| dc.contributor.author | Šmahelová, Jana | |
| dc.contributor.author | Pokrývková, Barbora | |
| dc.contributor.author | Šťovíčková, Eliška | |
| dc.contributor.author | Vencálek, Ondřej | |
| dc.contributor.author | Šmahel, Michal | |
| dc.contributor.author | Grega, Marek | |
| dc.contributor.author | Klozar, Jan | |
| dc.contributor.author | Tachezy, Ruth | |
| dc.contributor.editor | Šímová, Šárka | |
| dc.date.accessioned | 2023-11-07T10:40:36Z | |
| dc.date.available | 2023-11-07T10:40:36Z | |
| dc.date.issued | 2023 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14178/2072 | |
| dc.description.abstract | In the microenvironment of growing solid tumors, oxygen level often decreases and a hypoxic state is induced. This can lead to a worse treatment response and poor patient prognosis. One of the hypoxia-responsive genes is aspartate-β-hydroxylase(ASPH), whose activity promotes the growth, invasiveness, and metastasis of many solid tumors1. Head and neck cancers (HNC) are highly heterogeneous. A proportion of HNC is induced by high-risk human papillomavirus (HPV) infections and is associated with better patient outcomes compared to patients with tumors linked to tobacco and alcohol abuse. | en |
| dc.language.iso | en | |
| dc.relation.url | http://www.ccsss.cz/index.php/ccsss/issue/view/41/ | |
| dc.rights | Tento výsledek je zpřístupněn v režimu gratis open access, tj. pouze pro čtení. V souladu s § 30 zákona č. 121/2000 Sb., autorského zákona, lze plný text z repozitáře také stáhnout, případně vytisknout, ale pouze pro osobní potřebu. | cs |
| dc.rights | The fulltext is published in the repository as read-only, i.e. in gratis open access mode. Repository visitors are entitled to download and print the fulltext published without a licence for their personal use only (in accordance with § 30 of Act No. 121/2000 Coll., the Copyright Act). | en |
| dc.title | The detection of hypoxia markers in non-HPV and HPV-associated head and neck cancers: implications to patient survival | en |
| dcterms.accessRights | openAccess | |
| dc.date.updated | 2023-11-07T10:40:36Z | |
| dc.subject.keyword | tumor | en |
| dc.subject.keyword | hypoxia-responsive | en |
| dc.subject.keyword | aspartate-β-hydroxylase(ASPH) | en |
| dc.subject.keyword | ASPH | en |
| dc.subject.keyword | HPV | en |
| dc.subject.keyword | HIF1A | en |
| dc.subject.keyword | HIF2 | en |
| dc.subject.keyword | VEGFA, GLUT1 | en |
| dc.subject.keyword | P4HA1 | en |
| dc.subject.keyword | CA9 | en |
| dc.subject.keyword | MMP9 | en |
| dc.subject.keyword | MMP13 | en |
| dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM//LX22NPO5103 | |
| dc.date.embargoStartDate | 2023-11-07 | |
| dc.type.obd | 110 | |
| dc.type.version | info:eu-repo/semantics/publishedVersion | |
| dc.identifier.obd | 637719 | |
| dc.subject.rivPrimary | 30000::30200::30204 | |
| dcterms.isPartOf.name | Czech Chemical Society Symposium Series | |
| dcterms.isPartOf.issn | 2336-7202 | |
| dcterms.isPartOf.journalYear | 2023 | |
| dcterms.isPartOf.journalVolume | 21 | |
| dcterms.isPartOf.journalIssue | 5 | |
| uk.faculty.primaryId | 115 | |
| uk.faculty.primaryName | Přírodovědecká fakulta | cs |
| uk.faculty.primaryName | Faculty of Science | en |
| uk.faculty.secondaryId | 108 | |
| uk.faculty.secondaryId | 109 | |
| uk.faculty.secondaryName | 1. lékařská fakulta | cs |
| uk.faculty.secondaryName | First Faculty of Medicine | en |
| uk.faculty.secondaryName | 2. lékařská fakulta | cs |
| uk.faculty.secondaryName | Second Faculty of Medicine | en |
| uk.department.primaryId | 1034 | |
| uk.department.primaryName | Katedra genetiky a mikrobiologie | cs |
| uk.department.primaryName | Department of Genetics and Microbiology | en |
| uk.department.secondaryId | 1705 | |
| uk.department.secondaryId | 1471 | |
| uk.department.secondaryName | Ústav patologie a molekulární medicíny | cs |
| uk.department.secondaryName | Ústav patologie a molekulární medicíny | en |
| uk.department.secondaryName | Klinika otorinolaryngologie a chirurgie hlavy a krku 1. LF UK a FN Motol | cs |
| uk.department.secondaryName | Department of Otorhinolaryngology, Head and Neck Surgery | en |
| uk.event.name | The second annual meeting of the National Institute of Virology and Bacteriology (NIVB Meeting 2023} | |
| dc.description.pageRange | 231-231 | |
| dc.type.obdHierarchyCs | ABSTRAKT::abstrakt::abstrakt v konferenčním sborníku | cs |
| dc.type.obdHierarchyEn | ABSTRACT::abstract::abstract in conference proceedings | en |
| dc.type.obdHierarchyCode | 110::130::462 | en |
| uk.displayTitle | The detection of hypoxia markers in non-HPV and HPV-associated head and neck cancers: implications to patient survival | en |
