MiRNA146a is a key component of immunnosupressive environment of hepatocytes chronically infected with HBV and melanoma cells

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Author
Berehovska, Olena
Pimková Polidarová, MarkétaORCiD Profile - 0000-0003-3116-1328WoS Profile - V-2351-2017Scopus Profile - 57212310198
Janovec, VáclavORCiD Profile - 0000-0002-6262-3364WoS Profile - N-7608-2017Scopus Profile - 57193086112
Hirsch, IvanORCiD Profile - 0000-0003-1701-1438WoS Profile - R-3103-2016Scopus Profile - 56275056800
Grantz Šašková, KláraORCiD Profile - 0000-0003-2874-5699WoS Profile - E-1931-2014Scopus Profile - 22954587000
Šímová, Šárka

Publication date
2023
Published in
Czech Chemical Society Symposium Series
Volume / Issue
21 (5)
ISBN / ISSN
ISSN: 2336-7202
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Abstract
Interferon alfa (IFNα) is a pro-inflammatory cytokine with antiviral properties. Our project focuses on Toll-like receptors (TLR)7/9, which upon activation lead to a massive production of INFα.1Therefore, the process needs to be strictly regulated. One of the negative regulators of TLR7/9 signaling is a micro RNA (miRNA) miRNA146a.2
Keywords
miRNA146a.2, immunosuppressive, HBV-producing cells, EVs
Permanent link
https://hdl.handle.net/20.500.14178/2066
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