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Group of cancer immunotherapy and molecular epidemiology of virus infections
(Praha, 2022)
The group is composed of the team of Laboratory of Molecular and Tumor Virology (headed by Ruth Tachezy) and Laboratory of Immunotherapy (headed by Michal Šmahel). While the research of the team led by Ruth Tachezy focuses ...
The microenvironment of HPV-associated and HPV-negative oropharyngeal tumors
(Řím, 2023)
Patients with HPV-associated oropharyngeal tumors have a survival advantage. They have better treatment response and less frequently develop recurrence. This recognition led to the inclusion of the indirect marker of an ...
PD1+CD8+ Cells Are an Independent Prognostic Marker in Patients with Head and Neck Cancer
(2022)
Head and neck squamous cell carcinomas (HNSCCs) belong to a group of diverse tumors, which can be induced by infection with human papillomavirus (HPV) or tobacco and alcohol con sumption. The viral etiology of HNSCC relates ...
The detection of hypoxia markers in non-HPV and HPV-associated head and neck cancers: implications to patient survival
(2023)
In the microenvironment of growing solid tumors, oxygen level often decreases and a hypoxic state is induced. This can lead to a worse treatment response and poor patient prognosis. One of the hypoxia-responsive genes ...