2. Faculty of Medicine: Poslední příspěvky
Zobrazují se záznamy 21-40 z 61
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Microdialysis as a tool for antibiotic assessment in patients with diabetic foot: a review
přehledový článek
embargo
vydavatelská verze
2023
,Frontiers in Endocrinology
,14
(April)
Diabetic foot is a serious late complication frequently caused by infection and ischaemia. Both require prompt and aggressive treatment to avoid lower limb amputation. The effectiveness of peripheral arterial disease therapy ...
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Impaired renal autoregulation and pressure-natriuresis: any role in the development of heart failure in normotensive and angiotensin II-dependent hypertensive rats?
původní článek
embargo
vydavatelská verze
2023
,Hypertension Research
,46
(9)
The aim of the present study was to assess the autoregulatory capacity of renal blood flow (RBF) and of the pressure-natriuresis characteristics in the early phase of heart failure (HF) in rats, normotensive and with ...
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Posttreatment positivity of BCR::ABL1 in acute lymphoblastic leukemia: Should we keep track?
letter to the editors
embargo
postprint
2023
,American Journal of Hematology
,98
(10)
We read with a great interest the paper focused on different minimal residual disease (MRD) approaches and its significance in Ph+ acute lymphoblastic leukemia (ALL) patients, authored by Short et al. from the MD Anderson ...
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Chimeric JAK2 Kinases Trigger Non-uniform Changes of Cellular Metabolism in BCR-ABL1-like Childhood ALL
letter to the editors
open access
vydavatelská verze
2023
,HemaSphere
,7
(9)
We studied the impact of JAK2 fusions on metabolic rewiring of leukemic cells; we chose two representatives, themost frequent fusion and a novel previously undescribed fusion, and we showed that JAK2 fusions indeed alter ...
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Hybrid Macromolecular Constructs as a Platform for Spectral Nanoprobes for Advanced Cellular Barcoding in Flow Cytometry
původní článek
open access
postprint
2024
,Macromolecular Bioscience
,24
(2)
Herein, an advanced bioconjugation technique to synthesize hybrid polymer-antibody nanoprobes tailored for fluorescent cell barcoding in flow cytometry-based immunophenotyping of leukocytes is applied. A novel approach of ...
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The KMT2A recombinome of acute leukemias in 2023
původní článek
open access
vydavatelská verze
2023
,Leukemia
,37
(5)
Chromosomal rearrangements of the human KMT2A/MLL gene are associated with de novo as well as therapy-induced infant, pediatric, and adult acute leukemias. Here, we present the data obtained from 3401 acute leukemia patients ...
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Effects of Lactiplantibacillus plantarum and Lacticaseibacillus paracasei supplementation on the single-cell fecal parasitome in children with celiac disease autoimmunity: a randomized, double-blind placebo-controlled clinical trial
původní článek
open access
vydavatelská verze
2023
,Parasites & Vectors
,16
(1)
BACKGROUND: Lactiplantibacillus plantarum HEAL9 and Lacticaseibacillus paracasei 8700:2 positively affect the fecal bacteriome in children with celiac disease autoimmunity after 6 months of supplementation. The aim of the ...
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A failure of Fourier transform infrared spectroscopy to type Burkholderia isolates from chronically infected patients with cystic fibrosis
letter to the editors
open access
postprint
2023
,Microbiology spectrum
,11
(6)
We noted high variability of isolates spectra that prevented assigning isolates to known ST. Moreover, the FT-IR failed to reliably determine whether a chronic patient harbored the same Burkholderia strain over the course ...
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Direct 16S/18S rRNA Gene PCR Followed by Sanger Sequencing as a Clinical Diagnostic Tool for Detection of Bacterial and Fungal Infections: a Systematic Review and Meta-Analysis
přehledový článek
open access
vydavatelská verze
2023
,Journal of Clinical Microbiology
,61
(9)
rRNA gene Sanger sequencing is being used for the identification of cultured pathogens. A new diagnostic approach is sequencing of uncultured samples by using the commercial DNA extraction and sequencing platform SepsiTest ...
