dc.contributor.author | Šmahel, Michal | |
dc.contributor.author | Nunvář, Jaroslav | |
dc.contributor.editor | Šímová, Šárka | |
dc.date.accessioned | 2023-11-07T11:10:35Z | |
dc.date.available | 2023-11-07T11:10:35Z | |
dc.date.issued | 2023 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14178/2073 | |
dc.description.abstract | High-risk human papillomaviruses can induce malignant transformation of cells resulting in anogenital cancers, particularly cervical cancer (CC), and a proportion of head and neck squamous cell carcinomas (HNSCC). The viral E6 and E7 oncoproteins are required for the induction and maintenance of transformation and the E5 protein contributes to tumorigenesis (1). The E6 and E7 expression is usually increased after the integration ofviral DNAinto the host genome which is associated with inactivation of the viral E2 gene (2). InHNSCC and CC cases driven by HPV infection, analternative tumorigenesis pathway has been described with extrachromosomal persistence of the HPV genome and higher expression of the viral E2, E4,and E5 genes (3). | en |
dc.language.iso | en | |
dc.relation.url | http://www.ccsss.cz/index.php/ccsss/issue/view/41/ | |
dc.rights | Tento výsledek je zpřístupněn v režimu gratis open access, tj. pouze pro čtení. V souladu s § 30 zákona č. 121/2000 Sb., autorského zákona, lze plný text z repozitáře také stáhnout, případně vytisknout, ale pouze pro osobní potřebu. | cs |
dc.rights | The fulltext is published in the repository as read-only, i.e. in gratis open access mode. Repository visitors are entitled to download and print the fulltext published without a licence for their personal use only (in accordance with § 30 of Act No. 121/2000 Coll., the Copyright Act). | en |
dc.title | Can the type of oncogenic transformation by human papillomaviruses influence the choice of cancer immunotherapy? | en |
dcterms.accessRights | openAccess | |
dc.date.updated | 2023-11-07T11:10:35Z | |
dc.subject.keyword | human papillomaviruses | en |
dc.subject.keyword | HPV | en |
dc.subject.keyword | HNSCC | en |
dc.subject.keyword | LILR | en |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM//LX22NPO5103 | |
dc.date.embargoStartDate | 2023-11-07 | |
dc.type.obd | 110 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | |
dc.identifier.obd | 637717 | |
dc.subject.rivPrimary | 30000::30200::30204 | |
dcterms.isPartOf.name | Czech Chemical Society Symposium Series | |
dcterms.isPartOf.issn | 2336-7202 | |
dcterms.isPartOf.journalYear | 2023 | |
dcterms.isPartOf.journalVolume | 21 | |
dcterms.isPartOf.journalIssue | 5 | |
uk.faculty.primaryId | 115 | |
uk.faculty.primaryName | Přírodovědecká fakulta | cs |
uk.faculty.primaryName | Faculty of Science | en |
uk.department.primaryId | 1034 | |
uk.department.primaryName | Katedra genetiky a mikrobiologie | cs |
uk.department.primaryName | Department of Genetics and Microbiology | en |
uk.event.name | The second annual meeting of the National Institute of Virology and Bacteriology (NIVB Meeting 2023| | |
dc.description.pageRange | 222-222 | |
dc.type.obdHierarchyCs | ABSTRAKT::abstrakt::abstrakt v konferenčním sborníku | cs |
dc.type.obdHierarchyEn | ABSTRACT::abstract::abstract in conference proceedings | en |
dc.type.obdHierarchyCode | 110::130::462 | en |
uk.displayTitle | Can the type of oncogenic transformation by human papillomaviruses influence the choice of cancer immunotherapy? | en |