Repozitář publikační činnosti UK: Poslední příspěvky
Zobrazují se záznamy 321-340 z 2148
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Akty agentur EU a jejich právní (ne)závaznost
Acts of EU Agencies and Their Legal (Non-)Binding Nature
příspěvek v recenzovaném konferenčním sborníku
open access
vydavatelská verze
2025
,Plzeň
,Západočeská univerzita v Plzni, Univerzitní 2732/8, 301 00 Plzeň
,Naděje právní vědy 2024
Z historických konstitučních důvodů agentury EU nedisponují pravomocí vydávat obecně závazné akty, hard law. To staví výrazná omezení pro postavení agentur jako samostatných regulačních orgánů. Cestou z této situace proto ...
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Assessing potentially inappropriate medication use among older adults in Central and Eastern Europe
původní článek
open access
vydavatelská verze
2025
,Published for the Finnish Medical Society Duodecim by the Royal Society of Medicine Press
,Annals of Medicine
,57
(1)
Objective The aim of this study was to examine the prevalence of potentially inappropriate medication (PIM) use and its associated risk factors in community-dwelling older adults from five Central and Eastern European (CEE) ...
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Anticholinergic and Sedative Medication Burden in Croatian Older Adults: EuroAgeism Cohort Findings
původní článek
open access
vydavatelská verze
2025
,MDPI AG
,Pharmacy
,13
(5)
Use of anticholinergic and sedative medications is potentially inappropriate in older adults due to associated adverse effects, including impaired cognitive and physical function. This study evaluated anticholinergic and ...
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Circulating tumor DNA as a powerful tool in diagnostics and treatment outcome prediction - focus on large B-cell lymphomas and follicular lymphomas
přehledový článek
open access
vydavatelská verze
2025
,Informa Plc
,Expert Review of Molecular Diagnostics
,25
(6)
INTRODUCTION: Pathogenesis of large B-cell lymphomas (LBCL) and follicular lymphomas (FL) is a multistep process associated with development of diverse DNA alterations and consequent deregulation of critical cellular ...
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Deficiency of miR-155 in leukemic B-cells results in cell cycle arrest and deregulation of MIR155HG/TP53INP1/CDKN1A/CCND1 network
původní článek
open access
vydavatelská verze
2025
,Archives of Medical Research
,56
(3)
Background. Cell cycle progression and leukemia development are tightly regulated processes in which even a small imbalance in the expression of cell cycle regulatory molecules and microRNAs (miRNAs) can lead to an increased ...
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EVIDENCE BASED SELECTION OF HYPERPARAMETERS FOR EPITHELIAL SEGMENTATION IN WHOLE SLIDE IMMUNOHISTOCHEMISTRY IMAGES: FROM NORMAL MUCOSA TO COLORECTAL CANCER
původní článek
open access
preprint
2026
Background. Accurate delineation of the epithelial compartment is a critical prerequisite for reproducible quantitative analysis in digital pathology, particularly in colorectal cancer (CRC) where malignant glands determine ...
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Spatial patterns and prognostic relevance of CD1a+ immature and CD208+ mature dendritic cells in colorectal cancer from non-tumor adjacent mucosa to liver metastases
původní článek
open access
vydavatelská verze
2026
,Springer
,Cancer Immunology, Immunotherapy
,75
(1)
Background. The prognostic role of dendritic cells (DCs) in colorectal cancer (CRC) and paired livermetastases (LM) remains unclear, particularly regarding the dynamics of immature CD1a+ and matureCD208+ subsets across ...
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Exploring the full spectrum of reproductive experiences
původní článek
open access
vydavatelská verze
2026
,University of Bamberg Press
,Journal of Family Research
,38
(January 13)
Objective: The study examines changes across cohorts in terms of the timing and frequency of the full spectrum of reproductive events and explores whether these reproductive trajectories reflect broader trends towards the ...
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Serum bilirubin concentrations and their association with clinical and radiological outcomes in multiple sclerosis: A large cohort study
původní článek
open access
vydavatelská verze
2026
,Elsevier España
,Annals of Hepatology
,31
(1)
Introduction and Objectives: Bilirubin is negatively associated with neurodegenerative diseases, including multiple sclerosis (MS). Since previous studies were small or did not evaluate all diagnostic aspects, the objective ...
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Ruthenium-enhanced curcumin derivatives target tumor growth and cancer-related inflammation in head and neck cancer models
původní článek
open access
vydavatelská verze
2025
,Frontiers Media SA
,Frontiers in Oncology
,15
(December)
Introduction Head and neck cancers (HNC) remain a significant clinical challenge, particularly due to their association with chronic inflammation triggered by tobacco carcinogens and human papillomavirus (HPV) infection. ...