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Faecal bacteriome and metabolome profiles associated with decreased mucosal inflammatory activity upon anti-TNF therapy in paediatric Crohn's disease
původní článek
open access
vydavatelská verze
2024
,Journal of Crohn's and Colitis
,18
(1)
BACKGROUND AND AIMS: Treatment by anti-TNFα antibodies (anti-TNF) changes the dysbiotic faecal bacteriome in Crohn's disease (CD). However, it is not known whether these changes are due to decreasing mucosal inflammatory ...
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DIPG-like MYB-altered diffuse astrocytoma with durable response to intensive chemotherapy
kazuistika
open access
vydavatelská verze
2023
,Child's Nervous System
,39
(9)
Pontine gliomas represent difficult to treat entity due to the location and heterogeneous biology varying from indolent low-grade gliomas to aggressive diffuse intrinsic pontine glioma (DIPG). Making the correct tumor ...
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Th1/interferon-γ bias in 22q11.2 deletion syndrome is driven by memory T cells and exacerbated by IL-7
původní článek
open access
vydavatelská verze
2023
,Clinical Immunology
,256
(November)
The aim of this study was to investigate the impact of thymic dysplasia on the phenotypic and functional characteristics of T cells in patients with 22q11.2 deletion syndrome, including T-cell phenotype, transcriptional ...
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Variability of fluorescence intensity distribution measured by flow cytometry is influenced by cell size and cell cycle progression
původní článek
open access
vydavatelská verze
2023
,Scientific Reports
,13
(1)
The distribution of fluorescence signals measured with flow cytometry can be influenced by several factors, including qualitative and quantitative properties of the used fluorochromes, optical properties of the detection ...
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Does advanced maternal age explain the longer hospitalisation of mothers after childbirth?
původní článek
open access
vydavatelská verze
2023
,PLoS One
,18
(4)
BACKGROUND: Fertility postponement, which has comprised the most significant reproductive trend in developed countries over the last few decades, involves a number of social, personal and health consequences. The length ...
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Does Advanced Maternal Age Comprise an Independent Risk Factor for Caesarean Section? A Population-Wide Study
původní článek
open access
vydavatelská verze
2023
,International Journal of Environmental Research and Public Health
,20
(1)
The paper aims to investigate the association between the mother's age and the risk of caesarean section when controlling for health factors and selected socio-demographic characteristics. The analysis employs anonymized ...
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The detection of hypoxia markers in non-HPV and HPV-associated head and neck cancers: implications to patient survival
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2023
,Czech Chemical Society Symposium Series
,21
(5)
In the microenvironment of growing solid tumors, oxygen level often decreases and a hypoxic state is induced. This can lead to a worse treatment response and poor patient prognosis. One of the hypoxia-responsive genes ...
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Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukaemia
původní článek
open access
vydavatelská verze
2023
,Nature Communications
,14
(1)
High hyperdiploid acute lymphoblastic leukemia (HeH ALL), one of the most common childhood malignancies, is driven by nonrandom aneuploidy (abnormal chromosome numbers) mainly comprising chromosomal gains. In this study, ...
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Constitutively active Lyn kinase causes a cutaneous small vessel vasculitis and liver fibrosis syndrome
původní článek
open access
vydavatelská verze
2023
,Nature Communications
,14
(1)
Neutrophilic inflammation is a hallmark of many monogenic autoinflammatory diseases; pathomechanisms that regulate extravasation of damaging immune cells into surrounding tissues are poorly understood. Here we identified ...
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Human polyomaviruses in psoriasis patients on biologic treatment
abstrakt v elektronické podobě
open access
postprint
2023
,Neuveden
Biologic therapy poses a higher risk of viral infection for patients, however current knowledge of human polyomavirus infection in psoriasis patients is stilllimited. In this study, we evaluate the prevalence of BK ...
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Minimal residual disease in BCR::ABL1-positive acute lymphoblastic leukemia: different significance in typical ALL and in CML-like disease
původní článek
open access
vydavatelská verze
2022
,Leukemia
,36
(23)
Recently, we defined "CML-like" subtype of BCR::ABL1-positive acute lymphoblastic leukemia (ALL), resembling lymphoid blast crisis of chronic myeloid leukemia (CML). Here we retrospectively analyzed prognostic relevance ...