSphere

      ,

      9

      (4)

      Monitoring of minimal residual disease (MRD) after hematopoietic stem cell transplantation (HSCT) in patients with acute lymphoblastic leukemia (ALL) is vital for timely therapeutic intervention planning. However, interpreting ...

    • Dysregulated mitochondrial homeostasis and DNA repair in the progression from colon adenoma to cancer 

      původní článek

      open access

      postprint

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      Danešová, Natálie

      ;

      Horak, Josef

      ;

      Valíčková, Anna

      ;

      Gil-Korilis, Adrian

      ;

      Ergui-Arbizu, Jorge

      ;

      Pálek, Richard

      ;

      Brůha, Jan

      ;

      Levý, Miroslav

      ;

      Škrobánek, Pavel

      ;

      Král, Jan

      ;

      Jungwirth, Jiří

      ;

      Neužil, Jiří

      ;

      Vymetálková, Veronika

      ;

      Vodička, Pavel

      ;

      Vodenková, Soňa

      ;

      Tomášová, Kristýna

      2025

      ,

      North Shore-Long Island Jewish Research Institute

      ,

      Molecular Medicine

      BACKGROUND: While nuclear DNA (nDNA) damage and alterations in nDNA repair are known to play a role in colon cancer (CC), there is insufficient research investigating these processes in mitochondrial DNA (mtDNA). METHODS: ...

    • Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions 

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      open access

      vydavatelská verze

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      Lamoureux, Audrey-Anne

      ;

      Fisher, Michael J

      ;

      Lemelle, Lauriane

      ;

      Pfaff, Elke

      ;

      Amir-Yazdani, Pouneh

      ;

      Kramm, Christof

      ;

      De Wilde, Bram

      ;

      Kazanowska, Bernarda

      ;

      Hutter, Caroline

      ;

      Pfister, Stefan M

      ;

      Sturm, Dominik

      ;

      Jones, David T W

      ;

      Orbach, Daniel

      ;

      Pierron, Gaëlle

      ;

      Raskin, Scott

      ;

      Drilon, Alexander

      ;

      Diamond, Eli L

      ;

      Harada, Guilherme

      ;

      Zápotocký, Michal

      ;

      Zámečník, Josef

      ;

      Krsková, Lenka

      ;

      Ellezam, Benjamin

      ;

      Weil, Alexander G

      ;

      Venne, Dominic

      ;

      Barritault, Marc

      ;

      Leblond, Pierre

      ;

      Coltin, Hallie

      ;

      Hammad, Rawan

      ;

      Tabori, Uri

      ;

      Hawkins, Cynthia

      ;

      Hansford, Jordan R

      ;

      Meyran, Deborah

      ;

      Erker, Craig

      ;

      McFadden, Kathryn

      ;

      Sato, Mariko

      ;

      Gottardo, Nicholas G

      ;

      Dholaria, Hetal

      ;

      Nørøxe, Dorte Schou

      ;

      Goto, Hiroaki

      ;

      Ziegler, David S

      ;

      Lin, Frank Y

      ;

      Parsons, Donald Williams

      ;

      Lindsay, Holly

      ;

      Wong, Tai-Tong

      ;

      Liu, Yen-Lin

      ;

      Wu, Kuo-Sheng

      ;

      Franson, Andrea T

      ;

      Hwang, Eugene

      ;

      Aguilar-Bonilla, Ana

      ;

      Cheng, Sylvia

      ;

      Cacciotti, Chantel

      ;

      Massimino, Maura

      ;

      Schiavello, Elisabetta

      ;

      Wood, Paul

      ;

      Hoffman, Lindsey M

      ;

      Cappellano, Andréa

      ;

      Lassaletta, Alvaro

      ;

      Van Damme, An

      ;

      Llort, Anna

      ;

      Gerber, Nicolas U

      ;

      Spalato Ceruso, Mariella

      ;

      Bendel, Anne E

      ;

      Skrypek, Maggie

      ;

      Hamideh, Dima

      ;

      Mushtaq, Naureen

      ;

