Repozitář publikační činnosti UK: Recent submissions
Now showing items 741-760 of 939
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Metabolites of De Novo Purine Synthesis: Metabolic Regulators and Cytotoxic Compounds
original article
open access
published version
2022
,Metabolites [online]
,12
(12)
Cytotoxicity of de novo purine synthesis (DNPS) metabolites is critical to the pathogenesis of three known and one putative autosomal recessive disorder affecting DNPS. These rare disorders are caused by biallelic mutations ...
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Skin inflammation and impaired adipogenesis in a mouse model of acid ceramidase deficiency
original article
open access
published version
2022
,Journal of Inherited Metabolic Disease
,45
(6)
Acid ceramidase catalyzes the degradation of ceramide into sphingosine and a free fatty acid. Acid ceramidase deficiency results in lipid accumulation in many tissues and leads to the development of Farber disease (FD). ...
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Restoration of functional network state towards more physiological condition as the correlate of clinical effects of pallidal deep brain stimulation in dystonia
original article
open access
published version
2022
,Brain Stimulation
,15
(5)
Background: Deep brain stimulation of the internal globus pallidus (GPi DBS) is an invasive therapeutic modality intended to retune abnormal central nervous system patterns and relieve the patient of dys-tonic or other ...
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Sex bias in multiple sclerosis and neuromyelitis optica spectrum disorders: How it influences clinical course, MRI parameters and prognosis
summarizing article
open access
published version
2022
,Frontiers in Immunology
,13
(August)
This review is a condensed summary of representative articles addressing the sex/gender bias in multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD). The strong effects of sex on the incidence and ...
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Brainstem lesions are associated with diffuse spinal cord involvement in early multiple sclerosis
original article
open access
published version
2022
,BMC Neurology
,22
(1)
Background: Early infratentorial and focal spinal cord lesions on magnetic resonance imaging (MRI) are associated with a higher risk of long-term disability in patients with multiple sclerosis (MS). The role of diffuse ...
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Azulene hydrazide-hydrazones for selective targeting of pancreatic cancer cells
original article
open access
published version
2022
,Biomedicine & Pharmacotherapy
,155
(November)
Dysregulation of iron homeostasis is one of the important processes in the development of many oncological diseases, such as pancreatic cancer. Targeting it with specific agents, such as an iron chelator, are promising ...
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Ráz ve španělštině, italštině a portugalštině českých mluvčích
The Glottal Stop in Czech Learners’ Spanish, Italian and Portuguese
original article
restricted access
published version
2022
,Časopis pro moderní filologii
,104
(2)
Tato studie analyzuje, do jaké míry čeští mluvčí studující španělštinu, italštinu a portugalštinu používají ve svých cílových jazycích ráz, nebo vázání, a porovnává je s rodilými mluvčími. V článku jsou diskutovány také ...
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Dynamické formy a žánry: reprezentace genderu v populární kultuře
Dynamic forms and genres: representations of gender in popular culture
editorial
open access
published version
2022
,Gender a Výzkum
,23
(1)
Editorial ke speciálnímu monotematickému číslu časopisu Gender a výzkum.
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Approaches to Measuring the Activity of Major Lipolytic and Lipogenic Enzymes In Vitro and Ex Vivo
original article
embargoed access
published version
2022
,International Journal of Molecular Sciences [online]
,23
(19)
Since the 1950s, one of the goals of adipose tissue research has been to determine lipolytic and lipogenic activity as the primary metabolic pathways affecting adipocyte health and size and thus representing potential ...
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T-wave inversions during conduction system pacing: A marker of more physiological ventricular activation
editorial
embargoed access
published version
2022
,Kardiologia Polska
,80
(10)
Permanent myocardial pacing can preserve adequate heart rates and improve symptoms and mortality in patients with bradycardia. Conventional right ventricular (RV) pacing is far from the optimal treatment since up to 20% ...
