Zobrazují se záznamy 761-780 z 1813

    • Polymorphisms in transcription factor binding sites and enhancer regions and pancreatic ductal adenocarcinoma risk 

      původní článek

      open access

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Ünal, Pelin

      ;

      Lu, Ye

      ;

      Bueno-de-Mesquita, Bas

      ;

      van Eijck, Casper H. J.

      ;

      Talar-Wojnarowska, Renata

      ;

      Szentesi, Andrea

      ;

      Gazouli, Maria

      ;

      Kreivenaite, Edita

      ;

      Tavano, Francesca

      ;

      Małecka-Wojciesko, Ewa

      ;

      Erőss, Bálint

      ;

      Oliverius, Martin

      ;

      Bunduc, Stefania

      ;

      Nóbrega Aoki, Mateus

      ;

      Vodičková, Ludmila

      ;

      Boggi, Ugo

      ;

      Giaccherini, Matteo

      ;

      Kondrackiene, Jurate

      ;

      Chammas, Roger

      ;

      Palmieri, Orazio

      ;

      Theodoropoulos, George E.

      ;

      Bijlsma, Maarten F.

      ;

      Basso, Daniela

      ;

      Mohelníková-Duchoňová, Beatrice

      ;

      Souček, Pavel

      ;

      Izbicki, Jakob R

      ;

      Kiudelis, Vytautas

      ;

      Vanella, Giuseppe

      ;

      Arcidiacono, Paolo Giorgio

      ;

      Włodarczyk, Barbara

      ;

      Hackert, Thilo

      ;

      Schöttker, Ben

      ;

      Uzunoglu, Faik G.

      ;

      Bambi, Franco

      ;

      Goetz, Mara

      ;

      Hlaváč, Viktor

      ;

      Brenner, Hermann

      ;

      Perri, Francesco

      ;

      Carrara, Silvia

      ;

      Landi, Stefano

      ;

      Hegyi, Péter

      ;

      Dijk, Frederike

      ;

      Maiello, Evaristo

      ;

      Capretti, Giovanni

      ;

      Testoni, Sabrina Gloria Giulia

      ;

      Petrone, Maria Chiara

      ;

      Stocker, Hannah

      ;

      Ermini, Stefano

      ;

      Archibugi, Livia

      ;

      Gentiluomo, Manuel

      ;

      Cavestro, Giulia Martina

      ;

      Pezzilli, Raffaele

      ;

      Di Franco, Gregorio

      ;

      Milanetto, Anna Caterina

      ;

      Sperti, Cosimo

      ;

      Neoptolemos, John P.

      ;

      Morelli, Luca

      ;

      Vokáčová, Klára

      ;

      Pasquali, Claudio

      ;

      Lawlor, Rita T

      ;

      Bazzocchi, Francesca

      ;

      Kupcinskas, Juozas

      ;

      Capurso, Gabriele

      ;

      Campa, Daniele

      ;

      Canzian, Federico

      2024

      ,

      Henry Stewart Publications

      ,

      Human Genomics

      ,

      18

      (February)

      Genome-wide association studies (GWAS) are a powerful tool for detecting variants associated with complex traits and can help risk stratification and prevention strategies against pancreatic ductal adenocarcinoma (PDAC). ...

    • Haplotype analysis identifies functional elements in monoclonal gammopathy of unknown significance 

      původní článek

      open access

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Thomsen, Hauke

      ;

      Chattopadhyay, Subhayan

      ;

      Weinhold, Niels

      ;

      Vodička, Pavel

      ;

      Vodičková, Ludmila

      ;

      Hoffmann, Per

      ;

      Nöthen, Markus M

      ;

      Jöckel, Karl-Heinz

      ;

      Schmidt, Börge

      ;

      Hajek, Roman

      ;

      Hallmans, Göran

      ;

      Pettersson-Kymmer, Ulrika

      ;

      Späth, Florentin

      ;

      Goldschmidt, Hartmut

      ;

      Hemminki, Kari Jussi

      ;

      Försti, Asta

      2024

      ,

      Nature Publishing

      ,

      Blood Cancer Journal

      ,

      14

      (1)

      Genome-wide association studies (GWASs) based on common single nucleotide polymorphisms (SNPs) have identified several loci associated with the risk of monoclonal gammopathy of unknown significance (MGUS), a precursor ...

    • Survival improvements in esophageal and gastric cancers in the Nordic countries favor younger patients 

      původní článek

      open access

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Hemminki, Kari Jussi

      ;

      Zitrický, František

      ;

      Foersti, Asta

      ;

      Hemminki, Otto

      ;

      Liška, Václav

      ;

      Hemminki, Akseli

      2024

      ,

      WILEY

      ,

      Cancer Medicine

      ,

      13

      (15)

      Esophageal cancer (EC) and gastric cancer (GC) are fatal cancers with a relatively late age of onset. Age is a negative risk factor for survival in many cancers and our aim was to analyze age-specific survival in EC and ...

    • Survival in oral and pharyngeal cancers is catching up with laryngeal cancer in the NORDIC countries through a half century 

      původní článek

      open access

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Zitrický, František

      ;

      Koskinen, Anni I.

