STING agonist-induced CD14+ monocyte depletion involves multiple regulated cell death mechanisms

abstract in conference proceedings
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Author
Pimková Polidarová, MarkétaORCiD Profile - 0000-0003-3116-1328WoS Profile - V-2351-2017Scopus Profile - 57212310198
Dejmek, Milan
Hirsch, IvanORCiD Profile - 0000-0003-1701-1438WoS Profile - R-3103-2016Scopus Profile - 56275056800
Brázdová, AndreaORCiD Profile - 0000-0002-2384-6012WoS Profile - DWY-2679-2022Scopus Profile - 36023303000
Grantz Šašková, KláraORCiD Profile - 0000-0003-2874-5699WoS Profile - E-1931-2014Scopus Profile - 22954587000
Jurášek, Michal
Řápková, Radmila
Benešová, Eva
Drašar, Pavel
Czech Chemical Society,Czech Society for Biochemistry and Molecular Biology

Publication date
2023
Published in
XXIInd Interdisciplinary Meeting of Young Life Scientists
Publisher / Publication place
Česká společnost chemická (Praha)
Volume / Issue
21 (2)
ISBN / ISSN
ISSN: 2336-7202
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Abstract
The immune cells respond to the double-stranded DNA (dsDNA) or cyclic dinucleotide (CDN)-mediated stimulation of the cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway by secretion of type I interferons (IFNs) and proinflammatory cytokines.1,2 The cytokines and IFNs mediate multiple innate immune processes further bridging to adaptive immune responses, among which the antiviral defence and immune surveillance are at the forefront of research interest.
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https://hdl.handle.net/20.500.14178/1915
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