Repozitář publikační činnosti UK: Recent submissions
Now showing items 361-380 of 2148
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Modulating Antimicrobial Efficacy Through Hybrid Compounds: Novel Linkers and Scaffold Switching from Isoniazid to 3,5-Dinitrobenzohydrazide
other article in proceedings
open access
updated version
2025
,Praha
,Book of abstracts of the 12 th International Conference on Chemical Technology
Tuberculosis and non-tuberculous mycobacterial infections present significant treatment challenges due to rising drug resistance. Building on our previous success with (E)-2-(2-isonicotinoylhydrazineylidene)-N-phenylpropanamides,1 ...
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Nové látky a nové přístupy v terapii herpetických virů
other article in proceedings
open access
published version
2025
,Hradec Králové
,SBORNÍK ABSTRAKT XXVII. HRADECKÉ VIROLOGICKÉ DNY Celostátní konference virologů
Infekce způsobené herpetickými viry (HSV-1, HSV-2, VZV, CMV, EBV aj.) stále představujívýznamný zdravotnický problém. Dosavadní terapie je založena zejména na nukleosidových/nukleotidových analozích (acyklovir, ganciklovir ...
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Repurposing sulfonamidů jako antifungálních léčiv aneb Starého psa novým kouskům naučíš
other article in proceedings
open access
published version
2025
,Praha
,SBORNÍK ABSTRAKTŮ Konference 19. a 20. listopadu 2025
Narůstající rezistence mikroorganismů představuje závažnou hrozbu pro veřejné zdraví, což vytváří urgentní potřebu nových léčiv. Systémové mykózy jsou však v porovnání s bakteriálními infekcemi stále přehlíženy, ačkoli ...
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Migrastatic therapy as a potential game-changer in adaptive cancer treatment
original article
open access
accepted version
2026
,Springer Nature
,Scientific Reports
,16
(1)
Adaptive therapy, which anticipates and counters the evolution of resistance in cancer cells, has gained significant traction, especially following the success of the Zhang et al.'s protocol in treating metastatic ...
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Validity and reliability of the Czech adaptation of the Sport Motivation Scale-6
poster
restricted access
draft
2025
This study examined the factorial validity and reliability of the Czech adaptation of the Sport Motivation Scale-6 (SMS-6) in a sample of 303 competitive athletes. Confirmatory factor analysis supported the six-factor ...
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The role of myotubularin-related lipid phosphatases in cancer pathogenesis
summarizing article
open access
published version
2026
,Academic Press
,Experimental and Molecular Pathology
,145
(January)
Myotubularin-related proteins (MTMRs) comprise a family of lipid phosphatases using phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate as their substrate. Several members have a well-established ...
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Structure-Activity Relationships of Novel Pyrimidine Derivatives as potential antimycobacterial Agents
abstract in conference proceedings
open access
published version
2025
,Praha
,Česká společnost chemická
,Czech Chemical Society Symposium Series
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains the leading cause of death from a single infectious agent, exerting severe health and economic burdens, particularly in Sub-Saharan Africa and South-East ...
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Adenosine promotes trophoblast proliferation without inducing differentiation or apoptosis
original article
open access
published version
2025
,Harcourt
,Placenta
,172
(December)
Objective: Adenosine and other nucleosides are essential regulators of cellular processes, but their specific roles in trophoblast growth and regulation remain incompletely defined. This study investigated the effects of ...
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Monitoring the Alternative Pathway of Meropenem Degradation by OXA-48-Type Carbapenemases
abstract in conference proceedings
open access
published version
2025
,Praha
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,23
(4)
Background:Overuse of carbapenems has been associated with an increasing prevalence of resistance, particularly among the Enterobacterales, Pseudomonasspp., and Acinetobacter spp. Resistance is mediated by the ...
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Prenatal paroxetine dysregulates monoamine homeostasis and affects placental hemodynamics in the rat fetoplacental unit
original article
open access
published version
2025
,Elsevier
,Biomedicine & Pharmacotherapy
,192
(November)
Antidepressant use during pregnancy is increasingly common, with selective serotonin reuptake inhibitors (SSRIs) widely prescribed for maternal depression. However, growing evidence links prenatal SSRI exposure to adverse ...
