dc.contributor.author | Bauer, Dávid | |
dc.contributor.author | Neuberg, Marek | |
dc.contributor.author | Nováčková, Markéta | |
dc.contributor.author | Kočka, Viktor | |
dc.contributor.author | Toušek, Petr | |
dc.date.accessioned | 2023-06-06T08:03:36Z | |
dc.date.available | 2023-06-06T08:03:36Z | |
dc.date.issued | 2023 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14178/1925 | |
dc.description.abstract | There are several differences between younger and older adults with acute coronary syndrome (ACS). However, few studies have evaluated these differences. We analysed the pre-hospital time interval [symptom onset to first medical contact (FMC)], clinical characteristics, angiographic findings, and in-hospital mortality in patients aged <=50 (group A) and 51-65 (group B) years hospitalised for ACS. We retrospectively collected data from 2010 consecutive patients hospitalised with ACS between 1 October 2018 and 31 October 2021 from a single-centre ACS registry. Groups A and B included 182 and 498 patients, respectively. ST-segment elevation myocardial infarction (STEMI) was more common in group A than group B (62.6 and 45.6%, respectively; P < 0.001). The median time from symptom onset to FMC in STEMI patients did not significantly differ between groups A and B [74 (40-198) and 96 (40-249) min, respectively; P = 0.369]. There was no difference in the rate of sub-acute STEMI (symptom onset to FMC > 24 h) between groups A and B (10.4% and 9.0%, respectively; P = 0.579). Among patients with non-ST elevation acute coronary syndrome (NSTE-ACS), 41.8 and 50.2% of those in groups A and B, respectively, presented to the hospital within 24 h of symptom onset (P = 0.219). The prevalence of previous myocardial infarction was 19.2% in group A and 19.5% in group B (P = 1.00). Hypertension, diabetes, and peripheral arterial disease were more common in group B than group A. Active smoking was more common in group A than group B (67 and 54.2%, respectively; P = 0.021). Single-vessel disease was present in 52.2 and 37.1% of participants in groups A and B, respectively (P = 0.002). Proximal left anterior descending artery was more commonly the culprit lesion in group A compared with group B, irrespective of the ACS type (STEMI, 37.7 and 24.2%, respectively; P = 0.009; NSTE-ACS, 29.4 and 21%, respectively; P = 0.140). The hospital mortality rate for STEMI patients was 1.8 and 4.4% in groups A and B, respectively (P = 0.210), while for NSTE-ACS patients it was 2.9 and 2.6% in groups A and B, respectively (P = 0.873). No significant differences in pre-hospital delay were found between young (<=50 years) and middle-aged (51-65 years) patients with ACS. Although clinical characteristics and angiographic findings differ between young and middle-aged patients with ACS, the in-hospital mortality rate did not differ between the groups and was low for both of them. | en |
dc.language.iso | en | |
dc.relation.url | https://doi.org/10.1093/eurheartjsupp/suad102 | |
dc.rights | Creative Commons Uveďte původ-Neužívejte dílo komerčně 4.0 International | cs |
dc.rights | Creative Commons Attribution-NonCommercial 4.0 International | en |
dc.title | Pre-hospital delay, clinical characteristics, angiographic findings, and in-hospital mortality in young and middle-aged adults with acute coronary syndrome: a single-centre registry analysis | en |
dcterms.accessRights | openAccess | |
dcterms.license | https://creativecommons.org/licenses/by-nc/4.0/legalcode | |
dc.date.updated | 2023-10-02T06:17:25Z | |
dc.subject.keyword | Acute coronary syndrome | en |
dc.subject.keyword | Angiographic findings | en |
dc.subject.keyword | First medical contact | en |
dc.subject.keyword | In-hospital mortality | en |
dc.subject.keyword | Symptom onset | en |
dc.subject.keyword | Young adults | en |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM//LX22NPO5104 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/UK/COOP/COOP | |
dc.date.embargoStartDate | 2023-10-02 | |
dc.type.obd | 73 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | |
dc.identifier.doi | 10.1093/eurheartjsupp/suad102 | |
dc.identifier.utWos | 001009977800006 | |
dc.identifier.eidScopus | 2-s2.0-85161002401 | |
dc.identifier.obd | 632419 | |
dc.identifier.pubmed | 37234234 | |
dc.subject.rivPrimary | 30000::30200::30201 | |
dcterms.isPartOf.name | European Heart Journal: Supplements | |
dcterms.isPartOf.issn | 1520-765X | |
dcterms.isPartOf.journalYear | 2023 | |
dcterms.isPartOf.journalVolume | 25 | |
dcterms.isPartOf.journalIssue | Suppl. E | |
uk.faculty.primaryId | 110 | |
uk.faculty.primaryName | 3. lékařská fakulta | cs |
uk.faculty.primaryName | Third Faculty of Medicine | en |
uk.department.primaryId | 110 | |
uk.department.primaryName | 3. lékařská fakulta | cs |
uk.department.primaryName | Third Faculty of Medicine | en |
uk.department.secondaryId | 634 | |
uk.department.secondaryName | Kardiologická klinika 3. LF UK a FNKV | cs |
uk.department.secondaryName | Department of Cardiology 3FM CU and UHKV | en |
dc.description.pageRange | e33-e39 | |
dc.type.obdHierarchyCs | ČLÁNEK V ČASOPISU::článek v časopisu::původní článek | cs |
dc.type.obdHierarchyEn | JOURNAL ARTICLE::journal article::original article | en |
dc.type.obdHierarchyCode | 73::152::206 | en |
uk.displayTitle | Pre-hospital delay, clinical characteristics, angiographic findings, and in-hospital mortality in young and middle-aged adults with acute coronary syndrome: a single-centre registry analysis | en |