Repozitář publikační činnosti UK: Poslední příspěvky
Zobrazují se záznamy 461-480 z 938
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Sand Flies and Toscana Virus
abstrakt v konferenčním sborníku
open access
postprint
2023
,Česká společnost chemická
,Czech Chemical Society Symposium Series
,21
(5)
Phlebovirus toscanaense (Toscana virus, TOSV) from the Phenuiviridae family is an emerging but still neglected human pathogen. Infections vary from non-symptomatic forms through febrile illness to CNS disease, rarely death. ...
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Understanding the interplay between MPyV infection and nuclear lamina
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2023
,Czech Chemical Society Symposium Series
,21
(5)
The nuclear lamina (NL) is a dense meshwork of intermediate filaments V, type A lamins (lamin A/C), type B lamins and membrane associated proteins. It is located below the inner nuclear membrane. NL maintains the shape and ...
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PML nuclear bodies orchestrate antiviral response in HBV-infected hepatocytes
abstrakt v konferenčním sborníku
open access
postprint
2023
,Czech Chemical Society Symposium Series
,21
(5)
Promyelocytic leukaemia nuclear bodies (PML-NBs) play roles in various cellular functions and represent a key component of antiviral defense. In the case of hepatitis B virus (HBV), the antiviral ...
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MiRNA146a is a key component of immunnosupressive environment of hepatocytes chronically infected with HBV and melanoma cells
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2023
,Czech Chemical Society Symposium Series
,21
(5)
Interferon alfa (IFNα) is a pro-inflammatory cytokine with antiviral properties. Our project focuses on Toll-like receptors (TLR)7/9, which upon activation lead to a massive production of INFα.1Therefore, the process needs ...
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Role of the PML nuclear bodies and its associated histones chaperones in the remodeling of mouse polyomavirus minichromosomes
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2023
,Czech Chemical Society Symposium Series
,21
(5)
Polyomaviruses (PyVs) are small non-enveloped viruses replicating in the host cell nucleus. Viral replication centers (VRCs) share features with cellular euchromatic or heterochromatic regions, depending on the stage of ...
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STING agonists activate multiple regulated cell death mechanisms in monocytes
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2023
,Czech Chemical Society Symposium Series
,21
(5)
Stimulation of the innate immune responses using agonist of pattern recognition receptors is one of the investigated therapeutic approaches for treatment of chronic diseases, such as cancer or chronic ...
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Torque teno virus infection among psoriasis patients on biologic therapy
abstrakt v konferenčním sborníku
open access
postprint
2023
,Czech Chemical Society Symposium Series
,21
(5)
Torque teno virus (TTV) is a ubiquitous member of the healthy human virome with broad tissue tropism. TTV can induce chronic active infection without clinical manifestations. Although little is known about ...
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Creating a cell line suitable for investigation into the ADAR1 role in hepatitis C virus replication
abstrakt v konferenčním sborníku
open access
postprint
2023
,Czech Chemical Society Symposium Series
,21
(5)
Adenosine deaminases acting on RNA (ADAR) perform the adenosine to inosine (A-to-I) type of editing. Out of the three human ADAR proteins, ADAR1 is responsible for the majority of A-to-I editing of dsRNA outside the ...
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Absence of 5' methylguanosine cap in postreplicative genes' transcripts of Vaccinia virus
abstrakt v konferenčním sborníku
open access
postprint
2023
,Czech Chemical Society Symposium Series
,21
(5)
The Vaccinia virus (VACV) played a pivotal role in the discovery of the 5' mRNA. Over the past decades, VACV investigation has contributed extensively to understanding the mechanism behind 5' mRNA cap synthesis. ...
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Blood parasites (Trypanosoma, Leucocytozoon, Haemoproteus) in the Eurasian sparrowhawk (Accipiter nisus): diversity, incidence and persistence of infection at the individual level
původní článek
open access
vydavatelská verze
2023
,Parasites & Vectors
,16
(1)
Background :A high prevalence of parasites may result from life-long persistence of infection or from high reinfection rates. We have studied blood parasites in a breeding population of the accipitrid raptor, Eurasian ...