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Isoprenaline modified the lipidomic profile and reduced β-oxidation in HL-1 cardiomyocytes: In vitro model of takotsubo syndrome
original article
embargoed access
published version
2022
,Frontiers in Cardiovascular Medicine [online]
,9
(August)
Recent studies have suggested a pathogenetic link between impaired mitochondria and Takotsubo syndrome (TTS), which is closely connected with catecholamine overstimulation, poor outcomes, and changes in lipid metabolism. ...
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Konceptualizace Evropské unie v českém politickém diskurzu
Conceptualization of the European Union in the Czech political discourse
original article
open access
published version
2022
,Nová Čeština doma & ve světě
,2022
(2)
Článek se zabývá konceptuálními metaforami spojenými s prezentací Evropské unie v českém politickém diskurzu. Politický diskurz je součástí komplexního vztahu mezi politikem a společností a je zaměřen na utváření politické ...
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"To já jsem matkou svého otce" : ženský princip a staroegyptské náboženské prvky v gnósi
"'Tis I, Mother of my Father" : The Feminine Principle and Ancient Egyptian Religious Motifs in Gnosticism
original article
open access
published version
2020
,Religio
,28
(1)
Jak pregnantně formuloval G. Fowden ve vztahu ke zkoumání "staroegyptských" kořenů hermetické tradice, gnósi je potřeba vnímat jako součást velice synkretického prostředí pozdní antiky, v níž zcela zásadní úlohu hrál Egypt. ...
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Oral presentation of paraneoplastic pemphigus as the first sign of tonsillar HPV associated squamous cell carcinoma. A case report
casuistics
open access
published version
2022
,Biomedical Papers
,166
(4)
Background: Paraneoplastic pemphigus (PNP) in the oral cavity is a rare variant of blistering pemphigus disease closely associated with mostly malignant tumors. The diagnosis may even precede an underlying malignancy ...
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The Influence of Sediments, Lithosphere and Upper Mantle (Anelastic) With Lateral Heterogeneity on Ocean Tide Loading and Ocean Tide Dynamics
original article
open access
published version
2022
,Journal of Geophysical Research: Solid Earth
,127
(11)
Ocean tide loading (OTL) and ocean tide dynamics (OTD) are known to be affected by Earth's internal structures, with the latter being affected by the self-attraction and loading (SAL) potential. Combining the 3D earth ...
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Bridging time scales of faulting: From coseismic to postseismic slip of the M-w 6.0 2014 South Napa, California earthquake
original article
open access
published version
2022
,Science advances [online]
,8
(38)
Transient fault slip spans time scales from tens of seconds of earthquake rupture to years of aseismic afterslip. So far, seismic and geodetic recordings of these two phenomena have primarily been studied separately and ...
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Residence time of inertial particles in 3D thermal convection: Implications for magma reservoirs
original article
embargoed access
accepted version
2022
,Earth and Planetary Science Letters
,591
(May)
The dynamic behaviour of crystals in convecting fluids determines how magma bodies solidify. In particular, it is often important to estimate how long crystals stay in suspension in the host liquid before being deposited ...
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Inferring Io's interior from tidal monitoring
original article
embargoed access
accepted version
2022
,Icarus
,373
(January)
Io's spectacular volcanic activity involves strong tidal dissipation in its interior. Magnetic induction measurements and surface observations of the volcanic activity indicate the presence of significant melt in the ...
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An electric circuit model of the Earth's polar electrojets and field-aligned currents for the estimation of magnetospheric magnetic field from along-track Swarm magnetic data
original article
open access
published version
2022
,Earth, Planets and Space
,74
(1)
This study deals with the analysis of Swarm vector magnetic data in order to create a circuit model of electric currents flowing in the Earth's polar ionosphere and the inner magnetosphere. The model is composed of a system ...
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Empirical Evidence of Frequency-Dependent Directivity Effects From Small-To-Moderate Normal Fault Earthquakes in Central Italy
original article
open access
published version
2022
,Journal of Geophysical Research: Solid Earth
,127
(6)
Rupture directivity and its potential frequency dependence is an open issue within the seismological community, especially for small-to-moderate events. Here, we provide a statistical overview based on empirical evidence ...