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Rapid method for screening of both calcium and magnesium chelation with comparison of 21 known metal chelators

dc.contributor.authorKonečný, Lukáš
dc.contributor.authorLomozová, Zuzana
dc.contributor.authorKarabanovich, Galina
dc.contributor.authorRoh, Jaroslav
dc.contributor.authorVávrová, Kateřina
dc.contributor.authorMladěnka, Přemysl
dc.date.accessioned2024-11-08T12:11:06Z
dc.date.available2024-11-08T12:11:06Z
dc.date.issued2024
dc.identifier.urihttps://hdl.handle.net/20.500.14178/2686
dc.description.abstractThe aim of this study was to develop an affordable, rapid but sensitive and precise method for determining the degree of chelation of calcium and magnesium ions. Spectrophotometric method using o-cresolphthalein complexone (o-CC) was developed and its biological relevance was confirmed in human platelets by impedance aggregometry. The method was developed and validated. Four and seven out of twenty-one chelators strongly chelated calcium and magnesium ions, respectively. Structure-activity relationships for eight quinolin-8-ols showed improvements in chelation particularly in the cases of dihalogen substitution, and a negative linear relationship between pKa and magnesium chelation was observed. Calcium chelation led to inhibition of platelet aggregation in concentrations corresponding to the complex formation.en
dc.language.isoen
dc.relation.urlhttp://link.springer.com/article/10.1007/s00775-024-02078-6
dc.rightsCreative Commons Uveďte původ 4.0 Internationalcs
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.titleRapid method for screening of both calcium and magnesium chelation with comparison of 21 known metal chelatorsen
dcterms.accessRightsopenAccess
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/legalcode
dc.date.updated2025-03-19T05:11:03Z
dc.subject.keywordChelatoren
dc.subject.keywordDepletionen
dc.subject.keywordSelectivityen
dc.subject.keywordMethodologyen
dc.subject.keywordPlateleten
dc.identifier.eissn1432-1327
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MSM//SVV260663
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MSM//EH22_008/0004607
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/UK/COOP/COOP
dc.date.embargoStartDate2025-03-19
dc.type.obd73
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1007/s00775-024-02078-6
dc.identifier.utWos001335353500002
dc.identifier.eidScopus2-s2.0-85207301546
dc.identifier.obd654801
dc.identifier.pubmed39422739
dc.subject.rivPrimary30000::30100::30104
dc.relation.datasetUrlhttp://zenodo.org/records/13897072
dcterms.isPartOf.nameJournal of Biological Inorganic Chemistry
dcterms.isPartOf.issn0949-8257
dcterms.isPartOf.journalYear2024
dcterms.isPartOf.journalVolume29
dcterms.isPartOf.journalIssue7-8
uk.faculty.primaryId113
uk.faculty.primaryNameFarmaceutická fakulta v Hradci Královécs
uk.faculty.primaryNameFaculty of Pharmacy in Hradec Kraloveen
uk.department.primaryId371
uk.department.primaryNameKatedra farmakologie a toxikologiecs
uk.department.primaryNameDeparment of Pharmacology and Toxicologyen
uk.department.secondaryId366
uk.department.secondaryId100036469221
uk.department.secondaryNameKatedra organické a bioorganické chemiecs
uk.department.secondaryNameDepartment of Organic and Bioorganic Chemistryen
uk.department.secondaryNameKatedra farmakognozie a farmaceutické botanikycs
uk.department.secondaryNameDepartment of Pharmacognosy and Pharmaceutical Botanyen
dc.description.pageRange785-800
dc.type.obdHierarchyCsČLÁNEK V ČASOPISU::článek v časopisu::původní článekcs
dc.type.obdHierarchyEnJOURNAL ARTICLE::journal article::original articleen
dc.type.obdHierarchyCode73::152::206en
uk.displayTitleRapid method for screening of both calcium and magnesium chelation with comparison of 21 known metal chelatorsen


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