Mouse Polyomavirus Affects Nuclear Lamina in the Late Phase of Infection

Abstract

One of the important components of nuclear cytoskeleton is nuclear lamina. It is composed of intermediate filaments V, A type lamins (lamin A/C) and B type lamins (lamin B1 and B2). Although nuclear lamina maintains the structural integrity of the nucleus, it plays an important role in fine-tuning of DNA related processes, e. g. replication or transcription and is also a natural barrier for viruses replicating in the nucleus. Hence, viruses evolved different mechanisms ensuring exploitation of the lamina for their own purposes.