dc.contributor.author | Hozman, Marek | |
dc.contributor.author | Hassouna, Sabri | |
dc.contributor.author | Grochol, Lukáš | |
dc.contributor.author | Waldauf, Petr | |
dc.contributor.author | Hráček, Tomáš | |
dc.contributor.author | Zbořilová Pazdiorová, Blanka | |
dc.contributor.author | Adamec, Stanislav | |
dc.contributor.author | Osmančík, Pavel | |
dc.date.accessioned | 2023-06-06T08:03:36Z | |
dc.date.available | 2023-06-06T08:03:36Z | |
dc.date.issued | 2023 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14178/1926 | |
dc.description.abstract | The association between antithrombotics (ATs) and the risk of gastrointestinal bleeding is well known; however, data regarding the influence of ATs on outcomes are scarce. The goals of this study are: (i) to assess the impact of prior AT therapy on in-hospital and 6-month outcomes and (ii) to determine the re-initiation rate of the ATs after a bleeding event. All patients with upper gastrointestinal bleeding (UGB) who underwent urgent gastroscopy in three centres from 1 January 2019 to 31 December 2019 were retrospectively analysed. Propensity score matching (PSM) was used. Among 333 patients [60% males, mean age 69.2 (+-17.3) years], 44% were receiving ATs. In multivariate logistic regression, no association between AT treatment and worse in-hospital outcomes was observed. Development of haemorrhagic shock led to worse survival [odds ratio (OR) 4.4, 95% confidence interval (CI) 1.9-10.2, P < 0.001; after PSM: OR 5.3, 95% CI 1.8-15.7, P = 0.003]. During 6-months follow-up, higher age (OR 1.0, 95% CI 1.0-1.1, P = 0.002), higher comorbidity (OR 1.4, 95% CI 1.2-1.7, P < 0.001), a history of cancer (OR 3.6, 95% CI 1.6-8.1, P < 0.001) and a history of liver cirrhosis (OR 2.2, 95% CI 1.0-4.4, P = 0.029) were associated with higher mortality. After a bleeding episode, ATs were adequately re-initiated in 73.8%. Previous AT therapy does not worsen in-hospital outcomes in after UGB. Development of haemorrhagic shock predicted poor prognosis. Higher 6-month mortality was observed in older patients, patients with more comorbidities, with liver cirrhosis and cancer. | en |
dc.language.iso | en | |
dc.relation.url | https://doi.org/10.1093/eurheartjsupp/suad103 | |
dc.rights | Creative Commons Uveďte původ-Neužívejte dílo komerčně 4.0 International | cs |
dc.rights | Creative Commons Attribution-NonCommercial 4.0 International | en |
dc.title | Previous antithrombotic therapy does not have an impact on the in-hospital mortality of patients with upper gastrointestinal bleeding | en |
dcterms.accessRights | openAccess | |
dcterms.license | https://creativecommons.org/licenses/by-nc/4.0/legalcode | |
dc.date.updated | 2023-10-02T06:16:47Z | |
dc.subject.keyword | Anticoagulants | en |
dc.subject.keyword | Antiplatelet treatment | en |
dc.subject.keyword | Comorbidity | en |
dc.subject.keyword | Gastrointestinal haemorrhage | en |
dc.subject.keyword | Outcome assessment | en |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM//LX22NPO5104 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/UK/COOP/COOP | |
dc.date.embargoStartDate | 2023-10-02 | |
dc.type.obd | 73 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | |
dc.identifier.doi | 10.1093/eurheartjsupp/suad103 | |
dc.identifier.utWos | 001009977800005 | |
dc.identifier.eidScopus | 2-s2.0-85161043249 | |
dc.identifier.obd | 632425 | |
dc.identifier.pubmed | 37234230 | |
dc.subject.rivPrimary | 30000::30200::30201 | |
dcterms.isPartOf.name | European Heart Journal: Supplements | |
dcterms.isPartOf.issn | 1520-765X | |
dcterms.isPartOf.journalYear | 2023 | |
dcterms.isPartOf.journalVolume | 25 | |
dcterms.isPartOf.journalIssue | Suppl. E | |
uk.faculty.primaryId | 110 | |
uk.faculty.primaryName | 3. lékařská fakulta | cs |
uk.faculty.primaryName | Third Faculty of Medicine | en |
uk.department.primaryId | 110 | |
uk.department.primaryName | 3. lékařská fakulta | cs |
uk.department.primaryName | Third Faculty of Medicine | en |
uk.department.secondaryId | 634 | |
uk.department.secondaryId | 633 | |
uk.department.secondaryId | 624 | |
uk.department.secondaryId | 623 | |
uk.department.secondaryName | Kardiologická klinika 3. LF UK a FNKV | cs |
uk.department.secondaryName | Department of Cardiology 3FM CU and UHKV | en |
uk.department.secondaryName | Interní klinika 3. LF UK a FNKV | cs |
uk.department.secondaryName | Department of Internal Medicine 3FM CU and UHKV | en |
uk.department.secondaryName | Klinika anesteziologie a resuscitace 3. LF UK a FNKV | cs |
uk.department.secondaryName | Department of Anaesthesia and Intensive Care Medicine 3FM CU and UHKV | en |
uk.department.secondaryName | Chirurgická klinika 3. LF UK a FNKV | cs |
uk.department.secondaryName | Department of General Surgery 3FM CU and UHKV | en |
dc.description.pageRange | e25-e32 | |
dc.type.obdHierarchyCs | ČLÁNEK V ČASOPISU::článek v časopisu::původní článek | cs |
dc.type.obdHierarchyEn | JOURNAL ARTICLE::journal article::original article | en |
dc.type.obdHierarchyCode | 73::152::206 | en |
uk.displayTitle | Previous antithrombotic therapy does not have an impact on the in-hospital mortality of patients with upper gastrointestinal bleeding | en |