dc.contributor.author | Šmahel, Michal | |
dc.contributor.author | Nunvář, Jaroslav | |
dc.contributor.editor | Šímová, Šárka | |
dc.date.issued | 2022 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14178/1778 | |
dc.description.abstract | Human papillomaviruses induce a subset of head and neck squamous cell carcinomas and anogenital cancers, particularly cervical cancer. The main viral proteins that contribute to tumorigenesis are the E6 and E7 oncoproteins, the expression of which is usually enhanced after the integration of viral DNA into the host genome. Recently, an alternative tumorigenesis pathway characterized by extrachromosomal HPV persistence and increased expression of the viral E2, E4, and E5 genes has been suggested. As an antitumor immune response is a crucial factor in the prognosis of HPV-driven cancers, we performed bioinformatics analysis of immune characteristics of HPV-dependent tumors and their association with types of tumorigenesis. Expression or immune-related genes, tumor-infiltrating immune cells, and overall survival were evaluated. | en |
dc.language.iso | en | |
dc.relation.url | http://www.ccsss.cz/index.php/ccsss/issue/view/37 | |
dc.rights | Tento výsledek je zpřístupněn v režimu gratis open access, tj. pouze pro čtení. V souladu s § 30 zákona č. 121/2000 Sb., autorského zákona, lze plný text z repozitáře také stáhnout, případně vytisknout, ale pouze pro osobní potřebu. | cs |
dc.rights | The fulltext is published in the repository as read-only, i.e. in gratis open access mode. Repository visitors are entitled to download and print the fulltext published without a licence for their personal use only (in accordance with § 30 of Act No. 121/2000 Coll., the Copyright Act). | en |
dc.title | Bioinformatics analysis of immune characteristics in tumors with alternative tumorigenesis pathways associated with human papillomaviruses | en |
dcterms.accessRights | openAccess | |
dc.date.updated | 2023-10-02T06:14:56Z | |
dc.subject.keyword | tumorigenesis | en |
dc.subject.keyword | papillomavirus | en |
dc.subject.keyword | carcer | en |
dc.publisher.publicationPlace | Praha | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM//LX22NPO5103 | |
dc.date.embargoStartDate | 2023-10-02 | |
dc.type.obd | 110 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | |
dc.identifier.obd | 622058 | |
dc.identifier.riv | RIV/00216208:11310/22:10454399 | |
dc.subject.rivPrimary | 30000::30200::30204 | |
dcterms.isPartOf.name | Czech Chemical Society Symposium Series | |
dcterms.isPartOf.issn | 2336-7202 | |
dcterms.isPartOf.journalYear | 2022 | |
dcterms.isPartOf.journalVolume | 20 | |
dcterms.isPartOf.journalIssue | 6 | |
uk.faculty.primaryId | 115 | |
uk.faculty.primaryName | Přírodovědecká fakulta | cs |
uk.faculty.primaryName | Faculty of Science | en |
uk.department.primaryId | 1034 | |
uk.department.primaryName | Katedra genetiky a mikrobiologie | cs |
uk.department.primaryName | Department of Genetics and Microbiology | en |
uk.event.name | The first annual meeting of the National Institute of Virology and Bacteriology (NIVB Meeting 2022) | |
dc.description.pageRange | 400-400 | |
dc.type.obdHierarchyCs | ABSTRAKT::abstrakt::abstrakt v konferenčním sborníku | cs |
dc.type.obdHierarchyEn | ABSTRACT::abstract::abstract in conference proceedings | en |
dc.type.obdHierarchyCode | 110::130::462 | en |
uk.displayTitle | Bioinformatics analysis of immune characteristics in tumors with alternative tumorigenesis pathways associated with human papillomaviruses | en |