      ;

      Hemminki, Otto

      ;

      Försti, Asta

      ;

      Hemminki, Akseli

      ;

      Hemminki, Kari Jussi

      2024

      ,

      Cancer Medicine

      ,

      13

      (1)

      Background: Cancers of the head and neck (HN) are heterogeneous tumors with incidence rates varying globally. In Northern Europe oral and oropharyngeal cancers are the most common individual types. Survival for HN varies ...

    • Survival in Elderly Ovarian Cancer Remains Challenging in the Nordic Countries 

      původní článek

      open access

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Hemminki, Kari Jussi

      ;

      Zitrický, František

      ;

      Försti, Asta

      ;

      Hemminki, Akseli

      2024

      ,

      Cancers

      ,

      16

      (12)

      BACKGROUND: Despite treatment having improved through intensive surgical procedures and chemotherapy-and more recently, targeted therapies-ovarian cancer is the most fatal female cancer. As such, we wanted to analyze ...

    • Does virtual reality allow for a reliable assessment of reaction speed in mixed martial arts athletes? 

      původní článek

      open access

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Creative Commons NC Icon

      Creative Commons NC Icon

      Polechonski, Jacek

      ;

      Langer, Alan

      ;

      Šťastný, Petr

      ;

      Zak, Marcin

      ;

      Zajac-Gawlak, Izabela

      ;

      Maszczyk, Adam

      2024

      ,

      Baltic Journal of Health and Physical Activity

      ,

      16

      (3)

      Introduction: The immersive virtual reality (VR) might bring a new reliable approach to diagnosing motor abilities. Therefore, the main goal of this research was to check the intertrial reliability and diagnostic possibility ...

    • Learnability of state spaces of physical systems is undecidable 

      původní článek

      embargo

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Špelda, Petr

      ;

      Střítecký, Vít

      2024

      ,

      Journal of Computational Science

      ,

      83

      (December 2024)

      Despite an increasing role of machine learning in science, there is a lack of results on limits of empirical exploration aided by machine learning. In this paper, we construct one such limit by proving undecidability of ...

    • Secukinumab Causing Medication-Related Osteonecrosis of the Jaw, in a Patient Diagnosed with Psoriasis and Rheumatoid Arthritis 

      kazuistika

      open access

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Creative Commons NC Icon

      Hauer, Lukáš

      ;

      Moztarzadeh, Omid

      ;

      Baghalipour, Nasimeh

      ;

      Genčur, Jiří

      2024

      ,

      Psoriasis

      ,

      14

      (23 September 2024)

      The use of antiangiogenic and antiresorptive medications, particularly in patients with cancer or osteoporosis, can lead to osteonecrosis of the jaw following tooth extraction, trauma or arising spontaneously- A condition ...

    • Genetic And Environmental Associations Of Nonspecific Chromosomal Aberrations 

      přehledový článek

      open access

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Creative Commons NC Icon

      Hemminki, Kari Jussi

      ;

      Niazi, Yasmeen

      ;

      Vodičková, Ludmila

      ;

      Vodička, Pavel

      ;

      Försti, Asta

      2025

      ,

      Mutagenesis

      ,

      40

      (1)

      Nonspecific structural chromosomal aberrations (CAs) are found in around 1% of circulating lymphocytes from healthy individuals but the frequency may be higher after exposure to carcinogenic chemicals or radiation. CAs ...

    • Social Mobility of Elites in East-Central Europe in Historical Perspective 

      kapitola v kolektivní monografii

      open access

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Creative Commons NC Icon

      Creative Commons NC Icon

      Popovici, Vlad

      ;

      Velková, Alice

      ;

      Klečacký, Martin

      2024

      ,

      Oldenbourg

      ,

      Walter de Gruyter GmbH

      ,

      Climbing up the Social Ladder? Social Mobility of Elites in East-Central Europe in the Long 19th Century

      The chapter discusses the concept of the social mobility and illustrates how historians of modern-time elites in Central and Eastern Europe coneptualize and approach social mobility in conjunction with the more conventional ...

    • Climbing up the Social Ladder? Social Mobility of Elites in East-Central Europe in the Long 19th Century 

      monografie

      open access

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Creative Commons NC Icon

      Creative Commons NC Icon

      Popovici, Vlad

      ;

      Velková, Alice

      ;

      Klečacký, Martin

      2024

      ,

      Oldenbourg

      ,

      Walter de Gruyter GmbH

      Social mobility is about climbing the societal ladder, or switching to a better, more promising or rewarding position. But how does this work for those already atop or very close to it? The studies in the book explore ...

    • Medium-run effects of COVID-19 induced distant learning on students’ academic performance 

      původní článek

      open access

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Pertold-Gebicka, Barbara

      2024

      ,

      Labour Economics

      ,

      Neuveden

      (89)

      Administrative data on bachelor students for 2014/15 to 2022/23 academic years are used to analyze their performance before, during, and - what is new in the literature - after the COVID-19 pandemic. The analysis reveals ...

