Repozitář publikační činnosti UK: Recent submissions
Now showing items 701-720 of 1842
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Microtubule-associated NAV3 regulates invasive phenotypes in glioblastoma cells
original article
open access
published version
2025
,Brain Pathology
,35
(1)
Glioblastomas are aggressive brain tumors for which effective therapy is still lacking, resulting in dismal survival rates. These tumors display significant phenotypic plasticity, harboring diverse cell populations ranging ...
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Circulating perturbation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) is associated to cardiac remodeling and NLRP3 inflammasome in cardiovascular patients with insulin resistance risk
original article
open access
published version
2024
,Academic Press
,Experimental and Molecular Pathology
,137
(June)
Lipidome perturbation occurring during meta -inflammation is associated to left ventricle (LV) remodeling though the activation of the NLRP3 inflammasome, a key regulator of chronic inflammation in obesity -related disorders. ...
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Electrical remodeling of atrioventricular junction: a study on retrogradely perfused chick embryonic heart
original article
open access
published version
2024
,American Physiological Society
,American Journal of Physiology - Heart and Circulatory Physiology
,327
(3)
Atrioventricular (AV) accessory pathways (APs) provide additional electrical connections between the atria and ventricles, resulting in severe electrical disturbances. It is generally accepted that APs originate in the ...
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Incorporating high-resolution climate, remote sensing and topographic data to map annual forest growth in central and eastern Europe
original article
open access
published version
2024
,Science of the Total Environment
,913
(February)
To enhance our understanding of forest carbon sequestration, climate change mitigation and drought impact on forest ecosystems, the availability of high-resolution annual forest growth maps based on tree-ring width (TRW) ...
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Expanding clinical spectrum of PAICS deficiency: Comprehensive analysis of two sibling cases
original article
open access
published version
2025
,Nature Publishing Group
,European Journal of Human Genetics
,33
(7)
De novo synthesis of purines (DNPS) is a biochemical pathway that provides the purine bases for synthesis of essential biomolecules such as nucleic acids, energy transfer molecules, signaling molecules and various cofactors. ...
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Local diversity of soil forming processes in the semi-arid tropics and its environmental drivers: An example from Otavi Mountains, northern Namibia
original article
open access
published version
2025
,Catena
,249
(February)
Local diversity of soil units and properties in a semi-arid tropical climate is controlled by a number of interacting factors, whose contribution to the final form of individual soil characteristics is often difficult to ...
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Clinical Features, Outcomes, and Response to Corticosteroid Treatment of Acute Tubulointerstitial Nephritis: A Single-Centre Retrospective Cohort Study in the Czech Republic
original article
open access
published version
2024
,S. Karger
,Kidney & Blood Pressure Research
,49
(1)
Introduction: Acute tubulointerstitial nephritis (ATIN) is a well-recognized cause of acute kidney injury (AKI) due to the tubulointerstitial inflammation. The aim of this study was to explore the clinical features, outcomes, ...
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Arsenic bioaccessibility in environmentally important arsenic minerals
original article
open access
published version
2025
,Journal of Hazardous Materials
,485
(March)
The potential risk to humans from incidental ingestion of As-contaminated soil and mine waste is influenced by the mineralogical composition of the As phases present. Using the Solubility Bioaccessibility Research Consortium ...
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Health Problems of Civilization Physical activity: diseases and issues recognized by the WHO
original article
open access
published version
2024
,Health Problems of Civilization
,18
(2)
Background. The aim of the work was to ascertain the differences in the temporal characteristics of the gait cycle of slow walking in high heels. The study particularly focusedon a group of women who started to wear high ...
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Metabolism of primary high-grade serous ovarian carcinoma (HGSOC) cells under limited glutamine or glucose availability
original article
open access
published version
2024
,Cancer & Metabolism
,12
(September)
BackgroundHigh-grade serous ovarian carcinoma (HGSOC) is the most common and aggressive subtype of epithelial ovarian carcinoma. It is primarily diagnosed at stage III or IV when the 5-year survival rate ranges between 20% ...
