Clinical and molecular study of radiation-induced gliomas
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Autor
Jurášek, Bruno
Ondrova, Barbora
Jones, David T W
Sill, Martin
Strnadová, Martina
Datum vydání
2024Publikováno v
Scientific ReportsRočník / Číslo vydání
14 (1)ISBN / ISSN
ISSN: 2045-2322ISBN / ISSN
eISSN: 2045-2322Metadata
Zobrazit celý záznamKolekce
Tato publikace má vydavatelskou verzi s DOI 10.1038/s41598-024-53434-0
Abstrakt
In this study, we provide a comprehensive clinical and molecular biological characterization of radiation-induced gliomas (RIG), including a risk assessment for developing gliomas. A cohort of 12 patients who developed RIG 9.5 years (3-31 years) after previous cranial radiotherapy for brain tumors or T-cell acute lymphoblastic leukemia was established. The derived risk of RIG development based on our consecutive cohort of 371 irradiated patients was 1.6% at 10 years and 3.02% at 15 years. Patients with RIG glioma had a dismal prognosis with a median survival of 7.3 months. We described radiology features that might indicate the suspicion of RIG rather than the primary tumor recurrence. Typical molecular features identified by molecular biology examination included the absence of Histon3 mutation, methylation profile of pedHGG-RTK1 and the presence of recurrent PDGFRA amplification and CDKN2A/B deletion. Of the two long-term surviving patients, one had gliomatosis cerebri, and the other had pleomorphic xanthoastrocytoma with BRAF V600E mutation. In summary, our experience highlights the need for tissue diagnostics to allow detailed molecular biological characterization of the tumor, differentiation of the secondary tumor from the recurrence of the primary disease and potentially finding a therapeutic target.
Klíčová slova
radiation-induced gliomas, ranial radiotherapy, brain tumor, T-cell acute lymphoblastic leukemia
Trvalý odkaz
https://hdl.handle.net/20.500.14178/2581Licence
Licence pro užití plného textu výsledku: Creative Commons Uveďte původ 4.0 International