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Isoprenaline modified the lipidomic profile and reduced β-oxidation in HL-1 cardiomyocytes: In vitro model of takotsubo syndrome
(2022)
Recent studies have suggested a pathogenetic link between impaired mitochondria and Takotsubo syndrome (TTS), which is closely connected with catecholamine overstimulation, poor outcomes, and changes in lipid metabolism. ...
Whole Exome Sequencing of Epithelial Ovarian Carcinomas Differing in Resistance to Platinum Therapy
(2022)
Epithelial ovarian carcinoma (EOC) is highly fatal because of the risk of resistance to therapy and recurrence. We performed whole-exome sequencing of blood and tumor tissue pairs of 50 patients with surgically resected ...
Epidemic spread of KPC-producing bacteria in the Czech Republic
(2022)
Carbapenems are currently last-resort antibiotics for the therapy of infections caused by multidrug-resistant Gram-negative bacteria. Therefore, the resistence to those drugs represents a significant threat of current ...
Type 1 diabetes incidence increased during the COVID-19 pandemic years 2020-2021 in Czechia: results from a large population-based paediatric register
(2022)
OBJECTIVE: To explore type 1 diabetes incidence patterns during the pandemic years 2020 and 2021 in Czechia, to compare them to the trends from previous decade, and to test its association with indicators of containment ...
Theology of Education and Philosophy of Education in Dialogue
(2022)
This is the first editorial of the journal Theology and Philosophy of Education, a journal for theology of education and philosophy of education. The reason for establishing this journal is to create a common platform for ...
AGAL misprocessing-induced ER stress and the unfolded protein response: lysosomal storage-independent mechanism of Fabry disease pathogenesis?
(2022)
This article is a preprint and has not been certified by peer review.
Electrophysiological and computational analysis of Ca(v)3.2 channel variants associated with familial trigeminal neuralgia
(2022)
Trigeminal neuralgia (TN) is a rare form of chronic neuropathic pain characterized by spontaneous or elicited paroxysms of electric shock-like or stabbing pain in a region of the face. While most cases occur in a sporadic ...
T-wave inversions during conduction system pacing: A marker of more physiological ventricular activation
(2022)
Permanent myocardial pacing can preserve adequate heart rates and improve symptoms and mortality in patients with bradycardia. Conventional right ventricular (RV) pacing is far from the optimal treatment since up to 20% ...
Approaches to Measuring the Activity of Major Lipolytic and Lipogenic Enzymes In Vitro and Ex Vivo
(2022)
Since the 1950s, one of the goals of adipose tissue research has been to determine lipolytic and lipogenic activity as the primary metabolic pathways affecting adipocyte health and size and thus representing potential ...
Freedom as an Aim of Education
(2022)
This is the second editorial of the first volume of the journal Theology and Philosophy of Education. The title of this editorial shows what could be seen as a common topic for all of the articles published in this second ...