Zobrazují se záznamy 21-40 z 61

    • Microdialysis as a tool for antibiotic assessment in patients with diabetic foot: a review 

      přehledový článek

      embargo

      vydavatelská verze

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      Fejfarová, Vladimíra

      ;

      Jarošíková, Radka

      ;

      Polák, Jan

      ;

      Sommerová, Blanka

      ;

      Husáková, Jitka

      ;

      Wosková, Veronika

      ;

      Dubský, Michal

      ;

      Tůma, Petr

      2023

      ,

      Frontiers in Endocrinology

      ,

      14

      (April)

      Diabetic foot is a serious late complication frequently caused by infection and ischaemia. Both require prompt and aggressive treatment to avoid lower limb amputation. The effectiveness of peripheral arterial disease therapy ...

    • Impaired renal autoregulation and pressure-natriuresis: any role in the development of heart failure in normotensive and angiotensin II-dependent hypertensive rats? 

      původní článek

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      Honetschlägerová, Zuzana

      ;

      Sadowski, Janusz

      ;

      Kompanowska-Jezierska, Elzbieta

      ;

      Maxová, Hana

      ;

      Táborský, Miloš

      ;

      Kujal, Petr

      ;

      Červenka, Luděk

      2023

      ,

      Hypertension Research

      ,

      46

      (9)

      The aim of the present study was to assess the autoregulatory capacity of renal blood flow (RBF) and of the pressure-natriuresis characteristics in the early phase of heart failure (HF) in rats, normotensive and with ...

    • Posttreatment positivity of BCR::ABL1 in acute lymphoblastic leukemia: Should we keep track? 

      letter to the editors

      embargo

      postprint

      Ikona Jiná licence

      Zuna, Jan

      ;

      Hovorková, Lenka

      ;

      Krotká, Justina

      ;

      Winkowska, Lucie

      ;

      Novak, Zbynek

      ;

      Šrámková, Lucie

      ;

      Starý, Jan

      ;

      Trka, Jan

      ;

      Cazzaniga, Giovanni

      ;

      Cario, Gunnar

      ;

      Žaliová, Markéta

      2023

      ,

      American Journal of Hematology

      ,

      98

      (10)

      We read with a great interest the paper focused on different minimal residual disease (MRD) approaches and its significance in Ph+ acute lymphoblastic leukemia (ALL) patients, authored by Short et al. from the MD Anderson ...

    • Chimeric JAK2 Kinases Trigger Non-uniform Changes of Cellular Metabolism in BCR-ABL1-like Childhood ALL 

      letter to the editors

      open access

      vydavatelská verze

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      Lukeš, Julius

      ;

      Potůčková, Eliška

      ;

      Alquezar Artieda, Natividad

      ;

      Heřmanová, Ivana

      ;

      Kosanovic, Sladjana

      ;

      Hložková, Kateřina

      ;

      Alberich Jorda, Meritxell

      ;

      Zuna, Jan

      ;

      Trka, Jan

      ;

      Tennant, Daniel A

      ;

      Stanulla, Martin

      ;

      Žaliová, Markéta

      ;

      Starková, Júlia

      2023

      ,

      HemaSphere

      ,

      7

      (9)

      We studied the impact of JAK2 fusions on metabolic rewiring of leukemic cells; we chose two representatives, themost frequent fusion and a novel previously undescribed fusion, and we showed that JAK2 fusions indeed alter ...

    • Hybrid Macromolecular Constructs as a Platform for Spectral Nanoprobes for Advanced Cellular Barcoding in Flow Cytometry 

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      Kudláčová, Júlia

      ;

      Kužílková, Daniela

      ;

      Bárta, František

      ;

      Brdičková, Naděžda

      ;

      Vávrová, Adéla

      ;

      Kostka, Libor

      ;

      Hovorka, Ondřej

      ;

      Kalina, Tomáš

      ;

      Etrych, Tomáš

      2024

      ,

      Macromolecular Bioscience

      ,

      24

      (2)

      Herein, an advanced bioconjugation technique to synthesize hybrid polymer-antibody nanoprobes tailored for fluorescent cell barcoding in flow cytometry-based immunophenotyping of leukocytes is applied. A novel approach of ...

