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STING agonists induce monocyte depletion with characteristics of multiple regulated cell deaths

dc.contributor.authorPimková Polidarová, Markéta
dc.contributor.authorHirsch, Ivan
dc.contributor.authorBrázdová, Andrea
dc.contributor.authorGrantz Šašková, Klára
dc.date.accessioned2023-08-25T10:10:24Z
dc.date.available2023-08-25T10:10:24Z
dc.date.issued2023
dc.identifier.urihttps://hdl.handle.net/20.500.14178/2004
dc.description.abstractDouble-stranded DNA and cyclic dinucleotides activate the cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway, which leads to the production of type I interferons (IFNs) and proinflammatory cytokines by immune cells. These compounds further mediate numerous regulatory immune processes with antiviral or antitumoral properties. Therefore, activators of the cGAS-STING pathway are being investigated for their therapeutic potential.To better understand the immune orchestration induced by STING agonists, we investigated their effect on peripheral blood mononuclear cells (PBMCs), a physiologically relevant complex of immune populations. We demonstrated that STING agonists induce the secretion of a broad portfolio of proinflammatory cytokines. However, treatment with STING agonist is also associated with robust monocyte depletion.en
dc.language.isoen
dc.rightsCreative Commons Uveďte původ 4.0 Internationalcs
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.titleSTING agonists induce monocyte depletion with characteristics of multiple regulated cell deathsen
dcterms.accessRightsopenAccess
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/legalcode
dc.date.updated2023-10-02T06:16:31Z
dc.subject.keywordSTINGen
dc.subject.keywordimmuneen
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MSM//LX22NPO5103
dc.date.embargoStartDate2023-10-02
dc.contributor.organizerWeizmann Institute of Science, spoluorganizátoři - Chemistry and Technology, Prague and Institute of Organic Chemistry a Biochemistry of the Czech Academy of Sciences
dc.type.obd110
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.identifier.obd633975
dc.subject.rivPrimary30000::30100::30102
dcterms.isPartOf.name9th Prague-Weizmann Summer School in Drug Discovery & Development
dcterms.isPartOf.journalYear2023
uk.faculty.primaryId115
uk.faculty.primaryNamePřírodovědecká fakultacs
uk.faculty.primaryNameFaculty of Scienceen
uk.department.primaryId1034
uk.department.primaryNameKatedra genetiky a mikrobiologiecs
uk.department.primaryNameDepartment of Genetics and Microbiologyen
uk.event.name9th Prague-Weizmann Summer School in Drug Discovery & Development
dc.type.obdHierarchyCsABSTRAKT::abstrakt::abstrakt v elektronické podoběcs
dc.type.obdHierarchyEnABSTRACT::abstract::abstract in e-formen
dc.type.obdHierarchyCode110::130::136en
uk.displayTitleSTING agonists induce monocyte depletion with characteristics of multiple regulated cell deathsen


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