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Integrating Long-Read Nanopore Sequencing for Precision Resolution of Genomic Variants in Dystonia
original article
open access
published version
2026
,John Wiley & Sons
,Movement Disorders
,41
(1)
Background: Although many individuals with dystonia present with features indicative of single-gene etiologies, obtaining definitive genetic diagnoses can be challenging. Objective: We assessed the value of nanopore-based ...
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Quality of Life and Its Associates In Narcolepsy 1 and 2 Types and Idiopathic Hypersomnia
original article
open access
published version
2025
,Sleep Medicine
,129
(May)
Objective and background: Health-related quality of life (HRQoL) is reduced in narcolepsy type 1 (NT1), but proper information on HRQoL in narcolepsy type 2 (NT2) and idiopathic hypersomnia (IH) is lacking. This study ...
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Atlas-Guided Tractography for Segmentation of Striatal Subregions in Early Parkinson’s Disease
article in reviewed proceedings
open access
published version
2025
,EDP Sciences
,Bio Web of Conferences
,195
Parkinson's disease (PD) and isolated REM sleep behaviour disorder (iRBD) are neurodegenerative conditions associated with alterations in the striatum, a subcortical structure essential for motor and cognitive functions. ...
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Blood and cerebrospinal fluid metallomics uncover mercury, chromium, and iron alterations in de novo Parkinson's disease
original article
open access
published version
2025
,IOS Press
,Journal of Parkinson's Disease
,15
(8)
Background: Given the increasing global prevalence of Parkinson's disease (PD) and its complex etiopathogenesis, understanding the role of environmental factors is crucial. Prior investigations suggested a potential link ...
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De Novo Variants in PPFIA2 in Individuals With Neurodevelopmental Disorders
casuistics
open access
published version
2026
,Wiley-Liss
,American Journal of Medical Genetics: Part A
,200
(2)
Liprin-alpha 2, encoded by PPFIA2, belongs to the family of Liprin-alpha proteins which constitute major synaptic scaffolds participating in the assembly and maturation of synapses. Heterozygous de novo variants in PPFIA2 ...
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Novel structure motif for the selective inhibition of TET1 protein based on perimidines
original article
open access
published version
2026
,Elsevier B.V.
,Journal of Molecular Structure
,1349
(January)
The targeting of epigenetic factors, particularly TET proteins (ten-eleven translocation methylcytosine dioxygenases), has emerged as a significant focus in medicinal and biological research. Recent findings indicate that ...
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Low-Intensity Constant Light During Early Postnatal Development Induces Sex-Specific Anxiety-Like Behaviour and Region- and Sex-Specific Changes in Circadian Gene Expression and RNA Editing
original article
open access
accepted version
2026
,Kluwer
,Cellular and Molecular Neurobiology
,46
(1)
Early-life exposure to light at night can disrupt the maturation of the circadian system and lead to long-lasting behavioural and molecular alterations. We exposed rat pups to constant light (LL; 16 lx) from birth (P0) to ...
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Role a postavení interkulturních pracovníků v poskytování zdravotní péče uprchlíkům a migrantům v Česku
The role and position of intercultural workers in the provision of health care to refugees and migrants in the Czech Republic
original article
open access
published version
2025
,Časopis lékařů českých
,164
(1)
Interkulturní pracovníci (též interkulturní mediátoři, komunitní tlumočníci) hrají klíčovou roli v překonávání jazykových a kulturních bariér mezi migranty a zdravotnickými systémy hostitelských zemí. Světová zdravotnická ...
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Dysregulated mitochondrial homeostasis and DNA repair in the progression from colon adenoma to cancer
original article
open access
published version
2025
,North Shore-Long Island Jewish Research Institute
,Molecular Medicine
,31
(November)
BACKGROUND: While nuclear DNA (nDNA) damage and alterations in nDNA repair are known to play a role in colon cancer (CC), there is insufficient research investigating these processes in mitochondrial DNA (mtDNA). METHODS: ...
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Monotheism of the Divine Names and Attributes as a Defining Criterion of Salafism
original article
open access
published version
2025
,Brill
,Die Welt des Islams
,Neuveden
(2025)
This study examines how Saudi Salafism, as a modern ideological construct, hasgradually linked the theological teachings about the monotheism of the Divine namesand attributes (tawḥīd al-asmāʾ wa-l-ṣifāt) of the Ḥanbalī ...
