3. Faculty of Medicine
Recent Submissions
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Frentizole derivatives with mTOR inhibiting and senomorphic properties
original article
open access
published version
2023
,Biomedicine & Pharmacotherapy
,167
(November)
Frentizole is immunosuppressive drug with low acute toxicity and lifespan-prolonging effect. Recently, frentizole's potential to disrupt toxic amyloid β (Aβ) - Aβ-binding alcohol dehydrogenase (ABAD) interaction in ...
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How to invasively assess left ventricular function and its efficiency of work
summarizing article
open access
published version
2024
,Cor et Vasa
,66
(1)
Effective performance of the left ventricle requires the maintenance of a cardiac output as demanded by the systemic circulation without a high hemodynamic cost or pressure and without a high metabolic cost or oxygen demand ...
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The role of adipogenic capacity and dysfunctional subcutaneous adipose tissue in the inheritance of type 2 diabetes mellitus: cross-sectional study
original article
open access
published version
2024
,Obesity
,32
(3)
OBJECTIVE: This study tested the hypothesis that limited subcutaneous adipose tissue (SAT) expansion represents a primary predisposition to the development of type 2 diabetes mellitus (T2DM), independent of obesity, and ...
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Utilization of healthcare services in acute myocardial infarction and the risk of out-of-hospital cardiac death
letter to the editors
open access
published version
2024
,Panminerva Medica
,66
(1)
COVID-19 represented a significant challenge to cardiovascular (cV) medicine research, treatment, prevention, and, to a considerable extent, case management. The global pandemic viral infection increased the risk of ...
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The Czech Home Parenteral Nutrition Registry REDNUP: Comprehensive Analysis of Adult Patients' Data
original article
open access
published version
2024
,Annals of Nutrition & Metabolism
,80
(3)
INTRODUCTION: Home parenteral nutrition (HPN) is the primary treatment modality for patients with chronic intestinal failure, one of the least common organ failures. This article provides a retrospective analysis of the ...
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Targeted DNA sequencing of high-grade serous ovarian carcinoma reveals association of TP53 mutations with platinum resistance when combined with gene expression
original article
open access
published version
2024
,International Journal of Cancer
,155
(1)
High-grade serous ovarian carcinoma (HGSC) is the most common subtype of ovarian cancer and is among the most fatal gynecological malignancies worldwide, due to late diagnosis at advanced stages and frequent therapy ...
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Third-generation taxanes SB-T-121605 and SB-T-121606 are effective in pancreatic ductal adenocarcinoma
original article
open access
published version
2024
,iScience
,27
(2)
Pancreatic cancer is a severe malignancy with increasing incidence and high mortality due to late diagnosis and low sensitivity to treatments. Search for the most appropriate drugs and therapeutic regimens is the most ...
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Nutritional practices and experiences of people on vegan diet with healthcare system: a qualitative study
summarizing article
open access
published version
2023
,Central European Journal of Public Health
,31
(3)
OBJECTIVES: The growing popularity of diets that restrict the consumption of animal-based foods is an important new challenge for the public healthcare system in Czechia. While the environmental and health-related benefits ...
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Atrial fibrillation therapy and stroke prevention in hemodialysis patients
summarizing article
open access
published version
2023
,Kardiologia Polska
,81
(12)
The prevalence of atrial fibrillation (AF) in patients with chronic kidney disease (CKD), especially on hemodialysis (HD) is higher compared to the general population without CKD and reaches ~20%. The risk of ischemic ...
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Microdialysis as a tool for antibiotic assessment in patients with diabetic foot: a review
summarizing article
embargoed access
published version
2023
,Frontiers in Endocrinology
,14
(April)
Diabetic foot is a serious late complication frequently caused by infection and ischaemia. Both require prompt and aggressive treatment to avoid lower limb amputation. The effectiveness of peripheral arterial disease therapy ...
