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The gray area of RQ-PCR-based measurable residual disease: subdividing the "positive, below quantitative range" category

dc.contributor.authorKotrová, Michaela
dc.contributor.authorFroňková, Eva
dc.contributor.authorSvatoň, Michael
dc.contributor.authorDrandi, Daniela
dc.contributor.authorSchön, Felix
dc.contributor.authorHoogeveen, Patricia
dc.contributor.authorHancock, Jeremy
dc.contributor.authorSkotnicová, Aneta
dc.contributor.authorSchilhabel, Anke
dc.contributor.authorEckert, Cornelia
dc.contributor.authorClappier, Emmanuelle
dc.contributor.authorCazzaniga, Gianni
dc.contributor.authorSchäfer, Beat W
dc.contributor.authorvan Dongen, Jacques J M
dc.contributor.authorRitgen, Matthias
dc.contributor.authorPott, Christiane
dc.contributor.authorvan der Velden, Vincent H J
dc.contributor.authorTrka, Jan
dc.contributor.authorBrüggemann, Monika
dc.date.accessioned2024-08-21T15:51:27Z
dc.date.available2024-08-21T15:51:27Z
dc.date.issued2024
dc.identifier.urihttps://hdl.handle.net/20.500.14178/2583
dc.description.abstractDetection of measurable residual disease (MRD) in hematological malignancies is crucial for prognostication and treatment decisions. Real-time quantitative PCR (RQ-PCR), which targets immunoglobulin (IG) and T-cell receptor (TR) rearrangements, is deemed the gold-standard method for MRD detection in national and international clinical trials. However, this approach does have some limitations, primarily related to standard curve performance and non-specific background amplification.en
dc.language.isoen
dc.relation.urlhttps://doi.org/10.1038/s41375-024-02265-z
dc.rightsCreative Commons Uveďte původ 4.0 Internationalcs
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.titleThe gray area of RQ-PCR-based measurable residual disease: subdividing the "positive, below quantitative range" categoryen
dcterms.accessRightsopenAccess
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/legalcode
dc.date.updated2024-08-21T15:51:27Z
dc.subject.keywordmeasurable residual diseaseen
dc.subject.keywordReal-time quantitative PCRen
dc.subject.keywordimmunoglobulinen
dc.subject.keywordT-cell receptoren
dc.identifier.eissn1476-5551
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MZ0/NU/NU20-03-00284
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/UK/GAUK/GAUK318321
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MSM//LX22NPO5102
dc.date.embargoStartDate2024-08-21
dc.type.obd73
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1038/s41375-024-02265-z
dc.identifier.utWos001226866300001
dc.identifier.eidScopus2-s2.0-85193686102
dc.identifier.obd648085
dc.identifier.pubmed38760480
dc.subject.rivPrimary30000::30200::30205
dc.subject.rivSecondary30000::30200::30204
dcterms.isPartOf.nameLeukemia
dcterms.isPartOf.issn0887-6924
dcterms.isPartOf.journalYear2024
dcterms.isPartOf.journalVolume38
dcterms.isPartOf.journalIssue7
uk.faculty.primaryId109
uk.faculty.primaryName2. lékařská fakultacs
uk.faculty.primaryNameSecond Faculty of Medicineen
uk.faculty.secondaryId52
uk.faculty.secondaryNameFakultní nemocnice v Motolecs
uk.faculty.secondaryNameMotol University Hospitalen
uk.department.primaryId109
uk.department.primaryName2. lékařská fakultacs
uk.department.primaryNameSecond Faculty of Medicineen
uk.department.secondaryId1675
uk.department.secondaryId100010692507
uk.department.secondaryNameKlinika dětské hematologie a onkologiecs
uk.department.secondaryNameKlinika dětské hematologie a onkologieen
uk.department.secondaryNameKlinika dětské hematologie a onkologie 2. LF UK a FN Motolcs
uk.department.secondaryNameDepartment of Paediatric Haematology and Oncology, 2nd Faculty of Medicine and Motol University Hosen
dc.description.pageRange1617-1620
dc.type.obdHierarchyCsČLÁNEK V ČASOPISU::článek v časopisu::letter to the editorscs
dc.type.obdHierarchyEnJOURNAL ARTICLE::journal article::letter to the editorsen
dc.type.obdHierarchyCode73::152::233en
uk.displayTitleThe gray area of RQ-PCR-based measurable residual disease: subdividing the "positive, below quantitative range" categoryen


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