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Same data, different conclusions: Radical dispersion in empirical results when independent analysts operationalize and test the same hypothesis
původní článek
open access
vydavatelská verze
2021
,Organizational Behavior and Human Decision Processes
,165
(1)
In this crowdsourced initiative, independent analysts used the same dataset to test two hypotheses regarding the effects of scientists' gender and professional status on verbosity during group meetings. Not only the analytic ...
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Genetic analysis challenges the presence of Ixodes inopinatus in Central Europe: Development of a multiplex PCR to distinguish I. inopinatus from I. ricinus
původní článek
open access
vydavatelská verze
2023
,Parasites & Vectors
,16
(1)
Background Ixodes ricinus is an important vector of several pathogens, primarily in Europe. Recently, Ixodes inopinatus was described from Spain, Portugal, and North Africa and then reported from several European countries. ...
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Exploring the molecular mechanisms used by human BK polyomavirus to activate immune responses in "reservoir cells"
abstrakt v konferenčním sborníku
open access
vydavatelská verze
2023
,Czech Chemical Society Symposium Series
,21
(5)
At present, the Polyomaviridae family contains 14 human polyomaviruses (PyVs), among the most important are Merkel cell polyomavirus (MCPyV), the etiological agent of 80% of Merkel cell carcinomas, JCPyV and BKPyV causing ...
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Characterization of a human placental clearance system to regulate serotonin levels in the fetoplacental unit
původní článek
open access
vydavatelská verze
2023
,Reproductive Biology and Endocrinology
,21
(1)
Background Serotonin (5-HT) is a biogenic monoamine with diverse functions in multiple human organs and tissues. During pregnancy, tightly regulated levels of 5-HT in the fetoplacental unit are critical for proper placental ...
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TET protein inhibitors: Potential and limitations
přehledový článek
open access
vydavatelská verze
2023
,Biomedicine & Pharmacotherapy
,166
(October)
TET proteins (methylcytosine dioxygenases) play an important role in the regulation of gene expression. Dysregulation of their activity is associated with many serious pathogenic states such as oncological diseases. ...
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Phosphorylation of tyrosine 90 in SH3 domain is a new regulatory switch controlling Src kinase
původní článek
open access
vydavatelská verze
2023
,eLife
,12
(July)
The activation of Src kinase in cells is strictly controlled by intramolecular inhibitory interactions mediated by SH3 and SH2 domains. They impose structural constraints on the kinase domain holding it in a catalytically ...
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Double perovskite Cs2AgBiBr6 radiation sensor: synthesis and characterization of single crystals
původní článek
open access
vydavatelská verze
2022
,Journal of Materials Science [online]
,57
(4)
Single crystals of lead-free halide double perovskite Cs(2)AgBiBr(6) sensor material manifest a remarkable potential for application in radiation detection and imaging. In this study, the purity and crystallinity of ...
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HBV-induced microenvironment reduces pDC response to TLR7/9 stimulation
abstrakt v elektronické podobě
open access
vydavatelská verze
2023
Hepatitis B virus (HBV) is an infectious agent that causes acute hepatitis, but can also leadto chronic inflammation, and, consequently, to hepatocellular carcinoma. HBV is described as"stealth virus", since it avoids ...
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Clinical Experience with Autofluorescence Guided Oral Squamous Cell Carcinoma Surgery
původní článek
open access
vydavatelská verze
2023
,Diagnostics
,13
(20)
In our study, the effect of the use of autofluorescence (Visually Enhanced Lesion Scope-VELscope) on increasing the success rate of surgical treatment in oral squamous carcinoma (OSCC) was investigated. Our hypothesis was ...
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Carl Schmitt and Democratic Backsliding
původní článek
embargo
xmlui.dri2xhtml.METS-1.0.item-publication-version-updatedVersion
2023
,Contemporary Political Theory
,22
(3)
This Critical Exchange suggests that Schmittian inspirations abound in countries that experience democratic backsliding. Sometimes, Schmitt's ideas are used explicitly, but more often they are implicit in the actions of ...
