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Lipid measures are associated with cognitive functioning in multiple sclerosis patients

dc.contributor.authorLőrincz, Balázs
dc.contributor.authorMotýl, Jiří
dc.contributor.authorFriedová, Lucie
dc.contributor.authorHrych, Daniel
dc.contributor.authorKubala Havrdová, Eva
dc.contributor.authorKrásenský, Jan
dc.contributor.authorUrban, Tadeáš
dc.contributor.authorKober, Tobias
dc.contributor.authorMarechal, Benedicte
dc.contributor.authorVaněčková, Manuela
dc.contributor.authorHoráková, Dana
dc.contributor.authorVrablík, Michal
dc.contributor.authorUher, Tomáš
dc.date.accessioned2024-11-12T11:41:16Z
dc.date.available2024-11-12T11:41:16Z
dc.date.issued2024
dc.identifier.urihttps://hdl.handle.net/20.500.14178/2691
dc.description.abstractBackground: An association between lipid measures and cognitive decline in patients with multiple sclerosis (MS) has been suggested. Objectives: This study aimed to investigate relationships between lipid profile and cognitive performance in a large observational cohort of MS patients. Materials and methods: We included 211 patients with 316 available pairs of lipid and cognitive measures performed over follow-up. The time between lipid and cognitive measures did not exceed 90 days. Baseline data were analyzed by non-parametric Spearman rank correlation test. Repeated measures were analyzed using linear mixed models adjusted for sex, age, education level, disease-modifying therapy status, and depression. Results: Baseline analyses showed a correlation between higher low-density lipoprotein cholesterol (LDL-C) and lower Categorical Verbal Learning Test (CVLT) (rho=-0.15; p = 0.04), lower Symbol Digit Modalities Test (SDMT) (rho=-0.16; p = 0.02) and lower Brief Visuospatial Memory Test-Revised (BVMT-R) scores (rho=-0.12; p = 0.04). Higher high-density lipoprotein cholesterol (HDL-C) was negatively correlated with lower SDMT scores (rho=-0.16; p = 0.02) and lower Paced Auditory Serial Addition Test-3 (PASAT-3) scores (rho=-0.24; p = 0.03). Mixed model analyses of repeated measures showed a negative association between higher LDL-C and lower CVLT (B=-0.02; p < 0.001, Cohen<acute accent>s d = 0.08) and lower BVMT-R (B=-0.01; p = 0.03, Cohen<acute accent>s d=-0.12). Also, the negative association between HDL-C and PASAT-3 was confirmed in the mixed model analysis (B=-0.18; p = 0.01, Cohen<acute accent>s d = 0.07). Additional adjustments of the models for disability assessed by Expanded Disability Status Scale or Normalized Brain Volume did not change the results of the models substantially. Conclusions: Our results suggest a mild negative impact of dyslipidemia on cognitive performance in patients with MS. We propose that dyslipidemia contributes, at least in part, to cognitive decline in MS patients, independent of brain atrophy.en
dc.language.isoen
dc.relation.urlhttps://doi.org/10.1016/j.msard.2024.105879
dc.rightsCreative Commons Uveďte původ 4.0 Internationalcs
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.titleLipid measures are associated with cognitive functioning in multiple sclerosis patientsen
dcterms.accessRightsopenAccess
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/legalcode
dc.date.updated2024-11-12T11:41:16Z
dc.subject.keywordLDLen
dc.subject.keywordHDLen
dc.subject.keywordCognitionen
dc.subject.keywordMultiple sclerosisen
dc.subject.keyworden
dc.identifier.eissn2211-0356
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MSM//LX22NPO5107
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/MZ0/NU/NU22-04-00193
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/FN/I-FN/RVO-VFN64165
dc.relation.fundingReferenceinfo:eu-repo/grantAgreement/UK/COOP/COOP
dc.date.embargoStartDate2024-11-12
dc.type.obd73
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1016/j.msard.2024.105879
dc.identifier.utWos001316726400001
dc.identifier.eidScopus2-s2.0-85203638484
dc.identifier.obd652967
dc.identifier.pubmed39270535
dc.subject.rivPrimary30000::30100::30103
dcterms.isPartOf.nameMultiple Sclerosis and Related Disorders
dcterms.isPartOf.issn2211-0348
dcterms.isPartOf.journalYear2024
dcterms.isPartOf.journalVolume91
dcterms.isPartOf.journalIssueNovember
uk.faculty.primaryId108
uk.faculty.primaryName1. lékařská fakultacs
uk.faculty.primaryNameFirst Faculty of Medicineen
uk.faculty.secondaryId53
uk.faculty.secondaryNameVšeobecná fakultní nemocnice v Prazecs
uk.faculty.secondaryNameVšeobecná fakultní nemocnice v Prazeen
uk.department.primaryId1527
uk.department.primaryNameNeurologická klinika 1. LF UK a VFNcs
uk.department.primaryNameDepartment of Neurologyen
uk.department.secondaryId5000002609
uk.department.secondaryId1519
uk.department.secondaryId1531
uk.department.secondaryId5000002616
uk.department.secondaryId5000002599
uk.department.secondaryNameNeurologická klinika 1.LF a VFNcs
uk.department.secondaryNameNeurologická klinika 1.LF a VFNen
uk.department.secondaryNameIII. interní klinika – klinika endokrinologie a metabolismu 1. LF UK a VFNcs
uk.department.secondaryName3rd Department of Medicine – Department of Endocrinology and Metabolismen
uk.department.secondaryNameRadiodiagnostická klinika 1. LF UK a VFNcs
uk.department.secondaryNameDepartment of Radiologyen
uk.department.secondaryNameRadiodiagnostická klinika 1.LF a VFNcs
uk.department.secondaryNameRadiodiagnostická klinika 1.LF a VFNen
uk.department.secondaryNameIII. interní klinika - klinika endokrinologie a metabolismu 1.LF a VFNcs
uk.department.secondaryNameIII. interní klinika - klinika endokrinologie a metabolismu 1.LF a VFNen
dc.type.obdHierarchyCsČLÁNEK V ČASOPISU::článek v časopisu::původní článekcs
dc.type.obdHierarchyEnJOURNAL ARTICLE::journal article::original articleen
dc.type.obdHierarchyCode73::152::206en
uk.displayTitleLipid measures are associated with cognitive functioning in multiple sclerosis patientsen


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