dc.contributor.author | Kliegr, Tomáš | |
dc.contributor.author | Jarkovský, Jiří | |
dc.contributor.author | Jiřincová, Helena | |
dc.contributor.author | Kuchař, Jaroslav | |
dc.contributor.author | Karel, Tomáš | |
dc.contributor.author | Chudán, David | |
dc.contributor.author | Vojíř, Stanislav | |
dc.contributor.author | Zavřel, Michal | |
dc.contributor.author | Šanca, Ondřej | |
dc.contributor.author | Tachezy, Ruth | |
dc.date.accessioned | 2023-10-05T11:40:30Z | |
dc.date.available | 2023-10-05T11:40:30Z | |
dc.date.issued | 2023 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14178/2036 | |
dc.description.abstract | Background: The sensitivity and specificity of selected antigen detection rapid diagnostic tests (AG-RDTs) for SARS-CoV-2 were determined in the unvaccinated population when the Delta variant was circulating. Viral loads, dynamics, symptoms and tissue tropism differ between Omicron and Delta.Aim: We aimed to compare AG-RDT sensitivity and specificity in selected subgroups during Omicron vs Delta circulation.Methods: We retrospectively paired AG-RDT results with PCRs registered in Czechia's Information System for Infectious Diseases from 1 to 25 December 2021 (Delta, n = 20,121) and 20 January to 24 February 2022 (Omicron, n = 47,104).Results: When confirmatory PCR was conducted on the same day as AG-RDT as a proxy for antigen testing close to peak viral load, the average sensitivity for Delta was 80.4% and for Omicron 81.4% (p < 0.05). Sensitivity in vaccinated individuals was lower for Omicron (OR = 0.94; 95% confidence interval (CI): 0.87-1.03), particularly in reinfections (OR = 0.83; 95% CI: 0.75-0.92). Saliva AG-RDT sensitivity was below average for both Delta (74.4%) and Omicron (78.4%). Tests on the European Union Category A list had higher sensitivity than tests in Category B. The highest sensitivity for Omicron (88.5%) was recorded for patients with loss of smell or taste, however, these symptoms were almost 10-fold less common than for Delta. The sensitivity of AG-RDTs performed on initially asymptomatic individuals done 1, 2 or 3 days before a positive PCR test was consistently lower for Omicron compared with Delta.Conclusion: Sensitivity for Omicron was lower in subgroups that may become more common if SARS-CoV-2 becomes an endemic virus. | en |
dc.language.iso | en | |
dc.relation.url | https://doi.org/10.2807/1560-7917.ES.2023.28.38.2200938 | |
dc.rights | Creative Commons Uveďte původ 4.0 International | cs |
dc.rights | Creative Commons Attribution 4.0 International | en |
dc.title | Can variants, reinfection, symptoms and test types affect COVID-19 diagnostic performance? A large-scale retrospective study of AG-RDTs during circulation of Delta and Omicron variants, Czechia, December 2021 to February 2022 | en |
dcterms.accessRights | openAccess | |
dcterms.license | https://creativecommons.org/licenses/by/4.0/legalcode | |
dc.date.updated | 2024-05-20T09:40:43Z | |
dc.subject.keyword | AG-RDTs | en |
dc.subject.keyword | SARS-CoV-2 | en |
dc.subject.keyword | Delta | en |
dc.subject.keyword | Omicron | en |
dc.subject.keyword | PCR | en |
dc.identifier.eissn | 1560-7917 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM//LX22NPO5103 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/UK/COOP/COOP | |
dc.date.embargoStartDate | 2024-05-20 | |
dc.type.obd | 73 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | |
dc.identifier.doi | 10.2807/1560-7917.ES.2023.28.38.2200938 | |
dc.identifier.utWos | 001198382000001 | |
dc.identifier.eidScopus | 2-s2.0-85171808891 | |
dc.identifier.obd | 636118 | |
dc.identifier.pubmed | 37733239 | |
dc.subject.rivPrimary | 10000::10600::10607 | |
dc.subject.rivSecondary | 30000::30100::30102 | |
dcterms.isPartOf.name | Eurosurveillance | |
dcterms.isPartOf.issn | 1025-496X | |
dcterms.isPartOf.journalYear | 2023 | |
dcterms.isPartOf.journalVolume | 28 | |
dcterms.isPartOf.journalIssue | 38 | |
uk.faculty.primaryId | 115 | |
uk.faculty.primaryName | Přírodovědecká fakulta | cs |
uk.faculty.primaryName | Faculty of Science | en |
uk.department.primaryId | 1034 | |
uk.department.primaryName | Katedra genetiky a mikrobiologie | cs |
uk.department.primaryName | Department of Genetics and Microbiology | en |
dc.description.pageRange | nestránkováno | |
dc.type.obdHierarchyCs | ČLÁNEK V ČASOPISU::článek v časopisu::původní článek | cs |
dc.type.obdHierarchyEn | JOURNAL ARTICLE::journal article::original article | en |
dc.type.obdHierarchyCode | 73::152::206 | en |
uk.displayTitle | Can variants, reinfection, symptoms and test types affect COVID-19 diagnostic performance? A large-scale retrospective study of AG-RDTs during circulation of Delta and Omicron variants, Czechia, December 2021 to February 2022 | en |