miRNA146a is a key component of immunnosupressive environment of hepatocytes chronically infected with HBV

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Author
Berehovska, Olena
Pimková Polidarová, MarkétaORCiD Profile - 0000-0003-3116-1328WoS Profile - V-2351-2017Scopus Profile - 57212310198
Janovec, VáclavORCiD Profile - 0000-0002-6262-3364WoS Profile - N-7608-2017Scopus Profile - 57193086112
Hirsch, IvanORCiD Profile - 0000-0003-1701-1438WoS Profile - R-3103-2016Scopus Profile - 56275056800
Grantz Šašková, KláraORCiD Profile - 0000-0003-2874-5699WoS Profile - E-1931-2014Scopus Profile - 22954587000

Publication date
2024
Published in
Czech Chemical Society Symposium Series
Publisher / Publication place
Česká společnost chemická
Volume / Issue
22 (6)
ISBN / ISSN
ISSN: 2336-7202
ISBN / ISSN
eISSN: 2336-7210
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Abstract
Hepatitis B virus (HBV) causes acute hepatitis and can lead to chronic liver inflammation, often resulting in hepatocellular carcinoma. Known as a stealth virus, virus," HBV can evade recognition by the immune system. Plasmacytoid dendritic cells (pDCs), robust producers of type I and III interferons (IFNs), 1 which are crucial for HBV clearance. However, miRNA146a, an immunosuppressive and proliferative miRNA in hepatocytes, modulates pDCs by silencing TRAF6 and IRAK1/4 proteins.
Keywords
Hepatitis B, virus (HBV), miRNA146a
Permanent link
https://hdl.handle.net/20.500.14178/2658
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