    • COVID angels fighting daily demons? Mental well-being of healthcare workers and religiosity 

      původní článek

      open access

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Barili, Emilia

      ;

      Bertoli, Paola

      ;

      Grembi, Veronica

      ;

      Rattini, Veronica

      2024

      ,

      European Economic Review

      ,

      162

      (February 2024)

      Relying on a unique survey of more than 15,000 healthcare workers conducted from June to August 2020 in Italy, we show that religious priming caused participants to have a less dramatic recollection of their distressful ...

    • Enhancing the Antimycobacterial Efficacy of Pyridine-4-Carbohydrazide: Linkage to Additional Antimicrobial Agents via Oxocarboxylic Acids 

      původní článek

      open access

      postprint

      Creative Commons License Icon

      Creative Commons BY Icon

      Pflégr, Václav

      ;

      Konečná, Klára

      ;

      Stolaříková, Jiřina

      ;

      Österreicher, Jan

      ;

      Janďourek, Ondřej

      ;

      Krátký, Martin

      2025

      ,

      Royal Society of Chemistry

      ,

      RSC Medicinal Chemistry

      ,

      16

      (2)

      This study evaluates the antimycobacterial potential of novel "mutual" bioactive amides, combining pyridine-4-carbohydrazide (isoniazid, INH) with various antimicrobial agents (sulphonamides, 4-aminosalicylic acid, ...

    • Metabolic dysfunction-associated steatotic liver disease-induced changes in the antioxidant system: a review 

      přehledový článek

      open access

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Svobodová, Gabriela

      ;

      Horní, Martin

      ;

      Velecká, Eva

      ;

      Boušová, Iva

      2025

      ,

      Archives of Toxicology

      ,

      99

      (January)

      Metabolic dysfunction-associated steatotic liver disease (MASLD) is a heterogeneous condition characterized by liver steatosis, inflammation, consequent fibrosis, and cirrhosis. Chronic impairment of lipid metabolism is ...

    • Uncovering Relationships using Bayesian Networks: A Case Study on Conspiracy Theories 

      příspěvek v recenzovaném konferenčním sborníku

      open access

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Vomlel, Jiří

      ;

      Kuběna, Aleš

      ;

      Šmíd, Martin

      ;

      Weinerová, Josefína

      2024

      ,

      Nijmegen

      ,

      Proceedings of Machine Learning Research

      ,

      Probabilistic Graphical Models

      ,

      246

      Bayesian networks (BNs) represent a probabilistic model that can visualize relationships between variables. We apply various BN structure learning algorithms to a large dataset from a Czech university entrance exam. This ...

    • Monocyte cell death induced by sting agonists combines apoptosis, pyroptosis and caspase 8 activation 

      abstrakt v elektronické podobě

      open access

      postprint

      Creative Commons License Icon

      Creative Commons BY Icon

      Pimková Polidarová, Markéta

      ;

      Brázdová, Andrea

      ;

      Plecitá, Lydie

      ;

      Hirsch, Ivan

      ;

      Grantz Šašková, Klára

      2024

      ,

      Česká společnost chemická

      ,

      Czech Chemical Society Symposium Series

      ,

      22

      (6)

      The cyclic GMP GMP-AMP synthase - stimulator of interferon genes (cGAS cGAS-STING) pathway recognizes double double-stranded DNA in cytoplasm. Activation of the pathway induces secretion of proinflammatory cytokines and ...

    • Do kindergartens mitigate or exacerbate socioeconomic inequalities in language exposure? The case of home-based and kindergarten-based shared book reading activities in China 

      původní článek

      open access

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Cui, Shujing

      ;

      Greger, David

      2024

      ,

      Humanities & social sciences communications

      ,

      11

      (1)

      Shared book reading is a well-established practice for boosting children's language exposure and enhancing early development at home and in child care settings. The present study examined the socioeconomic gaps in home-based ...

    • FosA3 emerging in clinical carbapenemase-producing C. freundii 

      původní článek

      open access

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Marchetti, Vittoria Mattioni

      ;

      Venturelli, Irene

      ;

      Cassetti, Tiziana

      ;

      Meschiari, Marianna

      ;

      Migliavacca, Roberta

      ;

      Bitar, Ibrahim

      2024

      ,

      Frontiers in Cellular and Infection Microbiology

      ,

      14

      (06 August 2024)

      Fosfomycin (FOS) is an effective antibiotic against multidrug-resistant Enterobacterales, but its effectiveness is reducing. Little is known on the current prevalence of FosA enzymes in low-risk pathogens, such as Citrobacter ...

    • Hidden potential of hydrazinecarboxamides (semicarbazides) as potential antimicrobial agents: A review 

      přehledový článek

      open access

      vydavatelská verze

      Creative Commons License Icon

      Creative Commons BY Icon

      Krátký, Martin

      ;

      Houngbedji, Neto-Honorius

      ;

      Vinšová, Jarmila

      2024

      ,

      Biomedicine & Pharmacotherapy

      ,

      180

      (November)

      Hydrazinecarboxamides (semicarbazides) are increasingly recognized as a versatile scaffold in developing potential antimicrobial agents. In addition to a brief overview of the synthetic methods to prepare them, this review ...