      Walter, Andrew

      ;

      Jabado, Nada

      ;

      Alsahlawi, Aysha

      ;

      Farmer, Jean-Pierre

      ;

      Coleman, Christina

      ;

      Mueller, Sabine

      ;

      Mazewski, Claire

      ;

      Aguilera, Dolly

      ;

      Robison, Nathan J

      ;

      O'Halloran, Katrina

      ;

      Abbou, Samuel

      ;

      Berlanga, Pablo

      ;

      Geoerger, Birgit

      ;

      Øra, Ingrid

      ;

      Moertel, Christopher L

      ;

      Razis, Evangelia D

      ;

      Vernadou, Anastasia

      ;

      Ducray, François

      ;

      Bronnimann, Charlotte

      ;

      Seizeur, Romuald

      ;

      Clarke, Matthew

      ;

      Resnick, Adam C

      ;

      Alves, Mélanie

      ;

      Jones, Chris

      ;

      Doz, François

      ;

      Laetsch, Theodore W

      ;

      Perreault, Sébastien

      2025

      ,

      American Association for Cancer Research

      ,

      Clinical Cancer Research

      ,

      31

      (3)

      PURPOSE: TRK fusions are detected in less than 2% of central nervous system tumors. There are limited data on the clinical course of affected patients. EXPERIMENTAL DESIGN: We conducted an international retrospective cohort ...

    • Changes of abdominal wall tension across various resistance exercises during maximal and submaximal loads in healthy adults: a cross-sectional study 

      původní článek

      open access

      vydavatelská verze

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      Juřík, Roman

      ;

      Šťastný, Petr

      ;

      Kolinger, Dominik

      ;

      Větrovský, Tomáš

      ;

      Novák, Jakub

      ;

      Kobesová, Alena

      ;

      Krzysztofik, Michal

      ;

      Busch, Andrew

      2025

      ,

      BioMed Central

      ,

      BMC Sports Science, Medicine and Rehabilitation

      ,

      17

      (1)

      INTRODUCTION: Resistance exercises are effective for maintaining health and activating stabilizing muscles, as they trigger abdominal wall tension responses. This study compared the effects of multi-joint and single-joint, ...

    • Preoccupied and Fearful-Avoidant Attachment Styles May Mediate the Relationship Between Poor Parental Relationship Quality and Sexual Interests in Violence 

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      open access

      vydavatelská verze

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      Zakreski, Ellen

      ;

      Jahnke, Sara

      ;

      Androvičová, Renáta

      ;

      Bártová, Klára

      ;

      Chronos, Agatha

      ;

      Krejčová, Lucie

      ;

      Martinec Nováková, Lenka

      ;

      Klapilová, Kateřina

      2025

      ,

      Archives of Sexual Behavior

      ,

      54

      (7)

      Research suggests that adverse rearing conditions such as poor-quality relations with one's parents are associated with a range of potentially problematic sexual behaviors and interests. Less is known, however, about the ...

    • Recurrence following invasive GAS infections in adults: Triumph of virulence or failure of immunity? 

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      open access

      vydavatelská verze

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      Štefan, Marek

      ;

      Brajerová, Marie

      ;

      Prasad, Suhanya Veronica

      ;

      Bébrová, Eliška

      ;

      Beroušek, Jan

      ;

      Pozniak, Jiří

      ;

      Jaroščiaková, Silvia

      ;

      Rennerová, Andrea

      ;

      Milota, Tomáš

      ;

      Nyč, Otakar

      ;

      Dřevínek, Pavel

      ;

      Krůtová, Marcela

      ;

      Trojánek, Milan

      2025

      ,

      Landes Bioscience

      ,

      Virulence

      ,

      16

      (1)

      Since late 2022, an increase in Streptococcus pyogenes (Group A Streptococcus, GAS) infections, both non-invasive and invasive (iGAS), has been reported globally. This study investigates iGAS cases complicated by recurrent ...

