Repozitář publikační činnosti UK: Poslední příspěvky
Zobrazují se záznamy 2161-2180 z 2182
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Engine shutdown: Migrastatic strategies and prevention of metastases
přehledový článek
embargo
vydavatelská verze
2023
,Trends in Cancer
,9
(4)
Most cancer-related deaths among patients with solid tumors are caused by metastases. Migrastatic strategies represent a unique therapeutic approach to prevent all forms of cancer cell migration and invasion. Because the ...
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Publication and Attenuation Biases in Measuring Skill Substitution
původní článek
embargo
preprint
2024
,Review of Economics and Statistics
,106
(5)
A key parameter in the analysis of wage inequality is the elasticity of substitution between skilled and unskilled labor. We show that the empirical literature is consistent with both publication and attenuation bias in ...
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Low-Temperature Annealing of CdZnTeSe under Bias
původní článek
open access
vydavatelská verze
2022
,MDPI
,Sensors
,22
(1)
We performed a gradual low-temperature annealing up to 360 K on a CdZnTeSe radiation detector equipped with gold and indium electrodes under bias at both polarities. We observed significant changes in the detector's ...
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Projected changes in mean annual cycle of temperature and precipitation over the Czech Republic: Comparison of CMIP5 and CMIP6
původní článek
open access
vydavatelská verze
2022
,FRONTIERS MEDIA SA
,Frontiers in Earth Science [online]
,10
(6.10.2022)
The multi-model ensembles like CMIP5 or CMIP6 provide a tool to analyze structural uncertainty of climate simulations. Currently developed regional and local climate change scenarios for the Czech Republic assess the ...
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The Role of IL-6 in Cancer Cell Invasiveness and Metastasis — Overview and Therapeutic Opportunities
přehledový článek
open access
vydavatelská verze
2022
,Cells
,11
(22)
Interleukin 6 (IL-6) belongs to a broad class of cytokines involved in the regulation of various homeostatic and pathological processes. These activities range from regulating embryonic development, wound healing and ageing, ...
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PD1+CD8+ Cells Are an Independent Prognostic Marker in Patients with Head and Neck Cancer
původní článek
embargo
vydavatelská verze
2022
,Biomedicines
,10
(11)
Head and neck squamous cell carcinomas (HNSCCs) belong to a group of diverse tumors, which can be induced by infection with human papillomavirus (HPV) or tobacco and alcohol con sumption. The viral etiology of HNSCC relates ...
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Future changes in snowpack will impact seasonal runoff and low flows in Czechia
původní článek
open access
vydavatelská verze
2021
,Journal of Hydrology: Regional Studies [online]
,37
(October)
Study Region Central Europe, Czechia. Study Focus Mountains are referred to as "water towers" because they substantially affect the hydrology of downstream areas. However, snow storages will decrease in the future due to ...
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Electrophysiological and computational analysis of Ca(v)3.2 channel variants associated with familial trigeminal neuralgia
původní článek
embargo
vydavatelská verze
2022
,Molecular Brain
,15
(November)
Trigeminal neuralgia (TN) is a rare form of chronic neuropathic pain characterized by spontaneous or elicited paroxysms of electric shock-like or stabbing pain in a region of the face. While most cases occur in a sporadic ...
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Phlebovirus Transmission by Sand Flies
abstrakt v konferenčním sborníku
open access
postprint
2022
,Praha
,Czech Chemical Society Symposium Series
,20
(6)
Arboviruses of the genus Phlebovirusare currently represented by 67 species found in Eurasia, Africa, and the Americas1. Although they have a great impact on human and animal health, information about their biology ...
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Transcription apparatus of the yeast virus-like elements is closely related to the poxviral transcription apparatus
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2022
,Praha
,Czech Chemical Society Symposium Series
,20
(6)
We employed virus-like elements (VLEs) pGKL1,2 from Kluyveromyces lactisas a model to investigate the previously neglected transcriptome of the broader group of yeast cytoplasmic linear dsDNA VLEs. We found that RNA ...
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Understanding the molecular mechanisms of viruses and host interactions
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2022
,Praha
,Czech Chemical Society Symposium Series
,20
(6)
Our research is focused on two objectives, first, the study of interactions between nuclear proteins and viral components which could result in the restriction or establishment of the infection, and second, the elucidation ...
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Role of PML nuclear bodies during mouse polyomavirus infection: PML protein isoforms and the non-canonical histone H3.3
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2022
,Praha
,Czech Chemical Society Symposium Series
,20
(6)
The possible restriction function of promyelocytic nuclear bodies (PML NBs) and their associated proteins in polyomavirus infection was studied. At first, We found that the absence of PML protein positively affects the ...
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Understanding the molecular bases of innate immune responses to foreign or mislocalized self-DNA
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2022
,Praha
,Czech Chemical Society Symposium Series
,20
(6)
We previously described that Murine polyomavirus MPyV induces type I interferon (IFN) responses via the sensors, p204 (human IFI16 homolog) and cGAS which sense viral genomes and micronucleus-like bodies generated during ...
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Skin and oral virome in psoriasis patients on biologic therapy
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2022
,Praha
,Czech Chemical Society Symposium Series
,20
(6)
The viral communities represent the most abundant microbiota population in humans. Viruses, together with other microbiota such as bacteria and fungi, form a dynamic ecosystem that influences the health of the host. The ...
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Current research on A-to-I editing in the Laboratory of RNA biochemistry, Faculty of Science, Charles University
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2022
,Praha
,Czech Chemical Society Symposium Series
,20
(6)
The paper summarizes the current status and planned research in the field of RNA editing at the Laboratory of RNA Biochemistry, Faculty of Science, Charles University
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Bioinformatics analysis of immune characteristics in tumors with alternative tumorigenesis pathways associated with human papillomaviruses
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2022
,Praha
,Czech Chemical Society Symposium Series
,20
(6)
Human papillomaviruses induce a subset of head and neck squamous cell carcinomas and anogenital cancers, particularly cervical cancer. The main viral proteins that contribute to tumorigenesis are the E6 and E7 oncoproteins, ...
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Group of cancer immunotherapy and molecular epidemiology of virus infections
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2022
,Praha
,Czech Chemical Society Symposium Series
,20
(6)
The group is composed of the team of Laboratory of Molecular and Tumor Virology (headed by Ruth Tachezy) and Laboratory of Immunotherapy (headed by Michal Šmahel). While the research of the team led by Ruth Tachezy focuses ...
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Discovery of new antiviral defense mechanisms
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2022
,Praha
,Czech Chemical Society Symposium Series
,20
(3)
In this project, we will study mechanisms of hepatitis B virus escape from adaptive and innate immunity to discover novel antiviral therapeutic targets for the development of drugs to treat chronically infected patients
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Development of antimicrobial agents with activity against drug-resistant bacteria
abstrakt v časopisu
open access
vydavatelská verze
2022
,Czech Chemical Society Symposium Series
,20
(6)
Tuberculosis (TB) is a widespread infectious disease predominantly caused by Mycobacterium tuberculosis (M. tuberculosis). The discovery and widespread use of antimicrobials effective against TB starting in the middle of ...
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Vitamin D3 Supplementation: Comparison of 1000 IU and 2000 IU Dose in Healthy Individuals
původní článek
embargo
vydavatelská verze
2023
,Life
,13
(3)
Background: Scientific studies point to a significant global vitamin D deficiency. The recommended dose of vitamin D for the adult population in Central Europe is 800-2000 IU/day. The aim of our study was to determine ...
