dc.contributor.author | Ali, Esraa | |
dc.contributor.author | Trailin, Andriy | |
dc.contributor.author | Ambrożkiewicz, Filip | |
dc.contributor.author | Liška, Václav | |
dc.contributor.author | Hemminki, Kari Jussi | |
dc.date.issued | 2022 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14178/1624 | |
dc.description.abstract | Hepatocellular carcinoma (HCC) is a global healthcare challenge, which affects more than 815,000 new cases every year. Activated hepatic stellate cells (aHSCs) remain the principal cells that drive HCC onset and growth. aHSCs suppress the anti-tumor immune response through interaction with different immune cells. They also increase the deposition of the extracellular matrix proteins, challenging the reversion of fibrosis and increasing HCC growth and metastasis. Therapy for HCC was reported to activate HSCs, which could explain the low efficacy of current treatments. Conversely, recent studies aimed at the deactivation of HSCs show that they have been able to inhibit HCC growth. In this review article, we discuss the role of aHSCs in HCC pathophysiology and therapy. Finally, we provide suggestions for the experimental implementation of HSCs in HCC therapies. | en |
dc.language.iso | en | |
dc.relation.url | https://www.mdpi.com/1422-0067/23/23/15292 | |
dc.rights | Creative Commons Uveďte původ 4.0 International | cs |
dc.rights | Creative Commons Attribution 4.0 International | en |
dc.title | Activated Hepatic Stellate Cells in Hepatocellular Carcinoma: Their Role as a Potential Target for Future Therapies | en |
dcterms.accessRights | embargoedAccess | |
dcterms.license | https://creativecommons.org/licenses/by/4.0/legalcode | |
dc.date.updated | 2023-10-02T06:12:44Z | |
dc.subject.keyword | hepatocellular carcinoma | en |
dc.subject.keyword | hepatic stellate cells | en |
dc.subject.keyword | fibrosis regression | en |
dc.subject.keyword | therapeutic studies | en |
dc.relation.fundingReference | info:eu-repo/grantAgreement/FN/I-FN/I-FNP-04 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/EU/FP8/856620 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MZ0/NU/NU21-03-00506 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MZ0/NU/NU21-03-00145 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/UK/COOP/COOP | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM//LX22NPO5102 | |
dc.date.embargoStartDate | 2023-10-02 | |
dc.date.embargoEndDate | 2022-12-05 | |
dc.type.obd | 73 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | |
dc.identifier.doi | 10.3390/ijms232315292 | |
dc.identifier.utWos | 000896164200001 | |
dc.identifier.eidScopus | 2-s2.0-85143768079 | |
dc.identifier.obd | 618820 | |
dc.identifier.riv | RIV/00216208:11140/22:10451161 | |
dc.identifier.riv | RIV/00669806:_____/22:10451161 | |
dc.identifier.pubmed | 36499616 | |
dc.subject.rivPrimary | 30000::30200::30204 | |
dcterms.isPartOf.name | International Journal of Molecular Sciences | |
dcterms.isPartOf.issn | 1661-6596 | |
dcterms.isPartOf.journalYear | 2022 | |
dcterms.isPartOf.journalVolume | 23 | |
dcterms.isPartOf.journalIssue | 23 | |
uk.faculty.primaryId | 111 | |
uk.faculty.primaryName | Lékařská fakulta v Plzni | cs |
uk.faculty.primaryName | Faculty of Medicine in Pilsen | en |
uk.faculty.secondaryId | 54 | |
uk.faculty.secondaryName | Fakultní nemocnice Plzeň | cs |
uk.faculty.secondaryName | University Hospital in Pilsen | en |
uk.department.primaryId | 100012968318 | |
uk.department.primaryName | Biomedicínské centrum | cs |
uk.department.primaryName | Biomedical Center | en |
uk.department.secondaryId | 1399 | |
uk.department.secondaryId | 5000002701 | |
uk.department.secondaryName | Chirurgická klinika | cs |
uk.department.secondaryName | Department of Surgery | en |
uk.department.secondaryName | Chirurgická klinika | cs |
uk.department.secondaryName | Department of Surgery | en |
dc.type.obdHierarchyCs | ČLÁNEK V ČASOPISU::článek v časopisu::přehledový článek | cs |
dc.type.obdHierarchyEn | JOURNAL ARTICLE::journal article::summarizing article | en |
dc.type.obdHierarchyCode | 73::152::205 | en |
uk.displayTitle | Activated Hepatic Stellate Cells in Hepatocellular Carcinoma: Their Role as a Potential Target for Future Therapies | en |