dc.contributor.author | Kaplánek, Robert | |
dc.contributor.author | Kejík, Zdeněk | |
dc.contributor.author | Hajduch, Jan | |
dc.contributor.author | Veselá, Kateřina | |
dc.contributor.author | Kučnirová, Kateřina | |
dc.contributor.author | Skaličková, Markéta | |
dc.contributor.author | Venhauerová, Anna | |
dc.contributor.author | Hosnedlová, Božena | |
dc.contributor.author | Hromádka, Róbert | |
dc.contributor.author | Dytrych, Petr | |
dc.contributor.author | Novotný, Petr | |
dc.contributor.author | Abramenko, Nikita | |
dc.contributor.author | Antonyová, Veronika | |
dc.contributor.author | Hoskovec, David | |
dc.contributor.author | Babula, Petr | |
dc.contributor.author | Masařík, Michal | |
dc.contributor.author | Martásek, Pavel | |
dc.contributor.author | Jakubek, Milan | |
dc.date.accessioned | 2023-10-25T12:10:28Z | |
dc.date.available | 2023-10-25T12:10:28Z | |
dc.date.issued | 2023 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14178/2055 | |
dc.description.abstract | TET proteins (methylcytosine dioxygenases) play an important role in the regulation of gene expression. Dysregulation of their activity is associated with many serious pathogenic states such as oncological diseases. Regulation of their activity by specific inhibitors could represent a promising therapeutic strategy. Therefore, this review describes various types of TET protein inhibitors in terms of their inhibitory mechanism and possible applicability. The potential and possible limitations of this approach are thoroughly discussed in the context of TET protein functionality in living systems. Furthermore, possible therapeutic strategies based on the inhibition of TET proteins are presented and evaluated, especially in the field of oncological diseases. | en |
dc.language.iso | en | |
dc.relation.url | https://doi.org/10.1016/j.biopha.2023.115324 | |
dc.rights | Creative Commons Uveďte původ 4.0 International | cs |
dc.rights | Creative Commons Attribution 4.0 International | en |
dc.title | TET protein inhibitors: Potential and limitations | en |
dcterms.accessRights | openAccess | |
dcterms.license | https://creativecommons.org/licenses/by/4.0/legalcode | |
dc.date.updated | 2025-01-15T10:12:06Z | |
dc.subject.keyword | TET protein | en |
dc.subject.keyword | Inhibitor | en |
dc.subject.keyword | Cancer | en |
dc.subject.keyword | Therapy | en |
dc.subject.keyword | Mitochondria | en |
dc.identifier.eissn | 1950-6007 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM//LX22NPO5102 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM//LX22NPO5107 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/UK/UNCE/MED/UNCE/MED/007 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM/LM/LM2023053 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/UK/COOP/COOP | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/UK/PROGRES/Q26 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/UK/PROGRES/Q27 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/TA0/TN/TN01000013 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/TA0/TN/TN02000109 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/TA0/FW/FW02020128 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MZ0/NU/NU22-D-136 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/FN/I-FN/RVO-VFN64165 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/TA0/TN/TN01000013 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/TA0/TN/TN02000109 | |
dc.date.embargoStartDate | 2025-01-15 | |
dc.type.obd | 73 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | |
dc.identifier.doi | 10.1016/j.biopha.2023.115324 | |
dc.identifier.utWos | 001060916100001 | |
dc.identifier.eidScopus | 2-s2.0-85168132692 | |
dc.identifier.obd | 634324 | |
dc.identifier.riv | RIV/00064165:_____/23:10466664 | |
dc.identifier.riv | RIV/00216208:11110/23:10466664 | |
dc.identifier.pubmed | 37598475 | |
dc.subject.rivPrimary | 30000::30200::30204 | |
dcterms.isPartOf.name | Biomedicine & Pharmacotherapy | |
dcterms.isPartOf.issn | 0753-3322 | |
dcterms.isPartOf.journalYear | 2023 | |
dcterms.isPartOf.journalVolume | 166 | |
dcterms.isPartOf.journalIssue | October | |
uk.faculty.primaryId | 108 | |
uk.faculty.primaryName | 1. lékařská fakulta | cs |
uk.faculty.primaryName | First Faculty of Medicine | en |
uk.faculty.secondaryId | 53 | |
uk.faculty.secondaryName | Všeobecná fakultní nemocnice v Praze | cs |
uk.faculty.secondaryName | Všeobecná fakultní nemocnice v Praze | en |
uk.department.primaryId | 108 | |
uk.department.primaryName | 1. lékařská fakulta | cs |
uk.department.primaryName | First Faculty of Medicine | en |
uk.department.secondaryId | 1522 | |
uk.department.secondaryId | 5000002594 | |
uk.department.secondaryId | 1508 | |
uk.department.secondaryId | 5000002603 | |
uk.department.secondaryId | 100025448551 | |
uk.department.secondaryName | Klinika pediatrie a dědičných poruch metabolismu 1. LF a VFN | cs |
uk.department.secondaryName | Department of Paediatrics and Inherited Metabolic Disorders 1. LF UK a VFN | en |
uk.department.secondaryName | I. chirurgická klinika - břišní, hrudní a úrazová chirurgie 1.LF a VFN | cs |
uk.department.secondaryName | I. chirurgická klinika - břišní, hrudní a úrazová chirurgie 1.LF a VFN | en |
uk.department.secondaryName | I. chirurgická klinika – břišní, hrudní a úrazové chirurgie 1. LF UK a VFN | cs |
uk.department.secondaryName | 1st Department of Surgery – Department of Abdominal, Thoracic Surgery and Traumatology | en |
uk.department.secondaryName | Klinika pediatrie a dědičných poruch metabolismu 1.LF a VFN | cs |
uk.department.secondaryName | Klinika pediatrie a dědičných poruch metabolismu 1.LF a VFN | en |
uk.department.secondaryName | BIOCEV 1. lékařské fakulty | cs |
uk.department.secondaryName | BIOCEV of the 1st Faculty of Medicine | en |
dc.type.obdHierarchyCs | ČLÁNEK V ČASOPISU::článek v časopisu::přehledový článek | cs |
dc.type.obdHierarchyEn | JOURNAL ARTICLE::journal article::summarizing article | en |
dc.type.obdHierarchyCode | 73::152::205 | en |
uk.displayTitle | TET protein inhibitors: Potential and limitations | en |