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Gut Microbiome Diversity of Porcine Peritonitis Model of Sepsis
(2022)
Animal models are essential in understanding of the mechanisms of sepsis moreover the development and the assessment of emerging therapies. In clinically relevant porcine model, however, a significant ...
Gut microbiome diversity of porcine peritonitis model of sepsis
(2022)
Animal models are essential in understanding of the mechanisms of sepsis moreover the development and the assessment of emerging therapies. In clinically relevant porcine model, however, a significant variability in the ...
Effects of Lactiplantibacillus plantarum and Lacticaseibacillus paracasei supplementation on the faecal metabolome in children with coeliac disease autoimmunity: a randomised, double-blinded placebo-controlled clinical trial
(2023)
INTRODUCTION: Coeliac disease is a lifelong immune-mediated enteropathy manifested as gluten intolerance in individuals carrying specific human leukocyte antigen (HLA) molecules. Other factors than genetics and gluten ...
Emerging Patterns of Microbiome and Resistome in The Healthcare Environment
(2022)
The project led by Prof. Dřevinek at the 2nd Faculty ofMedicine has two main research objectives (see below).Active collaboration with the groups in the consortium isplanned.Research objective 1: Molecular epidemiology ...
Type 1 diabetes incidence increased during the COVID-19 pandemic years 2020-2021 in Czechia: results from a large population-based paediatric register
(2022)
OBJECTIVE: To explore type 1 diabetes incidence patterns during the pandemic years 2020 and 2021 in Czechia, to compare them to the trends from previous decade, and to test its association with indicators of containment ...
Faecal bacteriome and metabolome profiles associated with decreased mucosal inflammatory activity upon anti-TNF therapy in paediatric Crohn's disease
(2024)
BACKGROUND AND AIMS: Treatment by anti-TNFα antibodies (anti-TNF) changes the dysbiotic faecal bacteriome in Crohn's disease (CD). However, it is not known whether these changes are due to decreasing mucosal inflammatory ...
Effects of Lactiplantibacillus plantarum and Lacticaseibacillus paracasei supplementation on the single-cell fecal parasitome in children with celiac disease autoimmunity: a randomized, double-blind placebo-controlled clinical trial
(2023)
BACKGROUND: Lactiplantibacillus plantarum HEAL9 and Lacticaseibacillus paracasei 8700:2 positively affect the fecal bacteriome in children with celiac disease autoimmunity after 6 months of supplementation. The aim of the ...