| dc.contributor.author | Rauf, Mahd | |
| dc.contributor.author | Ryabchenko, Boris | |
| dc.contributor.author | Šroller, Vojtěch | |
| dc.contributor.author | Horníková, Lenka | |
| dc.contributor.author | Forstová, Jitka | |
| dc.contributor.author | Huérfano Meneses, Sandra | |
| dc.contributor.editor | Šímová, Šárka | |
| dc.date.issued | 2022 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14178/1791 | |
| dc.description.abstract | We previously described that Murine polyomavirus MPyV induces type I interferon (IFN) responses via the sensors, p204 (human IFI16 homolog) and cGAS which sense viral genomes and micronucleus-like bodies generated during infection1. Sensing by both DNA sensors leads to canonical STING activation. During MPyV infection, there are additional cell responses are activated such as DNA damage response and apoptosis, therefore we investigated a possible contribution of the DNA damage in the activation of a STING non-canonical pathway and the role of sublethal apoptosis in the induction of innate immune responses to the infection by MPyV. | en |
| dc.language.iso | en | |
| dc.relation.url | http://www.ccsss.cz/index.php/ccsss/issue/view/37 | |
| dc.rights | Tento výsledek je zpřístupněn v režimu gratis open access, tj. pouze pro čtení. V souladu s § 30 zákona č. 121/2000 Sb., autorského zákona, lze plný text z repozitáře také stáhnout, případně vytisknout, ale pouze pro osobní potřebu. | cs |
| dc.rights | The fulltext is published in the repository as read-only, i.e. in gratis open access mode. Repository visitors are entitled to download and print the fulltext published without a licence for their personal use only (in accordance with § 30 of Act No. 121/2000 Coll., the Copyright Act). | en |
| dc.title | Understanding the molecular bases of innate immune responses to foreign or mislocalized self-DNA | en |
| dcterms.accessRights | openAccess | |
| dc.date.updated | 2023-10-02T06:15:32Z | |
| dc.subject.keyword | canonical STING pathway | en |
| dc.subject.keyword | non-canonical STING pathway | en |
| dc.subject.keyword | sublethal apoptosis | en |
| dc.subject.keyword | mislocalized self-DNA | en |
| dc.publisher.publicationPlace | Praha | |
| dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM//LX22NPO5103 | |
| dc.date.embargoStartDate | 2023-10-02 | |
| dc.type.obd | 110 | |
| dc.type.version | info:eu-repo/semantics/publishedVersion | |
| dc.identifier.obd | 622064 | |
| dc.identifier.riv | RIV/00216208:11310/22:10454405 | |
| dc.subject.rivPrimary | 30000::30100::30102 | |
| dc.subject.rivSecondary | 10000::10600::10607 | |
| dcterms.isPartOf.name | Czech Chemical Society Symposium Series | |
| dcterms.isPartOf.issn | 2336-7202 | |
| dcterms.isPartOf.journalYear | 2022 | |
| dcterms.isPartOf.journalVolume | 20 | |
| dcterms.isPartOf.journalIssue | 6 | |
| uk.faculty.primaryId | 115 | |
| uk.faculty.primaryName | Přírodovědecká fakulta | cs |
| uk.faculty.primaryName | Faculty of Science | en |
| uk.department.primaryId | 1034 | |
| uk.department.primaryName | Katedra genetiky a mikrobiologie | cs |
| uk.department.primaryName | Department of Genetics and Microbiology | en |
| uk.event.name | The first annual meeting of the National Institute of Virology and Bacteriology (NIVB Meeting 2022) | |
| dc.description.pageRange | 398-398 | |
| dc.type.obdHierarchyCs | ABSTRAKT::abstrakt::abstrakt v konferenčním sborníku | cs |
| dc.type.obdHierarchyEn | ABSTRACT::abstract::abstract in conference proceedings | en |
| dc.type.obdHierarchyCode | 110::130::462 | en |
| uk.displayTitle | Understanding the molecular bases of innate immune responses to foreign or mislocalized self-DNA | en |
