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Constitutively active Lyn kinase causes a cutaneous small vessel vasculitis and liver fibrosis syndrome
(2023)
Neutrophilic inflammation is a hallmark of many monogenic autoinflammatory diseases; pathomechanisms that regulate extravasation of damaging immune cells into surrounding tissues are poorly understood. Here we identified ...
Restored biosynthetic pathways induced by MSCs serve as rescue mechanism in leukemia cells after L-asparaginase therapy
(2023)
L-asparaginase (ASNase), the drug included on the World Health Organization's List of EssentialMedicines, is irreplaceable in the front-line treatment of childhood acute lymphoblastic leukemia(ALL)1 . However, the relapse ...
Genomic DNA-based measurable residual disease monitoring in pediatric acute myeloid leukemia: unselected consecutive cohort study
(2024)
Measurable residual disease (MRD) monitoring in childhood acute myeloid leukemia (AML) is used to assess response to treatment and for early detection of imminent relapse. In childhood AML, MRD is typically evaluated using ...
Integrated genomic analysis reveals actionable targets in pediatric spinal cord low-grade gliomas
(2022)
Gliomas are the most common central nervous tumors in children and adolescents. However, spinal cord low-grade gliomas (sLGGs) are rare, with scarce information on tumor genomics and epigenomics. To define the molecular ...
Posttreatment positivity of BCR::ABL1 in acute lymphoblastic leukemia: Should we keep track?
(2023)
We read with a great interest the paper focused on different minimal residual disease (MRD) approaches and its significance in Ph+ acute lymphoblastic leukemia (ALL) patients, authored by Short et al. from the MD Anderson ...