dc.contributor.author | Procházka, Vladimír | |
dc.contributor.author | Lacina, Lukáš | |
dc.contributor.author | Smetana, Karel | |
dc.contributor.author | Svoboda, Martin | |
dc.contributor.author | Skřivanová, Kateřina | |
dc.contributor.author | Beňovská, Miroslava | |
dc.contributor.author | Jarkovský, Jiří | |
dc.contributor.author | Křen, Leoš | |
dc.contributor.author | Kala, Zdeněk | |
dc.date.accessioned | 2023-12-19T09:10:38Z | |
dc.date.available | 2023-12-19T09:10:38Z | |
dc.date.issued | 2023 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14178/2131 | |
dc.description.abstract | Background: The aim of this prospective study was to evaluate the role of serum IL-6 as a potential predictive biomarker of postoperative complications (POC) in elective colorectal surgery. Method: A total of 115 patients underwent colorectal surgery for malignancy. IL-6 was measured on the first and third postoperative days (POD1, POD3), and C-reactive protein (CRP) was measured on the POD3. POC was analysed in subgroups according to Clavien-Dindo (CD), antibiotic (ATB) treatment, intensive care unit (ICU) and hospital length of stay. The predictive power of variables for evaluated endpoints was analysed using receiver-operating characteristic (ROC) analysis and described by area under the curve (AUC). ROC analysis was adopted for the identification of optimal cut-offs. Histological analysis was performed to verify IL-6 production by the tumour. Results: Out of 115 patients who were analysed, 42% had POC. Patients with POC had significantly higher serum levels of IL-6 on POD1 (p < 0.001) and POD3 (p < 0.001). IL-6 early on POD1 as a predictor of antibiotic treatment, ICU stay and hospital stay (AUC 0.818; 0.811; 0.771) did not significantly differ from the AUC of CRP late on POD3 (0.879; 0.838, 0.752). A cut-off IL-6 value of 113 pg/ml on POD1 and 180.5 pg/ml on POD3 in severe complications (CD > 3a) resulted in 75% and 72% sensitivity, 78.6% and 99% specificity, negative predictive value 96.4% and 97% and positive predictive value 29% and 88.9%. Conclusion: The serum level of interleukin-6 can predict severe (CD > 3a) POC early on POD1. On POD3, IL-6 is superior to CRP in terms of high positive predictive power of severe POC. Interestingly, the advantage of IL-6 on POD1 is early prediction of the need for antibiotic treatment, ICU stay and hospital stay, which is comparable to the CRP serum level late on the third POD. | en |
dc.language.iso | en | |
dc.relation.url | https://doi.org/10.1186/s12957-023-03270-9 | |
dc.rights | Creative Commons Uveďte původ 4.0 International | cs |
dc.rights | Creative Commons Attribution 4.0 International | en |
dc.title | Serum concentrations of proinflammatory biomarker interleukin-6 (IL-6) as a predictor of postoperative complications after elective colorectal surgery | en |
dcterms.accessRights | openAccess | |
dcterms.license | https://creativecommons.org/licenses/by/4.0/legalcode | |
dc.date.updated | 2024-01-09T10:10:37Z | |
dc.subject.keyword | Interleukin-6 | en |
dc.subject.keyword | Postoperative complications | en |
dc.subject.keyword | Colorectal surgery | en |
dc.subject.keyword | Infection | en |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM//LX22NPO5102 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/UK/COOP/COOP | |
dc.date.embargoStartDate | 2024-01-09 | |
dc.type.obd | 73 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | |
dc.identifier.doi | 10.1186/s12957-023-03270-9 | |
dc.identifier.utWos | 001126542200003 | |
dc.identifier.eidScopus | 2-s2.0-85179662889 | |
dc.identifier.obd | 639846 | |
dc.identifier.pubmed | 38098074 | |
dc.subject.rivPrimary | 30000::30100::30106 | |
dc.subject.rivSecondary | 30000::30200::30204 | |
dcterms.isPartOf.name | World Journal of Surgical Oncology | |
dcterms.isPartOf.issn | 1477-7819 | |
dcterms.isPartOf.journalYear | 2023 | |
dcterms.isPartOf.journalVolume | 21 | |
dcterms.isPartOf.journalIssue | December | |
uk.faculty.primaryId | 108 | |
uk.faculty.primaryName | 1. lékařská fakulta | cs |
uk.faculty.primaryName | First Faculty of Medicine | en |
uk.department.primaryId | 1488 | |
uk.department.primaryName | Anatomický ústav 1. LF UK | cs |
uk.department.primaryName | Institute of Anatomy | en |
uk.department.secondaryId | 1503 | |
uk.department.secondaryName | Dermatovenerologická klinika 1. LF UK a VFN | cs |
uk.department.secondaryName | Department of Dermatology and Venereology | en |
dc.type.obdHierarchyCs | ČLÁNEK V ČASOPISU::článek v časopisu::původní článek | cs |
dc.type.obdHierarchyEn | JOURNAL ARTICLE::journal article::original article | en |
dc.type.obdHierarchyCode | 73::152::206 | en |
uk.displayTitle | Serum concentrations of proinflammatory biomarker interleukin-6 (IL-6) as a predictor of postoperative complications after elective colorectal surgery | en |