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Characterization of a human placental clearance system to regulate serotonin levels in the fetoplacental unit

původní článek

open access

vydavatelská verze

Štaud, František

;

Pan, Xin

;

Karahoda, Rona

;

Dong, Xiaojing

;

Kastner, Petr

;

Horáčková, Hana

;

Váchalová, Veronika

;

Markert, Udo R.

;

Abad, Cilia

2023

,

Reproductive Biology and Endocrinology

,

21

(1)

Background Serotonin (5-HT) is a biogenic monoamine with diverse functions in multiple human organs and tissues. During pregnancy, tightly regulated levels of 5-HT in the fetoplacental unit are critical for proper placental ...

Antimycobacterial pyridine carboxamides: From design to in vivo activity

původní článek

embargo

vydavatelská verze

Nawrot, Daria Elżbieta

;

Bouz, Ghada

;

Janďourek, Ondřej

;

Konečná, Klára

;

Paterová, Pavla

;

Bárta, Pavel

;

Novák, Martin

;

Kučera, Radim

;

Zemanová, Júlia

;

Forbak, Martin

;

Korduláková, Jana

;

Pavliš, Oto

;

Kubíčková, Pavla

;

Doležal, Martin

;

Zitko, Jan

2023

,

European Journal of Medicinal Chemistry

,

258

(October)

Tuberculosis is the number one killer of infectious diseases caused by a single microbe, namely Mycobacterium tuberculosis (Mtb). The success rate of curing this infection is decreasing due to emerging antimicrobial ...

Francisella tularensis Glyceraldehyde-3-Phosphate Dehydrogenase Is Relocalized during Intracellular Infection and Reveals Effect on Cytokine Gene Expression and Signaling

původní článek

open access

vydavatelská verze

Pávková, Ivona

;

Kopečková, Monika

;

Link, Marek

;

Vlčák, Erik

;

Filimonenko, Vlada

;

Lecová, Lenka

;

Žáková, Jitka

;

Lásková, Pavlína

;

Sheshko, Valeria

;

Macháček, Miloslav

;

Stulík, Jiří

2023

,

Cells

,

12

(4)

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is known for its multifunctionality in several pathogenic bacteria. Our previously reported data suggest that the GAPDH homologue of Francisella tularensis, GapA, might also ...

Fabrication and characterization of new levan@CBD biocomposite sponges as potential materials in natural, non-toxic wound dressing applications

původní článek

open access

vydavatelská verze

Chełminiak-Dudkiewicz, Dorota

;

Macháček, Miloslav

;

Długaszewska, Jolanta

;

Wujak, Magdalena

;

Smolarkiewicz-Wyczachowski, Aleksander

;

Bocian, Szymon

;

Mylkie, Kinga

;

Gośliński, T.

;

Marszałł, Michał P.

;

Ziegler-Borowska, Marta

2023

,

International Journal of Biological Macromolecules

,

253

(December)

Wound healing is a complex process; therefore, new dressings are frequently required to facilitate it. In this study, porous bacterial levan-based sponges containing cannabis oil (Lev@CBDs) were prepared and fully ...

Insight into the Antibacterial Action of Iodinated Imine, an Analogue of Rafoxanide: a Comprehensive Study of Its Antistaphylococcal Activity

původní článek

open access

postprint

Krátký, Martin

;

Konečná, Klára

;

Janďourek, Ondřej

;

Diepoltová, Adéla

;

Vávrová, Pavlína

;

Voxová, Barbora

;

Vejsová, Marcela

;

Bárta, Pavel

;

Bősze, Szilvia

2023

,

Microbiology spectrum

,

11

(3)

In this study, we have focused on a multiparametric microbiological analysis of the antistaphylococcal action of the iodinated imine BH77, designed as an analogue of rafoxanide. Its antibacterial activity against five ...

Monoterpene indole alkaloids from Vinca minor L. (Apocynaceae): Identification of new structural scaffold for treatment of Alzheimer's disease

původní článek

open access

vydavatelská verze

Vrabec, Rudolf

;

Maříková, Jana

;

Ločárek, Miroslav

;

Korábečný, Jan

;

Hulcová, Daniela

;

Hošťálková, Anna

;

Kuneš, Jiří

;

Chlebek, Jakub

;

Kučera, Tomáš

;

Hrabinová, Martina

;

Jun, Daniel

;

Soukup, Ondřej

;

Andrisano, Vincenza

;

Jenčo, Jaroslav

;

Šafratová, Marcela

;

Nováková, Lucie

;

Opletal, Lubomír

;

Cahlíková, Lucie

2022

,

Phytochemistry

,

194

(February)

One undescribed indole alkaloid together with twenty-two known compounds have been isolated from aerial parts of Vinca minor L. (Apocynaceae). The chemical structures of the isolated alkaloids were determined by a combination ...

Large-Scale Development of Antibacterial Scaffolds: Gentamicin Sulfate-Loaded Biodegradable Nanofibers for Gastrointestinal Applications

původní článek

open access

vydavatelská verze

Klíčová, Markéta

;

Müllerová, Senta

;

Rosendorf, Jáchym

;

Klápšťová, Andrea

;

Jirkovec, Radek

;

Erben, Jakub

;

Petržílková, Michaela

;

Raabová, Hedvika

;

Šatínský, Dalibor

;

Melicheríková, Jana

;

Pálek, Richard

;

Liška, Václav

;

Horáková, Jana

2023

,

ACS Omega

,

8

(43)

The ever-increasing demands of modern medicine drive the development of novel drug delivery materials. In particular, nanofibers are promising for such materials due to their favorable properties. However, most development ...

Developmental expression of catecholamine system in the human placenta and rat fetoplacental unit

původní článek

open access

vydavatelská verze

Karahoda, Rona

;

Váchalová, Veronika

;

Portillo, Ramón

;

Mahrla, Filip

;

Viňas-Noguera, Mireia

;

Abad, Cilia

;

Štaud, František

2024

,

Scientific Reports

,

14

(1)

Catecholamines norepinephrine and dopamine have been implicated in numerous physiological processes within the central nervous system. Emerging evidence has highlighted the importance of tightly regulated monoamine levels ...

Pathological shifts in tryptophan metabolism in human term placenta exposed to LPS or poly I:C

původní článek

open access

vydavatelská verze

Abad, Cilia

;

Karahoda, Rona

;

Orbisová, Anna

;

Kastner, Petr

;

Heblík, Daniel

;

Kučera, Radim

;

Portillo, Ramón

;

Štaud, František

2024

,

Biology of Reproduction

,

110

(4)

Maternal immune activation during pregnancy is a risk factor for offspring neuropsychiatric disorders. Among the mechanistic pathways by which maternal inflammation can affect fetal brain development and programming, those ...

Metabolomic analysis of the human placenta reveals perturbations in amino acids, purine metabolites, and small organic acids in spontaneous preterm birth

původní článek

open access

vydavatelská verze

Cífková, Eva

;

Karahoda, Rona

;

Stráník, Jaroslav

;

Abad, Cilia

;

Kacerovský, Marian

;

Lísa, Miroslav

;

Štaud, František

2024

,

EXCLI Journal

,

23

(February)

Spontaneous preterm delivery presents one of the most complex challenges in obstetrics and is a leading cause of perinatal morbidity and mortality. Although it is a common endpoint for multiple pathological processes, the ...

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