    • Neural Dynamics of Visual Stream Interactions During Memory-Guided Actions Investigated by Intracranial EEG 

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      open access

      vydavatelská verze

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      Moraresku, Sofia

      ;

      Hammer, Jiří

      ;

      Dimakopoulos, Vasileios

      ;

      Kajšová, Michaela

      ;

      Janča, Radek

      ;

      Ježdík, Petr

      ;

      Kalina, Adam

      ;

      Marusič, Petr

      ;

      Vlček, Kamil

      2025

      ,

      Neuroscience Bulletin

      ,

      41

      (8)

      The dorsal and ventral visual streams have been considered to play distinct roles in visual processing for action: the dorsal stream is assumed to support real-time actions, while the ventral stream facilitates memory-guided ...

    • Impact of concomitant use of proton pump inhibitors or cardiovascular medication on survival outcomes of patients with metastatic renal cell carcinoma treated with nivolumab 

      původní článek

      open access

      vydavatelská verze

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      Fiala, Ondřej

      ;

      Hošek, Petr

      ;

      Tkadlecová, Michaela

      ;

      Melichar, Bohuslav

      ;

      Zemánková, Anežka

      ;

      Kopecký, Jindřich

      ;

      Vočka, Michal

      ;

      Matějů, Martin

      ;

      Lohynská, Radka

      ;

      Šiková, Dominika

      ;

      Stránský, Petr

      ;

      Študentová, Hana

      ;

      Spisarová, Martina

      ;

      Nováková, Hana

      ;

      Priester, Peter

      ;

      Kryštofová, Dominika

      ;

      Grmelová, Lucie

      ;

      Büchler, Tomáš

      ;

      Poprach, Alexandr

      2025

      ,

      Clinical & Experimental Metastasis

      ,

      42

      (5)

      Renal cell cancer (RCC) is typically a disease of older adults, who often have comorbidities requiring the use of multiple concomitant medications. Even though the patients with metastatic RCC (mRCC) are often exposed to ...

    • Integrative miRNOMe profiling reveals the miR-195-5p–CHEK1 axis and its impact on luminal breast cancer outcomes 

      původní článek

      open access

      vydavatelská verze

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      Boušková, Veronika

      ;

      Ehrlichová, Marie

      ;

      Spálenková, Alžběta

      ;

      Krus, Ivona

      ;

      Šůsová, Simona

      ;

      Hlaváč, Viktor

      ;

      Němcová, Vlasta

      ;

      Koževnikovová, Renata

      ;

      Trnková, Markéta

      ;

      Vrána, David

      ;

      Gatěk, Jiří

      ;

      Kopečková, Kateřina

      ;

      Mrhalová, Marcela

      ;

      Měšťáková, Soňa

      ;

      Souček, Pavel

      2025

      ,

      John Wiley & Sons

      ,

      Molecular Oncology

      ,

      19

      (11)

      The luminal subtype (estrogen receptor-positive, ER+) is the most common and the most heterogeneous type of breast carcinoma (BC) in women. During our study, we determined expression levels of all microRNAs (miRNome) in ...

    • Genetic Testing for Malformations of Cortical Development 

      původní článek

      omezený přístup

      vydavatelská verze

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      Straka, Barbora

      ;

      Heřmanovská, Barbora

      ;

      Krsková, Lenka

      ;

      Zámečník, Josef

      ;

      Vlčková, Markéta

      ;

      Balaščaková, Miroslava

      ;

      Tesner, Pavel

      ;

      Jezdik, Petr

      ;

      Tichý, Michal

      ;

      Kynčl, Martin

      ;

      Musilová, Alena

      ;

      Laššuthová, Petra

      ;

      Marusič, Petr

      ;

      Kršek, Pavel

      ;

      Kudr, Martin

      ;

      Bělohlávková, Anežka

      ;

      Ebel, Matyáš

      ;

      Jahodová, Alena

      ;

      Kalinová, Markéta

      ;

      Novak, Vilem

      ;

      Rivera, Gonzalo Alonso Ramos

      ;

      Staněk, David

      ;

      Libý, Petr

      ;

      Kalina, Adam

      ;

      Zárubová, Jana

      ;

      Uhrová Mészárosová, Anna

      ;

      Maulisová, Alice

      ;

      Zůnová, Hana

      ;

      Koblížek, Miroslav

      2022

      ,

      Neurology. Genetics

      ,

      8

      (5)

      Background and Objectives. Malformations of cortical development (MCD), though individually rare, constitute a significant burden of disease. The diagnostic yield of next-generation sequencing (NGS) in these patients varies ...