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Exploring the full spectrum of reproductive experiences
původní článek
open access
vydavatelská verze
2026
,University of Bamberg Press
,Journal of Family Research
,38
(January 13)
Objective: The study examines changes across cohorts in terms of the timing and frequency of the full spectrum of reproductive events and explores whether these reproductive trajectories reflect broader trends towards the ...
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Targeting tumors and inflammation: A quinoline–chalcone ruthenium complex with therapeutic promise
původní článek
open access
vydavatelská verze
2026
,Elsevier
,Biomedicine & Pharmacotherapy
,194
(January)
Head and neck cancers remain among the most challenging malignancies to treat and are often linked to lifestyle-related risk factors such as smoking and alcohol consumption. These factors not only initiate tumor development ...
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Enhancing abdominal wall healing using an oriented polycaprolactone microfibrous scaffold prepared using the fiber drawing method: A rabbit model study
původní článek
open access
vydavatelská verze
2026
,Springer-Verlag France
,Hernia
,30
(1)
PURPOSE: Incisional hernia is a common postoperative complication following abdominal surgery. Despite the use of synthetic meshes, recurrence rates remain high. This study aimed to develop and evaluate a biodegradable, ...
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Parental decision-making regarding vaccination: the role of preschool enrolment sanctions, family policies and childcare expectation
původní článek
open access
vydavatelská verze
2025
,Taylor & Francis
,European Societies
,27
(5)
The Czech Republic exemplifies a country with a mandatory childhood vaccination system. A child who has not completed compulsory vaccinations cannot be admitted to preschool until age 5. This paper discusses this measure's ...
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Environmental stability of untreated neutral metalliferous mine drainage sludge after 100 years of weathering
původní článek
open access
vydavatelská verze
2025
,Kluwer
,Environmental Geochemistry and Health
,47
(12)
Untreated neutral metalliferous mine drainage sludge deposited without environmental protection for over a century was studied to assess its long-term stability. The lack of long-term stability data on such untreated sludge ...
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Silver is immobile in Ag-rich mine waste: Isotopic evidence from anthropogenic soils
původní článek
open access
vydavatelská verze
2026
,Elsevier
,Journal of Geochemical Exploration
,282
(March)
This study presents silver (Ag) stable isotope ratios (expressed as delta Ag-109) combined with mineralogy and speciation data in Ag-contaminated anthropogenic soils from a historic mining area at Kutna Hora, Czech Republic. ...
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Mutational landscape of lung adenocarcinoma in Czechia
původní článek
open access
vydavatelská verze
2026
,Elsevier Inc.
,Cancer Treatment and Research Communications
,46
(January)
Limited DNA sequencing data on lung cancer (LC) patients are available from Eastern Europe where male smoking is commonest in Europe. As sequence analysis is the prerequisite for targeted therapy we provide such data from ...
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Dopady pandemie covidu-19 na vnímání rizika a naplňování péče v rámci různých „světů“ zaměstnanců domova pro seniory
Exploring the Effects of the Covid-19 Pandemic on Risk Perception and Care Dynamics Among Staff in Residential Homes for Older Adults
původní článek
open access
vydavatelská verze
2025
,Sociologický ústav AV ČR v.v.i.
,Sociologický časopis / Czech Sociological Review
Tato studie si klade za cíl rozšířit porozumění dopadu pandemie Covid-19 a souvisejících opatření na fungování zařízení dlouhodobé péče pro starší osoby a na zaměstnance pracující v těchto institucích. Článek prezentuje ...
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Vector competence of sand flies to Leishmania parasites and Toscana virus
abstrakt v konferenčním sborníku
open access
postprint
2025
,9th Society for Vector Ecology (SOVE) International Congress: Connecting Vector Science Globally - Abstract Book
Phlebotomine sand flies transmit a range of human pathogens, including Leishmania parasites and viruses such as Toscana virus (TOSV). Recent studies have shown that Phlebotomus tobbi and P. sergenti, two species widespread ...
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Dynamic shifts in trophoblast nucleos(t)ide metabolism, transport, and adenosine signaling during gestation and preterm birth
původní článek
open access
vydavatelská verze
2025
,Springer Nature
,Scientific Reports
,15
(1)
Nucleos(t)ides are essential for DNA/RNA synthesis, energy metabolism, and signaling, yet their roles in placental development remain poorly understood. The placenta undergoes dynamic metabolic adaptations throughout ...
