Desmin Knock-Out Cardiomyopathy: A Heart on the Verge of Metabolic Crisis
Author
Schmid, Benjamin
Mallek, Markus
Eggers, Britta
Schloetzer-Schrehardt, Ursula
Peeva, Viktoriya
Berwanger, Carolin
Eberhard, Bettina
Durmus, Hacer
Schultheis, Dorothea
Holtzhausen, Christian
Schork, Karin
Marcus, Katrin
Jordan, Jens
Luecke, Thomas
van der Ven, Peter F. M.
Schroeder, Rolf
Clemen, Christoph S.
Publication date
2022Published in
International Journal of Molecular SciencesVolume / Issue
23 (19)ISBN / ISSN
ISSN: 1661-6596Metadata
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This publication has a published version with DOI 10.3390/ijms231912020
Abstract
Desmin mutations cause familial and sporadic cardiomyopathies. In addition to perturbing the contractile apparatus, both desmin deficiency and mutated desmin negatively impact mitochondria. Impaired myocardial metabolism secondary to mitochondrial defects could conceivably exacerbate cardiac contractile dysfunction. We performed metabolic myocardial phenotyping in left ventricular cardiac muscle tissue in desmin knock-out mice. Our analyses revealed decreased mitochondrial number, ultrastructural mitochondrial defects, and impaired mitochondria-related metabolic pathways including fatty acid transport, activation, and catabolism. Glucose transporter 1 and hexokinase-1 expression and hexokinase activity were increased. While mitochondrial creatine kinase expression was reduced, fetal creatine kinase expression was increased. Proteomic analysis revealed reduced expression of proteins involved in electron transport mainly of complexes I and II, oxidative phosphorylation, citrate cycle, beta-oxidation including auxiliary pathways, amino acid catabolism, and redox reactions and oxidative stress. Thus, desmin deficiency elicits a secondary cardiac mitochondriopathy with severely impaired oxidative phosphorylation and fatty and amino acid metabolism. Increased glucose utilization and fetal creatine kinase upregulation likely portray attempts to maintain myocardial energy supply. It may be prudent to avoid medications worsening mitochondrial function and other metabolic stressors. Therapeutic interventions for mitochondriopathies might also improve the metabolic condition in desmin deficient hearts.
Keywords
desmin, desminopathy, cardiomyopathy, mitochondriopathy, desmin knock-out metabolism, glucose, fatty acid, amino acid, creatine kinase, mitochondria
Permanent link
https://hdl.handle.net/20.500.14178/1631License
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