3. Faculty of Medicine
Recent Submissions
-
Infekce lidským papilomavirem (HPV) a gravidita
Human papillomavirus (HPV) infection and pregnancy
original article
open access
published version
2024
,Epidemiologie, mikrobiologie, imunologie
,73
(1)
Lidský papilomavirus (HPV) je celosvětově nejběžnější sexuálně přenosnou virovou infekcí, která může vést ke vzniku benigních lézí nebo maligních nádorů. Prevalence HPV infekce je u těhotných žen dvakrát vyšší než u ...
-
Akutní infarkt myokardu a preexistující levostranné chlopenní vady
lecture
open access
published version
2024
-
Emergence of Escherichia coli ST131 carrying carbapenemase genes, European Union/European Economic Area, August 2012 to May 2024
original article
open access
accepted version
2024
,Eurosurveillance
,29
(47)
Analysis of 594 isolates of Escherichia coli sequence type (ST)131 and its single locus variants carrying carbapenemase genes from 17 European Union/European Economic Area countries revealed acquisition of 18 carbapenemase ...
-
The out-of-hospital cardiac arrest in patients with acute myocardial infarction and pre-existing aortic stenosis
poster
open access
published version
2024
-
Prognosis of cardiogenic shock following acute myocardial infarction
lecture
open access
published version
2023
-
Prediktory prognózy pacientu s akutním infarktem myokardu komplikovaným iniciálně kardiogenním šokem
poster
open access
published version
2023
-
Clinical Characteristics and Outcome of Patients With Acute Myocardial Infarction and Pre-Existing Left Heart Valvular Disease
poster
open access
published version
2024
-
Isokalorická KETOgenní dieta ZLEPŠUJE insulinovou senzitivitu U OBÉZNÍCH ŽEN
poster
open access
published version
2023
-
Polymorphisms in transcription factor binding sites and enhancer regions and pancreatic ductal adenocarcinoma risk
original article
open access
published version
2024
,Human Genomics
,18
(February)
Genome-wide association studies (GWAS) are a powerful tool for detecting variants associated with complex traits and can help risk stratification and prevention strategies against pancreatic ductal adenocarcinoma (PDAC). ...
-
Adenotonsillar pathology in mucopolysaccharidoses - lysosomal storage predominates in paracortical CD63+ cells
original article
open access
published version
2024
,Virchows Archiv
,484
(1)
Despite the adenoids are regularly removed in patients with mucopolysaccharidoses (MPS), the underlying tissue and cellular pathologies remain understudied. We characterized an (immuno)histopathologic and ultrastructural ...
-
The Czech National MS Registry (ReMuS): Data trends in multiple sclerosis patients whose first disease-modifying therapies were initiated from 2013 to 2021
original article
open access
published version
2024
,Biomedical Papers
,168
(3)
AIMS: Multiple sclerosis treatment strategies are changing in the Czech Republic. According to data from 2013-2021, the proportion of patients starting high-efficacy disease-modifying therapies is increasing. In this survey, ...
-
Amiodarone but not propafenone impairs bioenergetics and autophagy of human myocardial cells
original article
open access
published version
2023
,Toxicology and Applied Pharmacology
,477
(October)
Cardiac and extra-cardiac side effects of common antiarrhythmic agents might be related to drug-induced mitochondrial dysfunction. Supratherapeutic doses of amiodarone have been shown to impair mitochondria in animal ...
-
Outcomes Of Patients With Myocardial Infarction And Cardiogenic Shock Treated With Culprit Vessel-Only Versus Multivessel Primary PCI
original article
open access
published version
2024
,Hellenic Journal of Cardiology
,76
(MAR-APR)
INTRODUCTION AND OBJECTIVES: Multivessel primary percutaneous coronary intervention (pPCI) is still often used in patients with ST-elevation myocardial infarction (STEMI) and cardiogenic shock (CS). The study aimed to ...
-
High incidence of occult familial SDHD cases amongst Czech patients with head and neck paragangliomas
original article
open access
published version
2023
,Frontiers in Endocrinology
,14
(December)
INTRODUCTION: Head and neck paragangliomas (HNPGLs) are rare neuroendocrine tumors, which are mostly benign in nature. Amongst all genes, Succinate Dehydrogenase Subunit D (SDHD) is the most commonly mutated in familial ...
-
Molecular Screening in Anaplastic Lymphoma Kinase–Positive Anaplastic Large Cell Lymphoma: Anaplastic Lymphoma Kinase Analysis, Next-Generation Sequencing Fusion Gene Detection, and T-Cell Receptor Immunoprofiling
original article
open access
published version
2024
,Modern Pathology
,37
(3)
Anaplastic lymphoma kinase-positive anaplastic large cell lymphoma (ALK+ ALCL) originates from the T-lineage and is marked by rearrangements of the ALK gene. Over ten fusion partners with the ALK gene are known, with the ...
-
Frentizole derivatives with mTOR inhibiting and senomorphic properties
original article
open access
published version
2023
,Biomedicine & Pharmacotherapy
,167
(November)
Frentizole is immunosuppressive drug with low acute toxicity and lifespan-prolonging effect. Recently, frentizole's potential to disrupt toxic amyloid β (Aβ) - Aβ-binding alcohol dehydrogenase (ABAD) interaction in ...
-
Pro-cognitive effects of dual tacrine derivatives acting as cholinesterase inhibitors and NMDA receptor antagonists
original article
open access
published version
2024
,Biomedicine & Pharmacotherapy
,176
(July)
Therapeutic options for Alzheimer's disease are limited. Dual compounds targeting two pathways concurrently may enable enhanced effect. The study focuses on tacrine derivatives inhibiting acetylcholinesterase (AChE) and ...
-
How to invasively assess left ventricular function and its efficiency of work
summarizing article
open access
published version
2024
,Cor et Vasa
,66
(1)
Effective performance of the left ventricle requires the maintenance of a cardiac output as demanded by the systemic circulation without a high hemodynamic cost or pressure and without a high metabolic cost or oxygen demand ...
-
The role of adipogenic capacity and dysfunctional subcutaneous adipose tissue in the inheritance of type 2 diabetes mellitus: cross-sectional study
original article
open access
published version
2024
,Obesity
,32
(3)
OBJECTIVE: This study tested the hypothesis that limited subcutaneous adipose tissue (SAT) expansion represents a primary predisposition to the development of type 2 diabetes mellitus (T2DM), independent of obesity, and ...
-
Utilization of healthcare services in acute myocardial infarction and the risk of out-of-hospital cardiac death
letter to the editors
open access
published version
2024
,Panminerva Medica
,66
(1)
COVID-19 represented a significant challenge to cardiovascular (cV) medicine research, treatment, prevention, and, to a considerable extent, case management. The global pandemic viral infection increased the risk of ...