dc.contributor.author | Kůtová, Zuzana | |
dc.contributor.author | Sedláček, Jindřich | |
dc.contributor.author | Adámek, Michael | |
dc.contributor.author | Šubová, Dominika | |
dc.contributor.author | Majer, Pavel | |
dc.contributor.author | Svobodová, Lucie | |
dc.contributor.author | Kadlecová, Alena | |
dc.contributor.author | Machara, Aleš | |
dc.contributor.author | Grantz Šašková, Klára | |
dc.date.accessioned | 2023-12-07T11:10:34Z | |
dc.date.available | 2023-12-07T11:10:34Z | |
dc.date.issued | 2023 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14178/2101 | |
dc.description.abstract | The intracellular accumulation of abnormal proteins exceeding their degradation can cause imbalance in proteostasis resulting in proteotoxic stress that leads to severe pathological stages. This state relates to proteasome saturation/ insufficiency which requires upregulation of proteasome subunits. Nuclear Factor Erythroid 2-related factor 1 (NRF1) is a transcription factor (encoded by NFE2L1) which activates proteasome gene re-synthesis upon impairment of the proteasome function. Therefore, targeted activation of the NRF1 pathway could represent a new approach to delay the onset neurodegenerative diseases and other disorders with disturbed proteostasis. | en |
dc.language.iso | en | |
dc.rights | Creative Commons Uveďte původ 4.0 International | cs |
dc.rights | Creative Commons Attribution 4.0 International | en |
dc.title | Discovery of Small Molecule Activators of NRF1 Transcriptional Activity Preventing Protein Aggregation | en |
dcterms.accessRights | openAccess | |
dcterms.license | https://creativecommons.org/licenses/by/4.0/legalcode | |
dc.date.updated | 2023-12-07T11:10:34Z | |
dc.subject.keyword | proteostasis | en |
dc.subject.keyword | NRF1 | en |
dc.subject.keyword | Protein | en |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM//LX22NPO5103 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/GA0/GA/GA22-16389S | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM//PRIMUS/21/SCI/018 | |
dc.date.embargoStartDate | 2023-12-07 | |
dc.contributor.organizer | Bar IIan University | |
dc.type.obd | 110 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | |
dc.identifier.obd | 639412 | |
dc.subject.rivPrimary | 10000::10600 | |
dcterms.isPartOf.journalYear | 2023 | |
uk.faculty.primaryId | 115 | |
uk.faculty.primaryName | Přírodovědecká fakulta | cs |
uk.faculty.primaryName | Faculty of Science | en |
uk.department.primaryId | 1034 | |
uk.department.primaryName | Katedra genetiky a mikrobiologie | cs |
uk.department.primaryName | Department of Genetics and Microbiology | en |
uk.event.name | EMBO Workshop Proteostasis: From translation to degradation | |
dc.description.pageRange | 124-124 | |
dc.type.obdHierarchyCs | ABSTRAKT::abstrakt::abstrakt v konferenčním sborníku | cs |
dc.type.obdHierarchyEn | ABSTRACT::abstract::abstract in conference proceedings | en |
dc.type.obdHierarchyCode | 110::130::462 | en |
uk.displayTitle | Discovery of Small Molecule Activators of NRF1 Transcriptional Activity Preventing Protein Aggregation | en |