    • The KMT2A recombinome of acute leukemias in 2023 

      původní článek

      open access

      vydavatelská verze

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      Meyer, C

      ;

      Larghero, P

      ;

      Almeida Lopes, B

      ;

      Burmeister, T

      ;

      Gröger, D

      ;

      Sutton, R

      ;

      Venn, N C

      ;

      Cazzaniga, G

      ;

      Corral Abascal, L

      ;

      Tsaur, G

      ;

      Fechina, L

      ;

      Emerenciano, M

      ;

      Pombo-de-Oliveira, M S

      ;

      Lund-Aho, T

      ;

      Lundán, T

      ;

      Montonen, M

      ;

      Juvonen, V

      ;

      Zuna, Jan

      ;

      Trka, Jan

      ;

      Ballerini, P

      ;

      Lapillonne, H

      ;

      Van der Velden, V H J

      ;

      Sonneveld, E

      ;

      Delabesse, E

      ;

      de Matos, R R C

      ;

      Silva, M L M

      ;

      Bomken, S

      ;

      Katsibardi, K

      ;

      Keernik, M

      ;

      Grardel, N

      ;

      Mason, J

      ;

      Price, R

      ;

      Kim, J

      ;

      Eckert, C

      ;

      Lo Nigro, L

      ;

      Bueno, C

      ;

      Menendez, P

      ;

      Zur Stadt, U

      ;

      Gameiro, P

      ;

      Sedék, L

      ;

      Szczepański, T

      ;

      Bidet, A

      ;

      Marcu, V

      ;

      Shichrur, K

      ;

      Izraeli, S

      ;

      Madsen, H O

      ;

      Schäfer, B W

      ;

      Kubetzko, S

      ;

      Kim, R

      ;

      Clappier, E

      ;

      Trautmann, H

      ;

      Brüggemann, M

      ;

      Archer, P

      ;

      Hancock, J

      ;

      Alten, J

      ;

      Möricke, A

      ;

      Stanulla, M

      ;

      Lentes, J

      ;

      Bergmann, A K

      ;

      Strehl, S

      ;

      Köhrer, S

      ;

      Nebral, K

      ;

      Dworzak, M N

      ;

      Haas, O A

      ;

      Arfeuille, C

      ;

      Caye-Eude, A

      ;

      Cavé, H

      ;

      Marschalek, R

      2023

      ,

      Leukemia

      ,

      37

      (5)

      Chromosomal rearrangements of the human KMT2A/MLL gene are associated with de novo as well as therapy-induced infant, pediatric, and adult acute leukemias. Here, we present the data obtained from 3401 acute leukemia patients ...

    • Effects of Lactiplantibacillus plantarum and Lacticaseibacillus paracasei supplementation on the single-cell fecal parasitome in children with celiac disease autoimmunity: a randomized, double-blind placebo-controlled clinical trial 

      původní článek

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      Hurych, Jakub

      ;

      Oscarsson, Elin

      ;

      Håkanson, Åsa

      ;

      Jirků-Pomajbíková, Kateřina

      ;

      Jirků, Milan

      ;

      Aronson, Carin Andrén

      ;

      Cinek, Ondřej

      ;

      Agardh, Daniel

      2023

      ,

      Parasites & Vectors

      ,

      16

      (1)

      BACKGROUND: Lactiplantibacillus plantarum HEAL9 and Lacticaseibacillus paracasei 8700:2 positively affect the fecal bacteriome in children with celiac disease autoimmunity after 6 months of supplementation. The aim of the ...

