dc.contributor.author | Fiala, Ondřej | |
dc.contributor.author | Hošek, Petr | |
dc.contributor.author | Korunková, Hana | |
dc.contributor.author | Hora, Milan | |
dc.contributor.author | Kolář, Jiří | |
dc.contributor.author | Šorejs, Ondřej | |
dc.contributor.author | Topolčan, Ondřej | |
dc.contributor.author | Filipovský, Jan | |
dc.contributor.author | Liška, Václav | |
dc.contributor.author | Santoni, Matteo | |
dc.contributor.author | Buti, Sebastiano | |
dc.contributor.author | Fínek, Jindřich | |
dc.date.accessioned | 2024-07-08T09:15:52Z | |
dc.date.available | 2024-07-08T09:15:52Z | |
dc.date.issued | 2024 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14178/2548 | |
dc.description.abstract | BACKGROUND: The introduction of novel hormonal therapies represented by enzalutamide (ENZ) and abiraterone acetate (ABI) has reached a great progress in the treatment of metastatic castration-resistant prostate cancer (mCRPC). The majority of mCRPC patients are elderly suffering from chronic co-morbidities requiring use of various concomitant medications. In the present study, we focused on impact of concomitant antihypertensive medication on the outcomes of mCRPC patients treated with ENZ or ABI. METHODS: In total, 300 patients were included and their clinical data were retrospectively analyzed. RESULTS: Angiotensin-converting enzyme inhibitors (ACEIs) represented the only concomitant medication significantly associated with survival. The median radiographic progression-free survival (rPFS) and overall survival (OS) for patients using ACEIs were 15.5 and 32.3 months compared to 10.7 and 24.0 months for those not using ACEIs (p = 0.0053 and p = 0.0238, respectively). Cox multivariable analysis revealed the use of ACEIs a significant predictive factor for both rPFS (HR = 0.704, p = 0.0364) and OS (HR = 0.592, p = 0.0185). CONCLUSION: The findings of this study suggest an association between the concomitant use of ACEIs and longer survival of mCRPC patients receiving ENZ or ABI therapy. | en |
dc.language.iso | en | |
dc.relation.url | https://doi.org/10.1002/cam4.6853 | |
dc.rights | Creative Commons Uveďte původ 4.0 International | cs |
dc.rights | Creative Commons Attribution 4.0 International | en |
dc.title | Concomitant antihypertensive medication and outcome of patients with metastatic castration-resistant prostate cancer receiving enzalutamide or abiraterone acetate | en |
dcterms.accessRights | openAccess | |
dcterms.license | https://creativecommons.org/licenses/by/4.0/legalcode | |
dc.date.updated | 2024-07-08T09:15:52Z | |
dc.subject.keyword | abiraterone acetate | en |
dc.subject.keyword | angiotensin-converting enzyme inhibitors | en |
dc.subject.keyword | antihypertensives | en |
dc.subject.keyword | castration-resistant prostate cancer | en |
dc.subject.keyword | comedication | en |
dc.subject.keyword | enzalutamide | en |
dc.subject.keyword | novel hormonal therapies | en |
dc.identifier.eissn | 2045-7634 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/FN/I-FN/I-FNP-04 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/UK/COOP/COOP | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/EU/FP8/856620 | |
dc.relation.fundingReference | info:eu-repo/grantAgreement/MSM//LX22NPO5102 | |
dc.date.embargoStartDate | 2024-07-08 | |
dc.type.obd | 73 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | |
dc.identifier.doi | 10.1002/cam4.6853 | |
dc.identifier.utWos | 001134266300001 | |
dc.identifier.eidScopus | 2-s2.0-85181215054 | |
dc.identifier.obd | 640536 | |
dc.identifier.pubmed | 38164124 | |
dc.subject.rivPrimary | 30000::30200::30204 | |
dcterms.isPartOf.name | Cancer Medicine | |
dcterms.isPartOf.issn | 2045-7634 | |
dcterms.isPartOf.journalYear | 2024 | |
dcterms.isPartOf.journalVolume | 13 | |
dcterms.isPartOf.journalIssue | 1 | |
uk.faculty.primaryId | 111 | |
uk.faculty.primaryName | Lékařská fakulta v Plzni | cs |
uk.faculty.primaryName | Faculty of Medicine in Pilsen | en |
uk.faculty.secondaryId | 54 | |
uk.faculty.secondaryName | Fakultní nemocnice Plzeň | cs |
uk.faculty.secondaryName | University Hospital in Pilsen | en |
uk.department.primaryId | 100012968318 | |
uk.department.primaryName | Biomedicínské centrum | cs |
uk.department.primaryName | Biomedical Center | en |
uk.department.secondaryId | 5000002733 | |
uk.department.secondaryId | 5000002725 | |
uk.department.secondaryId | 5000002704 | |
uk.department.secondaryId | 1425 | |
uk.department.secondaryId | 1399 | |
uk.department.secondaryId | 1392 | |
uk.department.secondaryId | 5000002701 | |
uk.department.secondaryId | 1381 | |
uk.department.secondaryId | 5000002721 | |
uk.department.secondaryId | 1439 | |
uk.department.secondaryName | Urologická klinika | cs |
uk.department.secondaryName | Department of Urology | en |
uk.department.secondaryName | Onkologická a radioterapeutická klinika | cs |
uk.department.secondaryName | Department of Oncology and Radiotherapy | en |
uk.department.secondaryName | II. Interní klinika | cs |
uk.department.secondaryName | The 2nd Internal Department | en |
uk.department.secondaryName | Onkologická a radioterapeutická klinika | cs |
uk.department.secondaryName | Department of Oncology and Radiotherapeutics | en |
uk.department.secondaryName | Chirurgická klinika | cs |
uk.department.secondaryName | Department of Surgery | en |
uk.department.secondaryName | II.interní klinika | cs |
uk.department.secondaryName | Department of Internal Medicine II | en |
uk.department.secondaryName | Chirurgická klinika | cs |
uk.department.secondaryName | Department of Surgery | en |
uk.department.secondaryName | Centrální laboratoř pro imunoanalýzu | cs |
uk.department.secondaryName | Central Laboratory for Immunoanalysis | en |
uk.department.secondaryName | Oddělení imunochemické diagnostiky | cs |
uk.department.secondaryName | Center for Immunochemistry Diagnostics | en |
uk.department.secondaryName | Urologická klinika | cs |
uk.department.secondaryName | Department of Urology | en |
dc.type.obdHierarchyCs | ČLÁNEK V ČASOPISU::článek v časopisu::původní článek | cs |
dc.type.obdHierarchyEn | JOURNAL ARTICLE::journal article::original article | en |
dc.type.obdHierarchyCode | 73::152::206 | en |
uk.displayTitle | Concomitant antihypertensive medication and outcome of patients with metastatic castration-resistant prostate cancer receiving enzalutamide or abiraterone acetate | en |