The detection of hypoxia markers in non-HPV and HPV-associated head and neck cancers: implications to patient survival
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Datum
2023Autor
Šmahelová, Jana
Pokrývková, Barbora
Šťovíčková, Eliška
Vencálek, Ondřej
Šmahel, Michal
Grega, Marek
Klozar, Jan
Tachezy, Ruth
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In the microenvironment of growing solid tumors, oxygen level often decreases and a hypoxic state is induced. This can lead to a worse treatment response and poor patient prognosis. One of the hypoxia-responsive genes is aspartate-β-hydroxylase(ASPH), whose activity promotes the growth, invasiveness, and metastasis of many solid tumors1. Head and neck cancers (HNC) are highly heterogeneous. A proportion of HNC is induced by high-risk human papillomavirus (HPV) infections and is associated with better patient outcomes compared to patients with tumors linked to tobacco and alcohol abuse.Trvalý odkaz
https://hdl.handle.net/20.500.14178/2072Licence
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