    • A failure of Fourier transform infrared spectroscopy to type Burkholderia isolates from chronically infected patients with cystic fibrosis 

      letter to the editors

      open access

      postprint

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      Tkadlec, Jan

      ;

      Prášilová, Jana

      ;

      Dřevínek, Pavel

      2023

      ,

      Microbiology spectrum

      ,

      11

      (6)

      We noted high variability of isolates spectra that prevented assigning isolates to known ST. Moreover, the FT-IR failed to reliably determine whether a chronic patient harbored the same Burkholderia strain over the course ...

    • Direct 16S/18S rRNA Gene PCR Followed by Sanger Sequencing as a Clinical Diagnostic Tool for Detection of Bacterial and Fungal Infections: a Systematic Review and Meta-Analysis 

      přehledový článek

      open access

      vydavatelská verze

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      Dřevínek, Pavel

      ;

      Hollweck, Regina

      ;

      Lorenz, Michael G

      ;

      Lustig, Michael

      ;

      Bjarnsholt, Thomas

      2023

      ,

      Journal of Clinical Microbiology

      ,

      61

      (9)

      rRNA gene Sanger sequencing is being used for the identification of cultured pathogens. A new diagnostic approach is sequencing of uncultured samples by using the commercial DNA extraction and sequencing platform SepsiTest ...

    • Faecal bacteriome and metabolome profiles associated with decreased mucosal inflammatory activity upon anti-TNF therapy in paediatric Crohn's disease 

      původní článek

      open access

      vydavatelská verze

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      Hurych, Jakub

      ;

      Mascellani Bergo, Anna

      ;

      Lerchová, Tereza

      ;

      Hlináková, Lucie

      ;

      Kubát, Michal

      ;

      Malcová, Hana

      ;

      Cebecauerová, Dita

      ;

      Schwarz, Jan

      ;

      Karaskova, Eva

      ;

      Hecht, Tomáš

      ;

      Vyhnánek, Radim

      ;

      Toukalkova, Lenka

      ;

      Dotlačil, Vojtěch

      ;

      Greinerova, Katerina

      ;

      Cizkova, Anabela

      ;

      Horváth, Rudolf

      ;

      Bronský, Jiří

      ;

      Havlik, Jaroslav

      ;

      Hradský, Ondřej

      ;

      Cinek, Ondřej

      2024

      ,

      Journal of Crohn's and Colitis

      ,

      18

      (1)

      BACKGROUND AND AIMS: Treatment by anti-TNFα antibodies (anti-TNF) changes the dysbiotic faecal bacteriome in Crohn's disease (CD). However, it is not known whether these changes are due to decreasing mucosal inflammatory ...

    • DIPG-like MYB-altered diffuse astrocytoma with durable response to intensive chemotherapy 

      kazuistika

      open access

      vydavatelská verze

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      Trková, Kateřina

      ;

      Sumerauer, David

      ;

      Krsková, Lenka

      ;

      Vícha, Aleš

      ;

      Koblížek, Miroslav

      ;

      Votava, Tomáš

      ;

      Přibáň, Vladimír

      ;

      Zápotocký, Michal

      2023

      ,

      Child's Nervous System

      ,

      39

      (9)

      Pontine gliomas represent difficult to treat entity due to the location and heterogeneous biology varying from indolent low-grade gliomas to aggressive diffuse intrinsic pontine glioma (DIPG). Making the correct tumor ...

    • Th1/interferon-γ bias in 22q11.2 deletion syndrome is driven by memory T cells and exacerbated by IL-7 

      původní článek

      open access

      vydavatelská verze

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      Vladyka, Ondřej

      ;

      Vrabcová, Petra

      ;

      Reiterová, Michaela

      ;

      Paračková, Zuzana

      ;

      Haesler, Robert

      ;

      Šedivá, Anna

      ;

      Kalina, Tomáš

      ;

      Klocperk, Adam

      2023

      ,

      Clinical Immunology

      ,

      256

      (November)

      The aim of this study was to investigate the impact of thymic dysplasia on the phenotypic and functional characteristics of T cells in patients with 22q11.2 deletion syndrome, including T-cell phenotype, transcriptional ...

