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Genomic characterization of ST38 NDM-5-producing Escherichia coli isolates from an outbreak in the Czech Republic

dc.contributor.authorChudějová, Kateřina
dc.contributor.authorSourenian-Samuelian, Tsolaire
dc.contributor.authorPalkovičová, Jana
dc.contributor.authorStredanska, Katarina
dc.contributor.authorNechutná, Lucie
dc.contributor.authorVlková, Kateřina
dc.contributor.authorHeringová, Vendula
dc.contributor.authorPapagiannitsis, Costas C.
dc.contributor.authorHrabák, Jaroslav
dc.contributor.authorDolejská, Monika
dc.contributor.authorBitar, Ibrahim
dc.date.accessioned2024-05-13T09:10:42Z
dc.date.available2024-05-13T09:10:42Z
dc.date.issued2024
dc.identifier.urihttps://hdl.handle.net/20.500.14178/2435
dc.description.abstractA 2-year national genomic screening in the Czech Republic identified a notable prevalence of the New Delhi metallo-β-lactamase 5 (NDM-5)-producing Escherichia coli sequence type 38 (ST38) in the city of Brno. Forty-two ST38 E. coli isolates harbored the bla(NDM-5) gene on the chromosome. Virulence factors confirmed the persistence of these isolates through biofilm formation. Single Nucleotide Polymorphisms (SNPs)-based phylogeny and CRISPR assay typing showed minimal genomic variations, implying a clonally driven outbreak. Results suggest that this high-risk clone may impose a nationwide problem.en
dc.language.isoen
dc.relation.urlhttps://doi.org/10.1128/aac.00133-24
dc.rightsCreative Commons Uveďte původ 4.0 Internationalcs
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.titleGenomic characterization of ST38 NDM-5-producing Escherichia coli isolates from an outbreak in the Czech Republicen
dcterms.accessRightsopenAccess
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/legalcode
dc.date.updated2024-06-17T07:45:32Z
dc.subject.keywordEscherichia colien
dc.subject.keywordST38en
dc.subject.keywordblaNDM-5en
dc.identifier.eissn1098-6596
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MSM//LX22NPO5103
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MZ0/NU/NU22-09-00645
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MZ0/NU/NU20J-05-00033
dc.date.embargoStartDate2024-06-17
dc.type.obd73
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.identifier.doi10.1128/aac.00133-24
dc.identifier.utWos001203241800001
dc.identifier.eidScopus2-s2.0-85195584470
dc.identifier.obd647101
dc.identifier.pubmed38624228
dc.subject.rivPrimary30000::30300::30303
dcterms.isPartOf.nameAntimicrobial Agents and Chemotherapy
dcterms.isPartOf.issn0066-4804
dcterms.isPartOf.journalYear2024
dcterms.isPartOf.journalVolume68
dcterms.isPartOf.journalIssue6
uk.faculty.primaryId111
uk.faculty.primaryNameLékařská fakulta v Plznics
uk.faculty.primaryNameFaculty of Medicine in Pilsenen
uk.faculty.secondaryId54
uk.faculty.secondaryNameFakultní nemocnice Plzeňcs
uk.faculty.secondaryNameUniversity Hospital in Pilsenen
uk.department.primaryId100012968318
uk.department.primaryNameBiomedicínské centrumcs
uk.department.primaryNameBiomedical Centeren
uk.department.secondaryId5000002737
uk.department.secondaryId1359
uk.department.secondaryNameÚstav mikrobiologiecs
uk.department.secondaryNameÚstav mikrobiologieen
uk.department.secondaryNameÚstav mikrobiologiecs
uk.department.secondaryNameDepartment of Microbiologyen
dc.type.obdHierarchyCsČLÁNEK V ČASOPISU::článek v časopisu::původní článekcs
dc.type.obdHierarchyEnJOURNAL ARTICLE::journal article::original articleen
dc.type.obdHierarchyCode73::152::206en
uk.displayTitleGenomic characterization of ST38 NDM-5-producing Escherichia coli isolates from an outbreak in the Czech Republicen


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