dc.contributor.author | Pimková Polidarová, Markéta | |
dc.contributor.author | Hirsch, Ivan | |
dc.contributor.author | Brázdová, Andrea | |
dc.contributor.author | Grantz Šašková, Klára | |
dc.date.accessioned | 2023-08-25T10:10:24Z | |
dc.date.available | 2023-08-25T10:10:24Z | |
dc.date.issued | 2023 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14178/2004 | |
dc.description.abstract | Double-stranded DNA and cyclic dinucleotides activate the cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway, which leads to the production of type I interferons (IFNs) and proinflammatory cytokines by immune cells. These compounds further mediate numerous regulatory immune processes with antiviral or antitumoral properties. Therefore, activators of the cGAS-STING pathway are being investigated for their therapeutic potential.To better understand the immune orchestration induced by STING agonists, we investigated their effect on peripheral blood mononuclear cells (PBMCs), a physiologically relevant complex of immune populations. We demonstrated that STING agonists induce the secretion of a broad portfolio of proinflammatory cytokines. However, treatment with STING agonist is also associated with robust monocyte depletion. | en |
dc.language.iso | en | |
dc.rights | Creative Commons Uveďte původ 4.0 International | cs |
dc.rights | Creative Commons Attribution 4.0 International | en |
dc.title | STING agonists induce monocyte depletion with characteristics of multiple regulated cell deaths | en |
dcterms.accessRights | openAccess | |
dcterms.license | https://creativecommons.org/licenses/by/4.0/legalcode | |
dc.date.updated | 2023-10-02T06:16:31Z | |
dc.subject.keyword | STING | en |
dc.subject.keyword | immune | en |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM//LX22NPO5103 | |
dc.date.embargoStartDate | 2023-10-02 | |
dc.contributor.organizer | Weizmann Institute of Science, spoluorganizátoři - Chemistry and Technology, Prague and Institute of Organic Chemistry a Biochemistry of the Czech Academy of Sciences | |
dc.type.obd | 110 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | |
dc.identifier.obd | 633975 | |
dc.subject.rivPrimary | 30000::30100::30102 | |
dcterms.isPartOf.name | 9th Prague-Weizmann Summer School in Drug Discovery & Development | |
dcterms.isPartOf.journalYear | 2023 | |
uk.faculty.primaryId | 115 | |
uk.faculty.primaryName | Přírodovědecká fakulta | cs |
uk.faculty.primaryName | Faculty of Science | en |
uk.department.primaryId | 1034 | |
uk.department.primaryName | Katedra genetiky a mikrobiologie | cs |
uk.department.primaryName | Department of Genetics and Microbiology | en |
uk.event.name | 9th Prague-Weizmann Summer School in Drug Discovery & Development | |
dc.type.obdHierarchyCs | ABSTRAKT::abstrakt::abstrakt v elektronické podobě | cs |
dc.type.obdHierarchyEn | ABSTRACT::abstract::abstract in e-form | en |
dc.type.obdHierarchyCode | 110::130::136 | en |
uk.displayTitle | STING agonists induce monocyte depletion with characteristics of multiple regulated cell deaths | en |