    • Variability of fluorescence intensity distribution measured by flow cytometry is influenced by cell size and cell cycle progression 

      původní článek

      open access

      vydavatelská verze

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      Fedr, Radek

      ;

      Kahounová, Zuzana

      ;

      Remšík, Ján

      ;

      Reiterová, Michaela

      ;

      Kalina, Tomáš

      ;

      Souček, Karel

      2023

      ,

      Scientific Reports

      ,

      13

      (1)

      The distribution of fluorescence signals measured with flow cytometry can be influenced by several factors, including qualitative and quantitative properties of the used fluorochromes, optical properties of the detection ...

    • Does advanced maternal age explain the longer hospitalisation of mothers after childbirth? 

      původní článek

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      Šťastná, Anna

      ;

      Šídlo, Luděk

      ;

      Kocourková, Jiřina

      ;

      Fait, Tomáš

      2023

      ,

      PLoS One

      ,

      18

      (4)

      BACKGROUND: Fertility postponement, which has comprised the most significant reproductive trend in developed countries over the last few decades, involves a number of social, personal and health consequences. The length ...

    • Does Advanced Maternal Age Comprise an Independent Risk Factor for Caesarean Section? A Population-Wide Study 

      původní článek

      open access

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      Šťastná, Anna

      ;

      Fait, Tomáš

      ;

      Kocourková, Jiřina

      ;

      Waldaufová, Eva

      2023

      ,

      International Journal of Environmental Research and Public Health

      ,

      20

      (1)

      The paper aims to investigate the association between the mother's age and the risk of caesarean section when controlling for health factors and selected socio-demographic characteristics. The analysis employs anonymized ...

    • The detection of hypoxia markers in non-HPV and HPV-associated head and neck cancers: implications to patient survival 

      abstrakt v konferenčním sborníku

      open access

      vydavatelská verze

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      Šmahelová, Jana

      ;

      Pokrývková, Barbora

      ;

      Šťovíčková, Eliška

      ;

      Vencálek, Ondřej

      ;

      Šmahel, Michal

      ;

      Grega, Marek

      ;

      Klozar, Jan

      ;

      Tachezy, Ruth

      2023

      ,

      Czech Chemical Society Symposium Series

      ,

      21

      (5)

      In the microenvironment of growing solid tumors, oxygen level often decreases and a hypoxic state is induced. This can lead to a worse treatment response and poor patient prognosis. One of the hypoxia-responsive genes ...

    • Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukaemia 

      původní článek

      open access

      vydavatelská verze

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      Woodward, Eleanor L

      ;

      Yang, Minjun

      ;

      Moura-Castro, Larissa H

      ;

      van den Bos, Hilda

      ;

      Gunnarsson, Rebeqa

      ;

      Olsson-Arvidsson, Linda

      ;

      Spierings, Diana C J

      ;

      Castor, Anders

      ;

      Duployez, Nicolas

      ;

      Žaliová, Markéta

      ;

      Zuna, Jan

      ;

      Johansson, Bertil

      ;

      Foijer, Floris

      ;

      Paulsson, Kajsa

      2023

      ,

      Nature Communications

      ,

      14

      (1)

      High hyperdiploid acute lymphoblastic leukemia (HeH ALL), one of the most common childhood malignancies, is driven by nonrandom aneuploidy (abnormal chromosome numbers) mainly comprising chromosomal gains. In this study, ...

    • Constitutively active Lyn kinase causes a cutaneous small vessel vasculitis and liver fibrosis syndrome 

      původní článek

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      vydavatelská verze

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      de Jesus, Adriana A

      ;

      Chen, Guibin

      ;

      Yang, Dan

      ;

      Brdicka, Tomas

      ;

      Ruth, Natasha M

      ;

      Bennin, David

      ;

      Cebecauerová, Dita

      ;

      Malcová, Hana

      ;

      Freeman, Helen

      ;

      Martin, Neil

      ;

      Švojgr, Karel

      ;

      Passo, Murray H

      ;

      Bhuyan, Farzana

      ;

      Alehashemi, Sara

      ;