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Compensatory exercises for young cyclists in the pubescents
original article
open access
published version
2024
,Physical Activity Review
,12
(1)
The aim of the study was to evaluate the state of the musculoskeletal system of selectedcyclists and to propose appropriate compensatory exercises, the effects of which were verified inpractice. Twenty-eight MTB cyclists ...
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Revising pathogenesis of AP1S1-related MEDNIK syndrome: a missense variant in the AP1S1 gene as a causal genetic lesion
original article
open access
published version
2024
,Journal of Molecular Medicine
,102
(11)
MEDNIK syndrome is a rare autosomal recessive disease characterized by mental retardation, enteropathy, deafness, peripheral neuropathy, ichthyosis, and keratoderma, and caused by variants in the adaptor-related protein ...
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Distinct pattern of genomic breakpoints in CML and BCR::ABL1-positive ALL: analysis of 971 patients
original article
open access
published version
2024
,Molecular Cancer
,23
(1)
BACKGROUND: The BCR::ABL1 is a hallmark of chronic myeloid leukemia (CML) and is also found in acute lymphoblastic leukemia (ALL). Most genomic breaks on the BCR side occur in two regions - Major and minor - leading to ...
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Rewired glutamate metabolism diminishes cytostatic action of L-asparaginase
original article
open access
published version
2024
,Elsevier Science
,Cancer Letters
,605
(November)
Tumor cells often adapt to amino acid deprivation through metabolic rewiring, compensating for the loss with alternative amino acids/substrates. We have described such a scenario in leukemic cells treated with L-asparaginase ...
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Mouse polyomavirus infection induces lamin reorganisation
original article
open access
published version
2024
,FEBS Journal
,291
(23)
The nuclear lamina is a dense network of intermediate filaments beneath the inner nuclear membrane. Composed of A-type lamins (lamin A/C) and B-type lamins (lamins B1 and B2), the nuclear lamina provides a scaffold for the ...
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Italian peninsula as a hybridization zone of Ixodes inopinatus and I. ricinus and the prevalence of tick-borne pathogens in I. inopinatus, I. ricinus, and their hybrids
original article
open access
published version
2024
,Parasites & Vectors
,17
(1)
BACKGROUND: Ixodes inopinatus was described from Spain on the basis of morphology and partial sequencing of 16S ribosomal DNA. However, several studies suggested that morphological differences between I. inopinatus and ...
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Toscana virus – finding the new vectors
abstract in conference proceedings
open access
published version
2024
,New Orleans
,American Society of Tropical Medicine and Hygiene (ASTMH)
,ASTMH Abstract Book 2024
,2024
Arbovirus Phlebovirus toscanaense (TOSV) is an emerging but still neglected human pathogen that circulates in countries around the Mediterranean Sea. The manifestation of the disease varies from non-symptomatic forms through ...
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Religious-secular as non-competitive: Encouraging participative church in a Czech Catholic diocese
original article
embargoed access
published version
2024
,Social Compass
,71
(2)
The presented text builds upon 4 years of applied research intended to support the transformation of a Czech Catholic diocese into a more participative organisation, internally and externally. This process allowed us to ...
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Understanding users’ responses to disclosed vs. undisclosed customer service chatbots: a mixed methods study
original article
embargoed access
published version
2024
,AI & Society
,39
(6)
Due to huge advancements in natural language processing (NLP) and machine learning, chatbots are gaining significance in the field of customer service. For users, it may be hard to distinguish whether they are communicating ...
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Mouse PML protein isoforms and their role in innate antiviral immunity
abstract in e-form
open access
accepted version
2024
Promyelocytic leukaemia nuclear bodies (PML NBs) are dynamic, multiprotein, membrane-less structures composed of the main scaffold PML protein and various stable or transient partner proteins. Beyond their diverse endogenous ...



















