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Gut Microbiome Diversity of Porcine Peritonitis Model of Sepsis
(2022)
Animal models are essential in understanding of the mechanisms of sepsis moreover the development and the assessment of emerging therapies. In clinically relevant porcine model, however, a significant ...
Gut microbiome diversity of porcine peritonitis model of sepsis
(2022)
Animal models are essential in understanding of the mechanisms of sepsis moreover the development and the assessment of emerging therapies. In clinically relevant porcine model, however, a significant variability in the ...
Polyclonal Spread of Fosfomycin Resistance among Carbapenemase-Producing Members of the Enterobacterales in the Czech Republic
(2023)
Fosfomycin (FOS) has been recently reintroduced into clinical practice, but its effectiveness against multidrug-resistant (MDR) Enterobacterales is reduced due to the emergence of FOS resistance. The copresence of ...
Epidemic spread of KPC-producing bacteria in the Czech Republic
(2022)
Carbapenems are currently last-resort antibiotics for the therapy of infections caused by multidrug-resistant Gram-negative bacteria. Therefore, the resistence to those drugs represents a significant threat of current ...
Preferred β-lactone synthesis can explain high rate of false-negative results in the detection of OXA-48-like carbapenemases
(2022)
The resistance to carbapenems is usually mediated by enzymes hydrolyzing β-lactam ring. Recently, an alternative way of the modification of the antibiotic, a β-lactone formation by OXA-48-like enzymes, in some carbapenems ...
Fosfomycin resistance mechanisms in Enterobacterales: an increasing threat
(2023)
Antimicrobial resistance is well-known to be a global health and development threat. Due to the decrease of effective antimicrobials, re-evaluation in clinical practice of old antibiotics, as fosfomycin (FOS), have been ...
Preferred β-lactone synthesis can explain high rate of false-negative results in the detection of OXA-48-like carbapenemases
(2022)
The resistance to carbapenems is usually mediated by enzymes hydrolyzing β-lactam ring. Recently, an alternative way of the modification of the antibiotic, a β-lactone formation by OXA-48-like enzymes, in some carbapenems ...
Genomic Characterization of Mutli-Drug Resistant Pseudomonas aeruginosa Clinical Isolates: Evaluation and Determination of Ceftolozane/Tazobactam Activity and Resistance Mechanisms
(2022)
Resistance to ceftolozane/tazobactam (C/T) in Pseudomonas aeruginosa is a health concern. In this study, we conducted a whole-genome-based molecular characterization to correlate resistance patterns and β-lactamases with ...
Metodika pro detekci Paenibacillus larvae a Melissococcus plutonius pomocí PCR v reálném čase
Methods for the detection of Paenibacillus larvae and Melissococcus plutonius using real-time PCR
Metodika je určena laboratořím, které se zabývají diagnostikou nákaz včel. Detekce původců moru včelího plodu (Paenibacillus larvae) a hniloby včelího plodu (Melissococcus plutonius) je nezbytná pro prevenci šíření těchto ...
The rapid detection of procalcitonin in septic serum using immunoaffinity MALDI chips
(2023)
Background: Sepsis is a common worldwide health condition with high mortality. It is caused by a dysregulated immune response to the pathogen. Severe infections resulting in sepsis can be also determined by monitoring ...