dc.contributor.author | Pavlíková, Nela | |
dc.contributor.author | Šrámek, Jan | |
dc.contributor.author | Jaček, Martin | |
dc.contributor.author | Kovář, Jan | |
dc.contributor.author | Němcová, Vlasta | |
dc.date.accessioned | 2023-12-29T11:10:36Z | |
dc.date.available | 2023-12-29T11:10:36Z | |
dc.date.issued | 2023 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14178/2155 | |
dc.description.abstract | Decades after most countries banned hexachlorocyclohexane, HCH isomers still pollute the environment. Many studies described HCH as a pro-diabetic factor; nevertheless, the effect of HCH isomers on pancreatic beta-cells remains unexplored. This study investigated the effects of a one-month exposure to α-HCH, β-HCH, and γ-HCH on protein expression in human (NES2Y) and rat (INS1E) pancreatic beta-cell lines. α-HCH and γ-HCH increased proinsulin and insulin levels in INS1E cells, while β-HCH showed the opposite trend. α-HCH altered the expression of PKA, ATF3, and PLIN2. β-HCH affected the expression of GLUT1, GLUT2, PKA, ATF3, p-eIF2α, ATP-CL, and PLIN2. γ-HCH altered the expression of PKA, ATF3, PLIN2, PLIN5, and IDH1. From the tested proteins, PKA, ATF3, and PLIN-2 were the most sensitive to HCH exposure and have the potential to be used as biomarkers. | en |
dc.language.iso | en | |
dc.relation.url | https://doi.org/10.1016/j.etap.2023.104299 | |
dc.rights | Creative Commons Uveďte původ 4.0 International | cs |
dc.rights | Creative Commons Attribution 4.0 International | en |
dc.title | Targets for pollutants in rat and human pancreatic beta-cells: The effect of prolonged exposure to sub-lethal concentrations of hexachlorocyclohexane isomers on the expression of function- and survival-related proteins | en |
dcterms.accessRights | openAccess | |
dcterms.license | https://creativecommons.org/licenses/by/4.0/legalcode | |
dc.date.updated | 2024-09-27T13:45:38Z | |
dc.subject.keyword | ATP citrate lyase | en |
dc.subject.keyword | Beta-cells | en |
dc.subject.keyword | Diabetes | en |
dc.subject.keyword | Hexachlorocyclohexane | en |
dc.subject.keyword | Insulin | en |
dc.subject.keyword | Perilipin-2 | en |
dc.identifier.eissn | 1872-7077 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/GA0/GA/GA22-22398S | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM//LX22NPO5104 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/UK/COOP/COOP | |
dc.date.embargoStartDate | 2024-09-27 | |
dc.type.obd | 73 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | |
dc.identifier.doi | 10.1016/j.etap.2023.104299 | |
dc.identifier.utWos | 001098194700001 | |
dc.identifier.eidScopus | 2-s2.0-85174464085 | |
dc.identifier.obd | 637807 | |
dc.identifier.riv | RIV/00216208:11120/23:43926121 | |
dc.identifier.pubmed | 37865351 | |
dc.subject.rivPrimary | 30000::30100 | |
dcterms.isPartOf.name | Environmental Toxicology and Pharmacology | |
dcterms.isPartOf.issn | 1382-6689 | |
dcterms.isPartOf.journalYear | 2023 | |
dcterms.isPartOf.journalVolume | 104 | |
dcterms.isPartOf.journalIssue | November | |
uk.faculty.primaryId | 110 | |
uk.faculty.primaryName | 3. lékařská fakulta | cs |
uk.faculty.primaryName | Third Faculty of Medicine | en |
uk.department.primaryId | 110 | |
uk.department.primaryName | 3. lékařská fakulta | cs |
uk.department.primaryName | Third Faculty of Medicine | en |
uk.department.secondaryId | 100027057758 | |
uk.department.secondaryId | 576 | |
uk.department.secondaryName | Ústav hygieny 3. LF UK | cs |
uk.department.secondaryName | Department of Hygiene 3FM CU | en |
uk.department.secondaryName | Ústav biochemie, buněčné a molekulární biologie 3. LF UK | cs |
uk.department.secondaryName | Department of Biochemistry, Cell and Molecular Biology 3FM CU | en |
dc.type.obdHierarchyCs | ČLÁNEK V ČASOPISU::článek v časopisu::původní článek | cs |
dc.type.obdHierarchyEn | JOURNAL ARTICLE::journal article::original article | en |
dc.type.obdHierarchyCode | 73::152::206 | en |
uk.displayTitle | Targets for pollutants in rat and human pancreatic beta-cells: The effect of prolonged exposure to sub-lethal concentrations of hexachlorocyclohexane isomers on the expression of function- and survival-related proteins | en |