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STING agonists induce monocyte depletion with characteristics of multiple regulated cell deaths
(2023)
Double-stranded DNA and cyclic dinucleotides activate the cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway, which leads to the production of type I interferons (IFNs) and proinflammatory cytokines ...
STING agonists activate multiple regulated cell death mechanisms in monocytes
(2023)
Stimulation of the innate immune responses using agonist of pattern recognition receptors is one of the investigated therapeutic approaches for treatment of chronic diseases, such as cancer or chronic ...