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Activated Hepatic Stellate Cells in Hepatocellular Carcinoma: Their Role as a Potential Target for Future Therapies

dc.contributor.authorAli, Esraa
dc.contributor.authorTrailin, Andriy
dc.contributor.authorAmbrożkiewicz, Filip
dc.contributor.authorLiška, Václav
dc.contributor.authorHemminki, Kari Jussi
dc.date.issued2022
dc.identifier.urihttps://hdl.handle.net/20.500.14178/1624
dc.description.abstractHepatocellular carcinoma (HCC) is a global healthcare challenge, which affects more than 815,000 new cases every year. Activated hepatic stellate cells (aHSCs) remain the principal cells that drive HCC onset and growth. aHSCs suppress the anti-tumor immune response through interaction with different immune cells. They also increase the deposition of the extracellular matrix proteins, challenging the reversion of fibrosis and increasing HCC growth and metastasis. Therapy for HCC was reported to activate HSCs, which could explain the low efficacy of current treatments. Conversely, recent studies aimed at the deactivation of HSCs show that they have been able to inhibit HCC growth. In this review article, we discuss the role of aHSCs in HCC pathophysiology and therapy. Finally, we provide suggestions for the experimental implementation of HSCs in HCC therapies.en
dc.language.isoen
dc.relation.urlhttps://www.mdpi.com/1422-0067/23/23/15292
dc.rightsCreative Commons Uveďte původ 4.0 Internationalcs
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.titleActivated Hepatic Stellate Cells in Hepatocellular Carcinoma: Their Role as a Potential Target for Future Therapiesen
dcterms.accessRightsembargoedAccess
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/legalcode
dc.date.updated2023-10-02T06:12:44Z
dc.subject.keywordhepatocellular carcinomaen
dc.subject.keywordhepatic stellate cellsen
dc.subject.keywordfibrosis regressionen
dc.subject.keywordtherapeutic studiesen
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/FN/I-FN/I-FNP-04
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/EU/FP8/856620
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MZ0/NU/NU21-03-00506
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MZ0/NU/NU21-03-00145
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/UK/COOP/COOP
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MSM//LX22NPO5102
dc.date.embargoStartDate2023-10-02
dc.date.embargoEndDate2022-12-05
dc.type.obd73
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.3390/ijms232315292
dc.identifier.utWos000896164200001
dc.identifier.eidScopus2-s2.0-85143768079
dc.identifier.obd618820
dc.identifier.rivRIV/00216208:11140/22:10451161
dc.identifier.rivRIV/00669806:_____/22:10451161
dc.identifier.pubmed36499616
dc.subject.rivPrimary30000::30200::30204
dcterms.isPartOf.nameInternational Journal of Molecular Sciences
dcterms.isPartOf.issn1661-6596
dcterms.isPartOf.journalYear2022
dcterms.isPartOf.journalVolume23
dcterms.isPartOf.journalIssue23
uk.faculty.primaryId111
uk.faculty.primaryNameLékařská fakulta v Plznics
uk.faculty.primaryNameFaculty of Medicine in Pilsenen
uk.faculty.secondaryId54
uk.faculty.secondaryNameFakultní nemocnice Plzeňcs
uk.faculty.secondaryNameUniversity Hospital in Pilsenen
uk.department.primaryId100012968318
uk.department.primaryNameBiomedicínské centrumcs
uk.department.primaryNameBiomedical Centeren
uk.department.secondaryId1399
uk.department.secondaryId5000002701
uk.department.secondaryNameChirurgická klinikacs
uk.department.secondaryNameDepartment of Surgeryen
uk.department.secondaryNameChirurgická klinikacs
uk.department.secondaryNameDepartment of Surgeryen
dc.type.obdHierarchyCsČLÁNEK V ČASOPISU::článek v časopisu::přehledový článekcs
dc.type.obdHierarchyEnJOURNAL ARTICLE::journal article::summarizing articleen
dc.type.obdHierarchyCode73::152::205en
uk.displayTitleActivated Hepatic Stellate Cells in Hepatocellular Carcinoma: Their Role as a Potential Target for Future Therapiesen


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