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Long Non-Coding RNA and microRNA Interplay in Colorectal Cancer and Their Effect on the Tumor Microenvironment

dc.contributor.authorRajtmajerová, Marie
dc.contributor.authorTrailin, Andriy
dc.contributor.authorLiška, Václav
dc.contributor.authorHemminki, Kari Jussi
dc.contributor.authorAmbrożkiewicz, Filip
dc.date.accessioned2022-12-14T13:40:25Z
dc.date.available2022-12-14T13:40:25Z
dc.date.issued2022
dc.identifier.urihttps://hdl.handle.net/20.500.14178/1625
dc.description.abstractAs the current staging and grading systems are not sufficient to stratify patients for therapy and predict the outcome of the disease, there is an urgent need to understand cancer in its complexity. The mutual relationship between tumour and immune or stromal cells leads to rapid evolution and subsequent genetic and epigenetic changes. Immunoscore has been introduced as a diagnostic tool for colorectal cancer (CRC) only recently, emphasising the role of the specific tumor microenvironment in patient's prognosis and overall outcome. Despite the fact that non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), cannot be translated into proteins, they significantly affect cell's transcriptome and translatome. miRNA binding to mRNA efficiently blocks its translation and leads to mRNA destruction. On the other hand, miRNAs can be bound by lncRNAs or circular RNAs (circRNAs), which prevents them from interfering with translation. In this way, ncRNAs create a multi-step network that regulates the cell's translatome. ncRNAs are also shed by the cell as exogenous RNAs and they are also found in exosomes, suggesting their role in intercellular communication. Hence, these mechanisms affect the tumor microenvironment as much as protein signal molecules. In this review, we provide an insight into the current knowledge of the microenvironment, lncRNAs', and miRNAs' interplay. Understanding mechanisms that underlie the evolution of a tissue as complex as a tumour is crucial for the future success in therapy.en
dc.language.isoen
dc.relation.urlhttps://www.mdpi.com/2072-6694/14/21/5450
dc.rightsCreative Commons Uveďte původ 4.0 Internationalcs
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.titleLong Non-Coding RNA and microRNA Interplay in Colorectal Cancer and Their Effect on the Tumor Microenvironmenten
dcterms.accessRightsembargoedAccess
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/legalcode
dc.date.updated2023-10-02T06:12:43Z
dc.subject.keywordCAFsen
dc.subject.keywordCRCen
dc.subject.keywordcolorectal canceren
dc.subject.keywordlncRNAen
dc.subject.keywordlymphocytesen
dc.subject.keywordmacrophagesen
dc.subject.keywordmiRNAen
dc.subject.keywordtumor microenvironmenten
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/EU/FP8/856620
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MZ0/NU/NU21-03-00506
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MZ0/NU/NU21-03-00145
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/UK/COOP/COOP
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MSM//LX22NPO5102
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/FN/I-FN/I-FNP-04
dc.date.embargoStartDate2023-10-02
dc.date.embargoEndDate2022-11-06
dc.type.obd73
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.3390/cancers14215450
dc.identifier.utWos000880939700001
dc.identifier.eidScopus2-s2.0-85141859885
dc.identifier.obd617934
dc.identifier.rivRIV/00216208:11140/22:10450275
dc.identifier.rivRIV/00669806:_____/22:10450275
dc.identifier.pubmed36358867
dc.subject.rivPrimary30000::30100::30101
dc.subject.rivSecondary30000::30200::30204
dcterms.isPartOf.nameCancers
dcterms.isPartOf.issn2072-6694
dcterms.isPartOf.journalYear2022
dcterms.isPartOf.journalVolume14
dcterms.isPartOf.journalIssue21
uk.faculty.primaryId111
uk.faculty.primaryNameLékařská fakulta v Plznics
uk.faculty.primaryNameFaculty of Medicine in Pilsenen
uk.faculty.secondaryId54
uk.faculty.secondaryNameFakultní nemocnice Plzeňcs
uk.faculty.secondaryNameUniversity Hospital in Pilsenen
uk.department.primaryId100012968318
uk.department.primaryNameBiomedicínské centrumcs
uk.department.primaryNameBiomedical Centeren
uk.department.secondaryId1399
uk.department.secondaryId5000002701
uk.department.secondaryNameChirurgická klinikacs
uk.department.secondaryNameDepartment of Surgeryen
uk.department.secondaryNameChirurgická klinikacs
uk.department.secondaryNameDepartment of Surgeryen
dc.type.obdHierarchyCsČLÁNEK V ČASOPISU::článek v časopisu::přehledový článekcs
dc.type.obdHierarchyEnJOURNAL ARTICLE::journal article::summarizing articleen
dc.type.obdHierarchyCode73::152::205en
uk.displayTitleLong Non-Coding RNA and microRNA Interplay in Colorectal Cancer and Their Effect on the Tumor Microenvironmenten


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