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Impaired renal autoregulation and pressure-natriuresis: any role in the development of heart failure in normotensive and angiotensin II-dependent hypertensive rats?
original article
embargoed access
published version
2023
,Hypertension Research
,46
(9)
The aim of the present study was to assess the autoregulatory capacity of renal blood flow (RBF) and of the pressure-natriuresis characteristics in the early phase of heart failure (HF) in rats, normotensive and with ...
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ABCB1 Amplicon Contains Cyclic AMP Response Element-Driven TRIP6 Gene in Taxane-Resistant MCF-7 Breast Cancer Sublines
original article
open access
published version
2023
,Genes
,14
(2)
A limited number of studies are devoted to regulating TRIP6 expression in cancer. Hence, we aimed to unveil the regulation of TRIP6 expression in MCF-7 breast cancer cells (with high TRIP6 expression) and taxane-resistant ...
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Resynchronization for shifting conduction patterns - When a coronary sinus lead is not enough
casuistics
open access
published version
2023
,Indian Pacing and Electrophysiology Journal
,23
(6)
A 60-year-old patient with heart failure (NYHA II) due to non-ischemic cardiomyopathy with a left ventricular end-diastolic diameter (LVEDD) of 73 mm and left ventricular ejection fraction (LVEF) 20% presented with ...
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Left ventricular septal pacing - can we trust the ECG?
casuistics
open access
published version
2023
,Indian Pacing and Electrophysiology Journal
,23
(6)
In contrast to left bundle branch pacing, the criteria for left ventricular septal pacing (LVSP) were never validated. LVSP is usually defined as deep septal deployment of the pacing lead with a pseudo-right bundle branch ...
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Prediction of post-operative atrial fibrillation in patients after cardiac surgery using heart rate variability
original article
open access
published version
2023
,BMC Cardiovascular Disorders
,23
(June)
PURPOSE: Post-operative atrial fibrillation (PoAF) occurs in ~ 30% of patients after cardiac surgery. The etiology of PoAF is complex, but a disbalance in autonomic systems plays an important role. The goal of this study ...
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Severe COVID-19 associated hyperglycemia is caused by beta cell dysfunction: a prospective cohort study
original article
open access
published version
2023
,Nutrition & Diabetes
,13
(July)
BACKGROUND: COVID-19, an infectious disease caused by SARS-CoV-2, was shown to be associated with an increased risk of new-onset diabetes. Mechanisms contributing to the development of hyperglycemia are still unclear. We ...
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A randomized comparison of His bundle pacing versus right ventricular pacing: Effect on left ventricular function and biomarkers of collagen metabolism
original article
open access
published version
2023
,Kardiologia Polska
,81
(5)
BACKGROUND: Right ventricular pacing (RVP) can result in pacing-induced cardiomyopathy (PICM). It is unknown whether specific biomarkers reflect differences between His bundle pacing (HBP) and RVP and predict a decrease ...
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Nonprocedural bleeding after left atrial appendage closure versus direct oral anticoagulants: A subanalysis of the randomized PRAGUE-17 trial
original article
open access
published version
2023
,Journal of Cardiovascular Electrophysiology
,34
(9)
INTRODUCTION: Observational studies have shown low bleeding rates in patients with atrial fibrillation (AF) treated by left atrial appendage closure (LAAC); however, data from randomized studies are lacking. This study ...
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Prevalence of iodine deficiency among vegan compared to vegetarian and omnivore children in the Czech Republic: cross-sectional study
original article
open access
published version
2023
,European Journal of Clinical Nutrition
,77
(11)
BACKGROUND: The intake and homeostasis of iodine, an essential micronutrient that plays a vital role in thyroid physiology, is of particular concern with the increasing popularity of vegetarian (VG) and vegan (VN) diets. ...
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Acute ischaemic stroke: recent advances in reperfusion treatment
summarizing article
open access
published version
2023
,European Heart Journal
,44
(14)
During the last 5-7 years, tremendous progress was achieved in the reperfusion treatment of acute ischaemic stroke during its first few hours from symptom onset. This review summarizes the latest evidence from randomized ...
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