dc.contributor.author | Tesařová, Tereza | |
dc.contributor.author | Koucká, Kamila | |
dc.contributor.author | Václavíková, Radka | |
dc.contributor.author | Šeborová, Karolína | |
dc.contributor.author | Hora, Milan | |
dc.contributor.author | Hes, Ondřej | |
dc.contributor.author | Pivovarčíková, Kristýna | |
dc.contributor.author | Souček, Pavel | |
dc.contributor.author | Fiala, Ondřej | |
dc.date.accessioned | 2023-12-12T10:11:06Z | |
dc.date.available | 2023-12-12T10:11:06Z | |
dc.date.issued | 2023 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14178/2110 | |
dc.description.abstract | Long non-coding RNAs (lncRNAs) serve an important role in cancer progression and may be used as efficient molecular biomarkers. The present study aimed to identify lncRNAs associated with the response to the receptor tyrosine kinase inhibitor sunitinib and transcriptome profile and clinical features of metastatic renal cell carcinoma (mRCC). The gene expression of 84 cancer-associated lncRNAs in tumor and non-malignant tissue samples of 38 patients with mRCC was evaluated using quantitative PCR. In addition, the coding transcriptome was estimated using RNA sequencing in a subgroup of 20 patients and mRNA-lncRNA intersections were identified. In total, 37 and 13 lncRNAs were down- and upregulated, respectively, in tumor compared with non-malignant adjacent tissue samples. A total of 10 and 4 lncRNAs were up- and downregulated, respectively, in good responders to sunitinib compared with poor responders. High expression of HNF1A-AS1 and IPW lncRNAs was associated with prolonged progression-free survival of patients and a high expression of the TUSC7 lncRNA was associated with poor response and worse survival. Significant associations of dysregulated MEG3 and SNHG16 lncRNAs with expression of protein-coding genes representing various pathways, were identified. Furthermore, a significantly higher expression of CLIP4 gene was observed in good responders. The present study revealed promising candidates for predictive and prog-nostic biomarkers with further therapeutic potential. | en |
dc.language.iso | en | |
dc.relation.url | https://doi.org/10.3892/ol.2023.13951 | |
dc.rights | Creative Commons Uveďte původ-Neužívejte dílo komerčně-Nezpracovávejte 4.0 International | cs |
dc.rights | Creative Commons Attribution-NonCommercial-NoDerivativeWorks 4.0 International | en |
dc.title | Association of lncRNA and transcriptome intersections with response to targeted therapy in metastatic renal cell carcinoma | en |
dcterms.accessRights | openAccess | |
dcterms.license | https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode | |
dc.date.updated | 2023-12-12T10:11:06Z | |
dc.subject.keyword | Association | en |
dc.subject.keyword | lncRNA | en |
dc.subject.keyword | transcriptome | en |
dc.subject.keyword | intersections | en |
dc.subject.keyword | with | en |
dc.subject.keyword | response | en |
dc.subject.keyword | targeted | en |
dc.subject.keyword | therapy | en |
dc.subject.keyword | metastatic | en |
dc.subject.keyword | renal | en |
dc.subject.keyword | cell | en |
dc.subject.keyword | carcinoma | en |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM//LX22NPO5102 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/FN/I-FN/I-FNP-10 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/EU/FP8/856620 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/UK/COOP/COOP | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/UK/GAUK/GAUK1074120 | |
dc.date.embargoStartDate | 2023-12-12 | |
dc.type.obd | 73 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | |
dc.identifier.doi | 10.3892/ol.2023.13951 | |
dc.identifier.utWos | 001043647300001 | |
dc.identifier.eidScopus | 2-s2.0-85168144302 | |
dc.identifier.obd | 633832 | |
dc.identifier.pubmed | 37559591 | |
dc.subject.rivPrimary | 30000::30200::30204 | |
dcterms.isPartOf.name | Oncology Letters | |
dcterms.isPartOf.issn | 1792-1074 | |
dcterms.isPartOf.journalYear | 2023 | |
dcterms.isPartOf.journalVolume | 26 | |
dcterms.isPartOf.journalIssue | 3 | |
uk.faculty.primaryId | 111 | |
uk.faculty.primaryName | Lékařská fakulta v Plzni | cs |
uk.faculty.primaryName | Faculty of Medicine in Pilsen | en |
uk.faculty.secondaryId | 54 | |
uk.faculty.secondaryName | Fakultní nemocnice Plzeň | cs |
uk.faculty.secondaryName | University Hospital in Pilsen | en |
uk.department.primaryId | 100012968318 | |
uk.department.primaryName | Biomedicínské centrum | cs |
uk.department.primaryName | Biomedical Center | en |
uk.department.secondaryId | 5000002733 | |
uk.department.secondaryId | 1361 | |
uk.department.secondaryId | 5000002731 | |
uk.department.secondaryId | 5000002725 | |
uk.department.secondaryId | 1425 | |
uk.department.secondaryId | 1439 | |
uk.department.secondaryName | Urologická klinika | cs |
uk.department.secondaryName | Department of Urology | en |
uk.department.secondaryName | Šiklův ústav patologie | cs |
uk.department.secondaryName | Department of Pathology | en |
uk.department.secondaryName | Šiklův patologicko-anatomický ústav | cs |
uk.department.secondaryName | Šiklův patologicko-anatomický ústav | en |
uk.department.secondaryName | Onkologická a radioterapeutická klinika | cs |
uk.department.secondaryName | Department of Oncology and Radiotherapy | en |
uk.department.secondaryName | Onkologická a radioterapeutická klinika | cs |
uk.department.secondaryName | Department of Oncology and Radiotherapeutics | en |
uk.department.secondaryName | Urologická klinika | cs |
uk.department.secondaryName | Department of Urology | en |
dc.description.pageRange | 1-11 | |
dc.type.obdHierarchyCs | ČLÁNEK V ČASOPISU::článek v časopisu::původní článek | cs |
dc.type.obdHierarchyEn | JOURNAL ARTICLE::journal article::original article | en |
dc.type.obdHierarchyCode | 73::152::206 | en |
uk.displayTitle | Association of lncRNA and transcriptome intersections with response to targeted therapy in metastatic renal cell carcinoma | en |