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MicroRNA signatures in endurance athletes: a review of their potential implications

dc.contributor.authorBaber, Farwa
dc.contributor.authorJaklová Dytrtová, Jana
dc.contributor.authorJakl, Michal
dc.date.accessioned2025-01-30T15:41:10Z
dc.date.available2025-01-30T15:41:10Z
dc.date.issued2024
dc.identifier.urihttps://hdl.handle.net/20.500.14178/2839
dc.description.abstractIntroduction: MicroRNAs (miRNAs) are regulators of post-transcriptional gene expression that reflect individual biological adaptations to environmental exposures. Measuring circulating miRNAs offers a way to evaluate biological changes from behavioural interventions, such as exercise and sports, which relate to adaptation, muscle damage and inflammation. Objectives: This review aims to summarize the current knowledge about circulating miRNAs associated with sports, endurance exercise, training and the identification of cardiovascular, as well as myocyte disorders in humans. It is primarily focused on the role of miRNAs in endurance and aerobic training and their regulation in response to cardiac hypertrophy, myocyte damage, fibrosis and inflammation. Material and methods: In this review, the existing literature on miRNA expression is examined in various exercise contexts, identifying key miRNAs involved in the adaptive response to exercise. Research included in the review primarily employed quasi-experimental designs, focusing on pre-and post-exercise miRNA expression changes in elite athletes and healthy indi-viduals. Results: Key miRNAs, such as miR-1, miR-133, miR-21, miR-155, miR-206, miR-208 and miR-146, are highlighted for their significant roles in exercise adaptation. Two key future research directions are identified in the review: investigating the biological pathways linked to different exercise modalities and understanding miRNA expressions in various exercise contexts. Conclusions: Despite varied findings, the review allows to emphasize the need for future research to explore miRNA-gene interactions and the impact of different training types as well as durations, especially comparing athletes to healthy populations. This will help to better understand the relationship between miRNA expression and exercise performance.en
dc.language.isoen
dc.relation.urlhttps://doi.org/10.5604/01.3001.0054.7756
dc.rightsCreative Commons Uveďte původ-Zachovejte licenci 4.0 Internationalcs
dc.rightsCreative Commons Attribution-ShareAlike 4.0 Internationalen
dc.titleMicroRNA signatures in endurance athletes: a review of their potential implicationsen
dcterms.accessRightsopenAccess
dcterms.licensehttps://creativecommons.org/licenses/by-sa/4.0/legalcode
dc.date.updated2025-01-30T15:41:10Z
dc.subject.keywordaerobic exerciseen
dc.subject.keywordbiomarkersen
dc.subject.keywordmiRNAen
dc.subject.keywordmovement interventionen
dc.subject.keywordsporten
dc.identifier.eissn1896-3250
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/UK/COOP/COOP
dc.date.embargoStartDate2025-01-30
dc.type.obd73
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.5604/01.3001.0054.7756
dc.identifier.eidScopus2-s2.0-85208420932
dc.identifier.obd656048
dc.subject.rivPrimary30000::30300::30306
dcterms.isPartOf.nameRehabilitacja Medyczna
dcterms.isPartOf.issn1427-9622
dcterms.isPartOf.journalYear2024
dcterms.isPartOf.journalVolume28
dcterms.isPartOf.journalIssue2
uk.faculty.primaryId119
uk.faculty.primaryNameFakulta tělesné výchovy a sportucs
uk.faculty.primaryNameFaculty of Physical Education and Sporten
uk.department.primaryId100037560577
uk.department.primaryNameKatedra biomedicínského základu v kinantropologiics
uk.department.primaryNameKatedra biomedicínského základu v kinantropologiien
uk.department.secondaryId119
uk.department.secondaryNameFakulta tělesné výchovy a sportucs
uk.department.secondaryNameFaculty of Physical Education and Sporten
dc.description.pageRange52-68
dc.type.obdHierarchyCsČLÁNEK V ČASOPISU::článek v časopisu::přehledový článekcs
dc.type.obdHierarchyEnJOURNAL ARTICLE::journal article::summarizing articleen
dc.type.obdHierarchyCode73::152::205en
uk.displayTitleMicroRNA signatures in endurance athletes: a review of their potential implicationsen


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