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Group of cancer immunotherapy and molecular epidemiology of virus infections
(Praha, 2022)
The group is composed of the team of Laboratory of Molecular and Tumor Virology (headed by Ruth Tachezy) and Laboratory of Immunotherapy (headed by Michal Šmahel). While the research of the team led by Ruth Tachezy focuses ...
The microenvironment of HPV-associated and HPV-negative oropharyngeal tumors
(Řím, 2023)
Patients with HPV-associated oropharyngeal tumors have a survival advantage. They have better treatment response and less frequently develop recurrence. This recognition led to the inclusion of the indirect marker of an ...
Specific Immune Response Against SARS-CoV-2
(2023)
The SARS-CoV-2 coronavirus, causing COVID-19 disease, has killed almost 7 million people worldwide. For effective treatment and introduction of appropriate antipandemic measures, it is necessary to understand the development ...
Human polyomaviruses in psoriasis patients on biologic treatment
(2023)
Biologic therapy poses a higher risk of viral infection for patients, however current knowledge of human polyomavirus infection in psoriasis patients is stilllimited. In this study, we evaluate the prevalence of BK ...
The detection of hypoxia markers in non-HPV and HPV-associated head and neck cancers: implications to patient survival
(2023)
In the microenvironment of growing solid tumors, oxygen level often decreases and a hypoxic state is induced. This can lead to a worse treatment response and poor patient prognosis. One of the hypoxia-responsive genes ...
Skin and oral virome in psoriasis patients on biologic therapy
(Praha, 2022)
The viral communities represent the most abundant microbiota population in humans. Viruses, together with other microbiota such as bacteria and fungi, form a dynamic ecosystem that influences the health of the host. The ...
Torque teno virus infection among psoriasis patients on biologic therapy
(2023)
Torque teno virus (TTV) is a ubiquitous member of the healthy human virome with broad tissue tropism. TTV can induce chronic active infection without clinical manifestations. Although little is known about ...
The differences in virome from distinct anatomical locations in psoriasis patients
(Česká zemědělská univerzita, Praha, 2024)
Psoriasis, a chronic autoimmune inflammatory disorder affecting 2-3% of the global population,exhibits a multifactorial aetiology with a significant genetic component and triggers such as trauma orinfection.
Specific Immunity to SARS-CoV-2 Infection
(Česká zemědělská univerzita, Praha, 2024)
The SARS-CoV-2 coronavirus, causing COVID-19 disease, has killed almost 7 million people worldwide.For effective treatment and introduction of appropriate anti-pandemic measures, it is necessary tounderstand the development ...