    • Is autism driven by epilepsy in infants with Tuberous Sclerosis Complex? 

      původní článek

      open access

      vydavatelská verze

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      Moavero, Romina

      ;

      Kotulska, Katarzyna

      ;

      Lagae, Lieven

      ;

      Benvenuto, Arianna

      ;

      Emberti Gialloreti, Leonardo

      ;

      Weschke, Bernhard

      ;

      Riney, Kate

      ;

      Feucht, Martha

      ;

      Kršek, Pavel

      ;

      Nabbout, Rima

      ;

      Jansen, Anna C

      ;

      Wojdan, Konrad

      ;

      Borkowska, Julita

      ;

      Sadowski, Krzysztof

      ;

      Hertzberg, Christoph

      ;

      Van Schooneveld, Monique M

      ;

      Samueli, Sharon

      ;

      Maulisová, Alice

      ;

      Aronica, Eleonora

      ;

      Kwiatkowski, David J

      ;

      Jansen, Floor E

      ;

      Jozwiak, Sergiusz

      ;

      Curatolo, Paolo

      2020

      ,

      Annals of Clinical and Translational Neurology [online]

      ,

      7

      (8)

      OBJECTIVE: To evaluate the relationship between age at seizure onset and neurodevelopmental outcome at age 24 months in infants with TSC, as well as the effect on neurodevelopmental outcome of early versus conventional ...

    • miRNAs and isomiRs: Serum-Based Biomarkers for the Development of Intellectual Disability and Autism Spectrum Disorder in Tuberous Sclerosis Complex 

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      open access

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      Scheper, Mirte

      ;

      Romagnolo, Alessia

      ;

      Besharat, Zein Mersini

      ;

      Iyer, Anand M

      ;

      Moavero, Romina

      ;

      Hertzberg, Christoph

      ;

      Weschke, Bernhard

      ;

      Riney, Kate

      ;

      Feucht, Martha

      ;

      Scholl, Theresa

      ;

      Petrák, Bořivoj

      ;

      Maulisová, Alice

      ;

      Nabbout, Rima

      ;

      Jansen, Anna C

      ;

      Jansen, Floor E

      ;

      Lagae, Lieven

      ;

      Urbanska, Malgorzata

      ;

      Ferretti, Elisabetta

      ;

      Tempes, Aleksandra

      ;

      Blazejczyk, Magdalena

      ;

      Jaworski, Jacek

      ;

      Kwiatkowski, David J

      ;

      Jozwiak, Sergiusz

      ;

      Kotulska, Katarzyna

      ;

      Sadowski, Krzysztof

      ;

      Borkowska, Julita

      ;

      Curatolo, Paolo

      ;

      Mills, James D

      ;

      Aronica, Eleonora

      2022

      ,

      Biomedicines [online]

      ,

      10

      (8)

      Tuberous sclerosis complex (TSC) is a rare multi-system genetic disorder characterized by a high incidence of epilepsy and neuropsychiatric manifestations known as tuberous-sclerosis-associated neuropsychiatric disorders ...

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      Wang, He-Ling

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      Unhealthy ageing poses a global challenge with profound healthcare and socioeconomic implications. Slowing down the ageing process offers a promising approach to reduce the burden of a number of age-related diseases, such ...

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      Hoffmann, Luisa

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      Kohls, Mirjam

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      Arnolds, Stefanie

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      INTRODUCTION: The identification of type 1 diabetes at an early presymptomatic stage has clinical benefits. These include a reduced risk of diabetic ketoacidosis (DKA) at the clinical manifestation of the disease and a ...