      Rastegar, Andre T

      ;

      Uss, Katsiaryna

      ;

      Kardava, Lela

      ;

      Marrero, Bernadette

      ;

      Đurić, Iris

      ;

      Omoyinmi, Ebun

      ;

      Peldová, Petra

      ;

      Lee, Chyi-Chia Richard

      ;

      Kleiner, David E

      ;

      Hadigan, Colleen M

      ;

      Hewitt, Stephen M

      ;

      Pittaluga, Stefania

      ;

      Carmona-Rivera, Carmelo

      ;

      Calvo, Katherine R

      ;

      Shah, Nirali

      ;

      Balaščaková, Miroslava

      ;

      Fink, Danielle L

      ;

      Kotalová, Radana

      ;

      Paračková, Zuzana

      ;

      Peterková, Lucie

      ;

      Kužílková, Daniela

      ;

      Campr, Vít

      ;

      Šrámková, Lucie

      ;

      Biancotto, Angelique

      ;

      Brooks, Stephen R

      ;

      Manes, Cameron

      ;

      Meffre, Eric

      ;

      Harper, Rebecca L

      ;

      Kuehn, Hyesun

      ;

      Kaplan, Mariana J

      ;

      Brogan, Paul

      ;

      Rosenzweig, Sergio D

      ;

      Merchant, Melinda

      ;

      Deng, Zuoming

      ;

      Huttenlocher, Anna

      ;

      Moir, Susan L

      ;

      Kuhns, Douglas B

      ;

      Boehm, Manfred

      ;

      Škvárová Kramarzová, Karolina

      ;

      Goldbach-Mansky, Raphaela

      2023

      ,

      Nature Communications

      ,

      14

      (1)

      Neutrophilic inflammation is a hallmark of many monogenic autoinflammatory diseases; pathomechanisms that regulate extravasation of damaging immune cells into surrounding tissues are poorly understood. Here we identified ...

    • Human polyomaviruses in psoriasis patients on biologic treatment 

      abstrakt v elektronické podobě

      open access

      postprint

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      Saláková, Martina

      ;

      Rob, Filip

      ;

      Hugo, Jan

      ;

      Šmahelová, Jana

      ;

      Hamšíková, Eva

      ;

      Ludvíková, Viera

      ;

      Gkalpakiotis, Spyridon

      ;

      Boháč, Petr

      ;

      Tachezy, Ruth

      2023

      ,

      Neuveden

      Biologic therapy poses a higher risk of viral infection for patients, however current knowledge of human polyomavirus infection in psoriasis patients is stilllimited. In this study, we evaluate the prevalence of BK ...

    • Minimal residual disease in BCR::ABL1-positive acute lymphoblastic leukemia: different significance in typical ALL and in CML-like disease 

      původní článek

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      Zuna, Jan

      ;

      Hovorková, Lenka

      ;

      Krotká, Justina

      ;

      Koehrmann, Amelie

      ;

      Bardini, Michela

      ;

      Winkowska, Lucie

      ;

      Froňková, Eva

      ;

      Alten, Julia

      ;

      Koehler, Rolf

      ;

      Eckert, Cornelia

      ;

      Brizzolara, Lisa

      ;

      Trkova, Marie

      ;

      Stuchlý, Jan

      ;

      Zimmermann, Martin

      ;

      De Lorenzo, Paola

      ;

      Valsecchi, Maria Grazia

      ;

      Conter, Valentino

      ;

      Starý, Jan

      ;

      Schrappe, Martin

      ;

      Biondi, Andrea

      ;

      Trka, Jan

      ;

      Žaliová, Markéta

      ;

      Cazzaniga, Giovanni

      ;

      Cario, Gunnar

      2022

      ,

      Leukemia

      ,

      36

      (23)

      Recently, we defined "CML-like" subtype of BCR::ABL1-positive acute lymphoblastic leukemia (ALL), resembling lymphoid blast crisis of chronic myeloid leukemia (CML). Here we retrospectively analyzed prognostic relevance ...